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Suppressor Cell Function in Psoriasis

Suppressor Cell Function in Psoriasis Abstract • Recent studies suggest that autoimmunity may play a role in the pathogenesis of psoriasis. In view of these findings, it is postulated that the immunologic defect may be associated with regulation of the immune system. A study was undertaken to determine whether a suppressor cell defect was present. Two groups of patients with active psoriasis who were receiving no therapy were selected. Peripheral blood lymphocytes were pulsed with concanavalin A, 40 μg/cc, for 48 hours. Their ability to suppress a mixed lymphocyte reaction with both autologous and allogeneic responding cells was assessed. There was a significant decrease in suppressor activity in psoriasis patients compared with normal individuals. Although we have not demonstrated that this mechanism is implicated directly in a causal relationship to psoriasis, it nevertheless gives further support to the possible role of the immune system in the pathogenesis of psoriasis. (Arch Dermatol 116:51-55, 1980) References 1. Rook A, Wilkinson DS, Ebling FJG: Textbook of Dermatolog . London, Blackwell Scientific Publishing, 1972. 2. Johnson M-LT: Skin Conditions and the Related Need for Medical Care Among Persons 1-74 Years (Vital Health Statistics: Series II, No. 212). US Department of Health, Education, and Welfare, publication (PHS) 79-1660. 3. Whedon GD: Opening remarks , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, p XXII. 4. Lever WF, Schaumburg-Lever G: Histopathology of the Skin . Toronto, JB Lippincott Co, 1975. 5. Pinkus H, Mehregan AH: A Guide to Dermatohistopathology . New York, Prentice-Hall Inc, 1976. 6. Beutner EH, Chorzelski TP, Jablonska S: Autoimmunity in psoriasis: I. Studies on the possible significance of the universal stratum corneum antibodies in the pathogenesis of psoriasis , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, pp 63-72. 7. Jablonska S, Chorzelski TP, Beutner EH, et al: Autoimmunity in psoriasis: II. Immunohistologic studies on various forms of psoriasis and the Koehner phenomenon , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, pp 73-80. 8. Rimbaud P, Meynadier J, Guilhou JJ, et al: Anti-IgG activity on peripheral blood lymphocytes in psoriasis . Arch Dermatol 108:371-373, 1973.Crossref 9. Krogh HK, Tonder 0: Antibodies in psoriatic scales . Scand J Immunol 2:45-51, 1973.Crossref 10. Guilhou JJ, Clot J, Meynadier J, et al: Immunological aspects of psoriasis: I. Immunoglobulins and anti-IgG factors . Br J Dermatol 94:501-507, 1976.Crossref 11. Florin-Christensen A, Maldonado Cocco JA, Arana R, et al: Antigammaglobulin factors in psoriasis . Dermatologica 149:220-224, 1974.Crossref 12. Cormane RH, Asghar SS: Diagnostic procedures in immunodermatology . J Invest Dermatol 67:129-135, 1976.Crossref 13. Krogh HK: The significance of stratum corneum antibodies: An experimental model in guinea pigs , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, pp 55-62. 14. Guilhou JJ, Meynadier J, Clot J, et al: Immunological aspects of psoriasis: II. Dissociated impairment of thymus-dependent lymphocytes . Br J Dermatol 95:295-301, 1976.Crossref 15. Glinski W, O'Balek S, Langner A, et al: Defective function of T lymphocytes in psoriasis . J Invest Dermatol 70:105-110, 1978.Crossref 16. Gross WL, Packhauser U, Hahn G, et al: Lymphocyte activation by streptococcal antigens in psoriasis . Br J Dermatol 97:529-536, 1977.Crossref 17. Talal N, Steinberg AD: The pathogenesis of autoimmunity in New Zealand black mice . Curr Top Microbiol Immunol 64:79-103, 1974. 18. Krakauer RS, Waldmann TA, Strober W: Loss of suppressor T cells in adult NZB/NZW mice . J Exp Med 144:662-673, 1976.Crossref 19. Shou L, Schwartz SA, Good RA: Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors . J Exp Med 143:1100-1110, 1976.Crossref 20. Waldmann TA, Broder S, Krakauer R, et al: The role of suppressor cells in the pathogenesis of common variable hypogammaglobulinemia and immunodeficiency associated with myeloma . Fed Proc 35:2067-2072, 1976. 21. Waldmann TA, Blaese RM, Broder S, et al: Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity . Ann Intern Med 88:226-238, 1978.Crossref 22. Tagami H, Ofuji S: Leukotactic properties of soluble substances in psoriatic scale . Br J Dermatol 95:1-8, 1976.Crossref 23. Tagami H, Ofuji S: Characterization of leukotactic factor derived from psoriatic scale . Br J Dermatol 97:509-518, 1977.Crossref 24. Krueger GG, Hill HR, Jederberg WW: Inflammatory and immune cell function in psoriasis: A subtle disorder . J Invest Dermatol 71:189-195, 1978.Crossref 25. Horwitz DA: Impaired delayed hypersensitivity in systemic lupus erythematosus . Arthritis Rheum 15:353-359, 1972.Crossref 26. Krakauer KA, Jorrey SB, Zurier RB: Prostaglandin E1 treatment of NZB/w mice . Clin Immunol Immunopathol 11:256-266, 1978.Crossref 27. Aso K: Prostaglandin, cyclic AMP and psoriatic epidermal proliferation , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, pp 109-115. 28. Jacobs KF, Jacobs MM: Prostaglandin treatment of psoriatic skin: Clinical observation . Rocky Mt Med J 71:507, 1974. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Suppressor Cell Function in Psoriasis

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References (29)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1980.01640250053015
Publisher site
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Abstract

Abstract • Recent studies suggest that autoimmunity may play a role in the pathogenesis of psoriasis. In view of these findings, it is postulated that the immunologic defect may be associated with regulation of the immune system. A study was undertaken to determine whether a suppressor cell defect was present. Two groups of patients with active psoriasis who were receiving no therapy were selected. Peripheral blood lymphocytes were pulsed with concanavalin A, 40 μg/cc, for 48 hours. Their ability to suppress a mixed lymphocyte reaction with both autologous and allogeneic responding cells was assessed. There was a significant decrease in suppressor activity in psoriasis patients compared with normal individuals. Although we have not demonstrated that this mechanism is implicated directly in a causal relationship to psoriasis, it nevertheless gives further support to the possible role of the immune system in the pathogenesis of psoriasis. (Arch Dermatol 116:51-55, 1980) References 1. Rook A, Wilkinson DS, Ebling FJG: Textbook of Dermatolog . London, Blackwell Scientific Publishing, 1972. 2. Johnson M-LT: Skin Conditions and the Related Need for Medical Care Among Persons 1-74 Years (Vital Health Statistics: Series II, No. 212). US Department of Health, Education, and Welfare, publication (PHS) 79-1660. 3. Whedon GD: Opening remarks , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, p XXII. 4. Lever WF, Schaumburg-Lever G: Histopathology of the Skin . Toronto, JB Lippincott Co, 1975. 5. Pinkus H, Mehregan AH: A Guide to Dermatohistopathology . New York, Prentice-Hall Inc, 1976. 6. Beutner EH, Chorzelski TP, Jablonska S: Autoimmunity in psoriasis: I. Studies on the possible significance of the universal stratum corneum antibodies in the pathogenesis of psoriasis , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, pp 63-72. 7. Jablonska S, Chorzelski TP, Beutner EH, et al: Autoimmunity in psoriasis: II. Immunohistologic studies on various forms of psoriasis and the Koehner phenomenon , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, pp 73-80. 8. Rimbaud P, Meynadier J, Guilhou JJ, et al: Anti-IgG activity on peripheral blood lymphocytes in psoriasis . Arch Dermatol 108:371-373, 1973.Crossref 9. Krogh HK, Tonder 0: Antibodies in psoriatic scales . Scand J Immunol 2:45-51, 1973.Crossref 10. Guilhou JJ, Clot J, Meynadier J, et al: Immunological aspects of psoriasis: I. Immunoglobulins and anti-IgG factors . Br J Dermatol 94:501-507, 1976.Crossref 11. Florin-Christensen A, Maldonado Cocco JA, Arana R, et al: Antigammaglobulin factors in psoriasis . Dermatologica 149:220-224, 1974.Crossref 12. Cormane RH, Asghar SS: Diagnostic procedures in immunodermatology . J Invest Dermatol 67:129-135, 1976.Crossref 13. Krogh HK: The significance of stratum corneum antibodies: An experimental model in guinea pigs , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, pp 55-62. 14. Guilhou JJ, Meynadier J, Clot J, et al: Immunological aspects of psoriasis: II. Dissociated impairment of thymus-dependent lymphocytes . Br J Dermatol 95:295-301, 1976.Crossref 15. Glinski W, O'Balek S, Langner A, et al: Defective function of T lymphocytes in psoriasis . J Invest Dermatol 70:105-110, 1978.Crossref 16. Gross WL, Packhauser U, Hahn G, et al: Lymphocyte activation by streptococcal antigens in psoriasis . Br J Dermatol 97:529-536, 1977.Crossref 17. Talal N, Steinberg AD: The pathogenesis of autoimmunity in New Zealand black mice . Curr Top Microbiol Immunol 64:79-103, 1974. 18. Krakauer RS, Waldmann TA, Strober W: Loss of suppressor T cells in adult NZB/NZW mice . J Exp Med 144:662-673, 1976.Crossref 19. Shou L, Schwartz SA, Good RA: Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors . J Exp Med 143:1100-1110, 1976.Crossref 20. Waldmann TA, Broder S, Krakauer R, et al: The role of suppressor cells in the pathogenesis of common variable hypogammaglobulinemia and immunodeficiency associated with myeloma . Fed Proc 35:2067-2072, 1976. 21. Waldmann TA, Blaese RM, Broder S, et al: Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity . Ann Intern Med 88:226-238, 1978.Crossref 22. Tagami H, Ofuji S: Leukotactic properties of soluble substances in psoriatic scale . Br J Dermatol 95:1-8, 1976.Crossref 23. Tagami H, Ofuji S: Characterization of leukotactic factor derived from psoriatic scale . Br J Dermatol 97:509-518, 1977.Crossref 24. Krueger GG, Hill HR, Jederberg WW: Inflammatory and immune cell function in psoriasis: A subtle disorder . J Invest Dermatol 71:189-195, 1978.Crossref 25. Horwitz DA: Impaired delayed hypersensitivity in systemic lupus erythematosus . Arthritis Rheum 15:353-359, 1972.Crossref 26. Krakauer KA, Jorrey SB, Zurier RB: Prostaglandin E1 treatment of NZB/w mice . Clin Immunol Immunopathol 11:256-266, 1978.Crossref 27. Aso K: Prostaglandin, cyclic AMP and psoriatic epidermal proliferation , in Farber EM, Cox AJ (eds): Psoriasis Proceedings of the Second International Symposium . New York, Yorke Medical Books, 1976, pp 109-115. 28. Jacobs KF, Jacobs MM: Prostaglandin treatment of psoriatic skin: Clinical observation . Rocky Mt Med J 71:507, 1974.

Journal

Archives of Dermatology – American Medical Association

Published: Jan 1, 1980

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