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Recurrent Staphylococcal Infection in Families

Recurrent Staphylococcal Infection in Families Abstract • This controlled double-blind study examined the efficacy of a single large inoculum of Staphylococcus aureus 502A in interrupting intrafamilial spread of recurrent staphylococcal abscesses. Forty families were enrolled in the study and 32 completed six months of follow-up care. All participants were first treated with oral oxacillin sodium or dicloxacillin sodium, twice daily hexachlorophene showers, and bacitracin given nasally for two weeks. Some then received nasal inoculation of 108 to 10 organisms of S aureus 502A while others were given only sterile broth. Fifteen of 17 families or 29 of 36 individuals who received 502A remained free of recurrence for six months of observation, while only four of 15 control families or 18 of 34 members had no recurrences (P < .005). After six months after colonization, 83% of the treatment group retained the 502A organism. (Arch Dermatol 116:189-190, 1980) References 1. Meislin HW, Lerner SA, Graves MH, et al: Cutaneous abscesses: Anaerobic and aerobic bacteriology and out-patient management . Ann Intern Med 87:145-149, 1977.Crossref 2. Shinefield HR, Ribble JC, Boris M, et al: Bacterial interference: Its effect on nursery acquired infection with Staphylococcus aureus: I. Preliminary observations on artificial colonization of newborns . Am J Dis Child 105:646-654, 1963. 3. Boris M, Sellers TF Jr, Eichenwald HF, et al: Bacterial interference: Protection of adults against nasal Staphylococcus aureus infection after colonization with a heterologous S aureus strain . Am J Dis Child 108:252-261, 1964.Crossref 4. Fine RN, Onslow JM, Erwin ML, et al: Bacterial interference in the treatment of recurrent staphylococcal infection in a family . J Pediatr 70:548-553, 1967.Crossref 5. Drutz DJ, Van Way NH, Schaffner W, et al: Bacterial interference in the therapy of recurrent staphylococcal infections: Multiple abscesses due to the implantation of the 502A strain of Staphylococcus . N Engl J Med 275:1161-1165, 1965.Crossref 6. Strauss WG, Maiboch HI, Hurst V: Purposeful change of staphylococcal bacteriophage types: Report of a case in a patient with furunculosis . JAMA 191:759-761, 1965.Crossref 7. Boris M, Shinefield HR, Romano P, et al: Bacterial interference: Protection against recurrent intrafamilial staphylococcal disease . Am J Dis Child 115:521-529, 1968.Crossref 8. Shinefield HR, Ribble JC, Boris M: Bacterial interference between strains of Staphylococcus aureus, 1960-1970 . Am J Dis Child 121:148-152, 1971. 9. Blair ED, Tull AH: Multiple infections among newborns resulting from colonization with Staphylococcus aureus 502A . Am J Clin Pathol 52:42-49, 1969. 10. O'Reilly RJ: Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor . N Engl J Med 297:1311-1318, 1977.Crossref 11. Shinefield HR, Ribble JC, Boris M, et al: Bacterial interference between strains of S aureus . Ann NY Acad Sci 236:444-449, 1974.Crossref 12. Maibach HI, Strauss WG, Shinefield HR: Bacterial interference: Relating to chronic furunculosis in man . Br J Dermatol 81( (suppl 1) ):69-76, 1969.Crossref 13. Tauzon CU, Sheagren JN: Increased rate of carriage of Staphylococcus aureus among narcotic addicts . J Infect Dis 129:725-727, 1974.Crossref 14. Schlesinger D: Microbiology—1975 . Washington, DC, American Society for Microbiology, 1975, pp 110-115. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Recurrent Staphylococcal Infection in Families

Archives of Dermatology , Volume 116 (2) – Feb 1, 1980

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1980.01640260065016
Publisher site
See Article on Publisher Site

Abstract

Abstract • This controlled double-blind study examined the efficacy of a single large inoculum of Staphylococcus aureus 502A in interrupting intrafamilial spread of recurrent staphylococcal abscesses. Forty families were enrolled in the study and 32 completed six months of follow-up care. All participants were first treated with oral oxacillin sodium or dicloxacillin sodium, twice daily hexachlorophene showers, and bacitracin given nasally for two weeks. Some then received nasal inoculation of 108 to 10 organisms of S aureus 502A while others were given only sterile broth. Fifteen of 17 families or 29 of 36 individuals who received 502A remained free of recurrence for six months of observation, while only four of 15 control families or 18 of 34 members had no recurrences (P < .005). After six months after colonization, 83% of the treatment group retained the 502A organism. (Arch Dermatol 116:189-190, 1980) References 1. Meislin HW, Lerner SA, Graves MH, et al: Cutaneous abscesses: Anaerobic and aerobic bacteriology and out-patient management . Ann Intern Med 87:145-149, 1977.Crossref 2. Shinefield HR, Ribble JC, Boris M, et al: Bacterial interference: Its effect on nursery acquired infection with Staphylococcus aureus: I. Preliminary observations on artificial colonization of newborns . Am J Dis Child 105:646-654, 1963. 3. Boris M, Sellers TF Jr, Eichenwald HF, et al: Bacterial interference: Protection of adults against nasal Staphylococcus aureus infection after colonization with a heterologous S aureus strain . Am J Dis Child 108:252-261, 1964.Crossref 4. Fine RN, Onslow JM, Erwin ML, et al: Bacterial interference in the treatment of recurrent staphylococcal infection in a family . J Pediatr 70:548-553, 1967.Crossref 5. Drutz DJ, Van Way NH, Schaffner W, et al: Bacterial interference in the therapy of recurrent staphylococcal infections: Multiple abscesses due to the implantation of the 502A strain of Staphylococcus . N Engl J Med 275:1161-1165, 1965.Crossref 6. Strauss WG, Maiboch HI, Hurst V: Purposeful change of staphylococcal bacteriophage types: Report of a case in a patient with furunculosis . JAMA 191:759-761, 1965.Crossref 7. Boris M, Shinefield HR, Romano P, et al: Bacterial interference: Protection against recurrent intrafamilial staphylococcal disease . Am J Dis Child 115:521-529, 1968.Crossref 8. Shinefield HR, Ribble JC, Boris M: Bacterial interference between strains of Staphylococcus aureus, 1960-1970 . Am J Dis Child 121:148-152, 1971. 9. Blair ED, Tull AH: Multiple infections among newborns resulting from colonization with Staphylococcus aureus 502A . Am J Clin Pathol 52:42-49, 1969. 10. O'Reilly RJ: Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor . N Engl J Med 297:1311-1318, 1977.Crossref 11. Shinefield HR, Ribble JC, Boris M, et al: Bacterial interference between strains of S aureus . Ann NY Acad Sci 236:444-449, 1974.Crossref 12. Maibach HI, Strauss WG, Shinefield HR: Bacterial interference: Relating to chronic furunculosis in man . Br J Dermatol 81( (suppl 1) ):69-76, 1969.Crossref 13. Tauzon CU, Sheagren JN: Increased rate of carriage of Staphylococcus aureus among narcotic addicts . J Infect Dis 129:725-727, 1974.Crossref 14. Schlesinger D: Microbiology—1975 . Washington, DC, American Society for Microbiology, 1975, pp 110-115.

Journal

Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1980

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