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Some Gerontologic Considerations in the Practice of Dermatology

Some Gerontologic Considerations in the Practice of Dermatology Abstract Gerontology and geriatrics are areas of increasing importance in medicine today. Although changes in the appearance and behavior of human skin have long been noted to accompany aging, physicians have only recently begun to consider the impact of such an age-associated change on the manifestations of dermatologic disease and on the dermatologic management of elderly patients. Gerontologic studies in such fields as immunology, epidermal cell kinetics, DNA damage and repair, and therapeutics are potentially of great relevance to the practicing dermatologist and deserve increased emphasis within our specialty. (Arch Dermatol 115:1343-1346, 1979) References 1. Our Future Selves: A Research Plan Toward Understanding Aging, publication 77-1096. US Government Printing Office, US Department of Health, Education, and Welfare, Public Health Service, 1977. 2. Basic Facts of Health Industry. US House of Representatives, Committee on Ways and Means, US Government Printing Office, 1971, p 29. 3. Selmanowitz VJ, Rizer RL, Orentreich N: Aging of the skin and its appendages , in Finch CE, Hayflick L (eds): Handbook of the Biology of Aging . New York, Van Nostrand Reinhold Co, 1977, pp 496-509. 4. Boyd E: The weight of the thymus gland in health and disease . Am J Dis Child 43:1162-1211, 1932. 5. Walford RL: Immunologic theory of aging: Current status . Fed Proc 33:2020-2027, 1974. 6. Rowley MJ, Buchanan H, Mackay IR: Reciprocal change with age in antibody to extrinsic and intrinsic antigens . Lancet 2:24-26, 1968.Crossref 7. Hobbs JR: Paraproteinaemia . Proc R Soc Med 62:25-32, 1969. 8. Roberts-Thomson IC, Whittingham S, Youngchaiyud U, et al: Aging, immune response, and mortality . Lancet 2:368-370, 1974.Crossref 9. Reddy MM, Goh K: Band T lymphocytes in man: IV. Circulating G, T, and "null" lymphocytes in aging population . J Gerontol 34:5-8, 1979.Crossref 10. Cztonkowska A, Korlak J: The immune response during aging . J Gerontol 34:9-14, 1979.Crossref 11. Price GB, Makinodan T: Immunologic deficiencies in senescence: I. Characterization of intrinsic deficiencies . J Immunol 108:403-412, 1972. 12. Waldorf DS, Willkens RF, Decker JL: Impaired delayed hypersensitivity in an aging population: Association with antinuclear reactivity and rheumatoid factor . JAMA 203:831-834, 1968.Crossref 13. Tindall JP, Smith JG: Skin lesions of the aged . JAMA 186:1039-1042, 1963.Crossref 14. Mackay IR: Changes in human lymphocyte activity with age . Interdiscipl Topics Geront 11:75-80, 1977. 15. Greenberg LJ, Yunis EJ: Genetic control of autoimmune disease and immune responsiveness and the relationship to aging . Birth Defects 14:249-260, 1978. 16. Hayry Z, Levin S, Sahkenazi A, et al: Selective response of mouse T lymphocytes to different T mitogens in mixed lymphocyte culture induced cytolysis reaction . Cell Immunol 25:121-128, 1976.Crossref 17. Horoszewicz JS, Leong SS, Ito M, et al: Aging in vitro and large-scale interferon production by 15 new strains of human diploid fibroblasts . Infect Immun 19:720-726, 1978. 18. Palmblad J, Haak A: Aging does not change blood granulocyte bactericidal capacity and levels of complement factors 3 and 4 . Gerontology 24:381-385, 1978.Crossref 19. Leyden JJ, McGinley KJ, Grove GL: Age-related differences in the rate of desquamation of skin surface cells , in Adelman RD, Roberts J, Cristofalo VJ (eds): Pharmacological Intervention in the Aging Process . New York, Plenum Press Inc, 1978, pp 297-298. 20. Christophers E, Kligman AM: Percutaneous absorption in aged skin , in Montagna W (ed): Advances in the Biology of Skin . Oxford, England, Pergamon Press, 1965, vol 4, pp 163-175. 21. Carrell A, DuNuoy P: Cicatrization of wounds . J Exp Biol 34:339-348, 1921. 22. Goodson WH III, Hunt TK: Wound healing and aging . J Invest Dermatol 73:88-91, 1979.Crossref 23. Hart RW, Setlow RB: Correlation between deoxyribonucleic acid excision repair and life-span in a number of mammalian species . Proc Natl Acad Sci USA 71:2169-2173, 1974.Crossref 24. Ebbesen P: Aging increases susceptibility of mouse skin to DMBA carcinogenesis independent of general immune status . Science 183:217-218, 1974.Crossref 25. Van Duuren BC, Sivak A, Katz C, et al: The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis on mouse skin . Cancer Res 35:502-505, 1975. 26. Davies RE, Forbes PD, Urbach F: Time distribution of "lifetime dose" of UV: Effect on mouse skin carcinogenesis . Read before the Sixth Annual Meeting of the American Society of Photobiology, Burlington, Vt, June 13, 1978 . 27. Sbano E, Andereassi L, Fimiani M, et al: DNA-repair after UV-irradiation in skin fibroblasts from patients with actinic keratosis . Arch Dermatol Res 262:55-51, 1978.Crossref 28. Lambert B, Ringborg V, Swanbeck G: Ultraviolet-induced DNA repair synthesis in lymphocytes from patients with actinic keratosis . J Invest Dermatol 67:594-598, 1976.Crossref 29. Cleaver JE: Defective repair replication of DNA in xeroderma pigmentosum . Nature 218:542-545, 1968.Crossref 30. Fitzpatrick TB, Szabo G, Mitchell R: Age changes in the human melanocyte system , in Montagna W (ed): Advances in the Biology of Skin . Oxford, England, Pergamon Press, 1964, vol 6, pp 35-50. 31. Quevedo WC Jr, Szabo G, Virks J: Influence of age and UV on the population of dopa-positive melanocytes in human skin . J Invest Dermatol 52:287-290, 1969. 32. Gilchrest BA, Blog FB, Szabo G: Effects of aging and chronic sun exposure on melanocytes in human skin . J Invest Dermatol 73:141-143, 1979.Crossref 33. Pitol HC: Interactions in the natural history of aging and carcinogenesis . Fed Proc 37:2841-2847, 1978. 34. Stern RS, Thibodeau LA, Kleinerman RA, et al: Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis . N Engl J Med 300:809-813, 1979.Crossref 35. Epstein JH: Chemicals and photocarcinogenesis . Australas J Dermatol 18:57-61, 1977.Crossref 36. Steinberg AD, Plots PH, Wolff SM, et al: Cytotoxic drugs in treatment of nonmalignant diseases . Ann Intern Med 76:619-642, 1972.Crossref 37. Gilchrest BA: Relationship between actinic damage and chronologic aging in keratinocyte cultures of human skin . J Invest Dermatol 72:219-223, 1979.Crossref 38. Martin GM, Sprague CA, Epstein CJ: Replicative lifespan of cultivated human cells: Effects of donor's age, tissue, and genotype . Lab Invest 23:86-92, 1970. 39. Schneider EL, Mitsui Y: The relationship between in vitro cellular aging and in vivo human age . Proc Natl Acad Sci USA 73:3584-3588, 1976.Crossref 40. Sanford KK, Parshad R: Intermittent exposure of fluorescent light extends lifespan of human diploid fibroblasts in culture . Nature 268:736-737, 1977.Crossref 41. Smith-Sonneborn J: DNA repair and longevity assurance in Paramecium tetrauselia . Science 203:1115-1117, 1979.Crossref 42. Vestal RE: Drug use in the elderly: A review of problems and special considerations . Drugs 16:358-382, 1978.Crossref 43. Brocklehurst JC, Humphreys GS: The use of indomethacin in old age . Gerontol Clin 7:270-280, 1965.Crossref 44. Seidl LG, Thornton GF, Smith JW, et al: Studies on the epidemiology of adverse drug reactions . Bull Johns Hopkins Hosp 299:315, 1966. 45. Hurwitz N: Predisposing factors in adverse reactions to drugs . Br Med J 1:536-539, 1969.Crossref 46. Caranasos GJ, Stewart RB, Cluff LE: Drug-induced illness leading to hospitalization . JAMA 228:713-717, 1974.Crossref 47. Mendenhall RC, Ramsay DL, Girard RA, et al: A study of the practice of dermatology in the United States: Initial Findings . Arch Dermatol 114:1456-1462, 1978.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Some Gerontologic Considerations in the Practice of Dermatology

Archives of Dermatology , Volume 115 (11) – Nov 1, 1979

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References (44)

Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010110049026
Publisher site
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Abstract

Abstract Gerontology and geriatrics are areas of increasing importance in medicine today. Although changes in the appearance and behavior of human skin have long been noted to accompany aging, physicians have only recently begun to consider the impact of such an age-associated change on the manifestations of dermatologic disease and on the dermatologic management of elderly patients. Gerontologic studies in such fields as immunology, epidermal cell kinetics, DNA damage and repair, and therapeutics are potentially of great relevance to the practicing dermatologist and deserve increased emphasis within our specialty. (Arch Dermatol 115:1343-1346, 1979) References 1. Our Future Selves: A Research Plan Toward Understanding Aging, publication 77-1096. US Government Printing Office, US Department of Health, Education, and Welfare, Public Health Service, 1977. 2. Basic Facts of Health Industry. US House of Representatives, Committee on Ways and Means, US Government Printing Office, 1971, p 29. 3. Selmanowitz VJ, Rizer RL, Orentreich N: Aging of the skin and its appendages , in Finch CE, Hayflick L (eds): Handbook of the Biology of Aging . New York, Van Nostrand Reinhold Co, 1977, pp 496-509. 4. Boyd E: The weight of the thymus gland in health and disease . Am J Dis Child 43:1162-1211, 1932. 5. Walford RL: Immunologic theory of aging: Current status . Fed Proc 33:2020-2027, 1974. 6. Rowley MJ, Buchanan H, Mackay IR: Reciprocal change with age in antibody to extrinsic and intrinsic antigens . Lancet 2:24-26, 1968.Crossref 7. Hobbs JR: Paraproteinaemia . Proc R Soc Med 62:25-32, 1969. 8. Roberts-Thomson IC, Whittingham S, Youngchaiyud U, et al: Aging, immune response, and mortality . Lancet 2:368-370, 1974.Crossref 9. Reddy MM, Goh K: Band T lymphocytes in man: IV. Circulating G, T, and "null" lymphocytes in aging population . J Gerontol 34:5-8, 1979.Crossref 10. Cztonkowska A, Korlak J: The immune response during aging . J Gerontol 34:9-14, 1979.Crossref 11. Price GB, Makinodan T: Immunologic deficiencies in senescence: I. Characterization of intrinsic deficiencies . J Immunol 108:403-412, 1972. 12. Waldorf DS, Willkens RF, Decker JL: Impaired delayed hypersensitivity in an aging population: Association with antinuclear reactivity and rheumatoid factor . JAMA 203:831-834, 1968.Crossref 13. Tindall JP, Smith JG: Skin lesions of the aged . JAMA 186:1039-1042, 1963.Crossref 14. Mackay IR: Changes in human lymphocyte activity with age . Interdiscipl Topics Geront 11:75-80, 1977. 15. Greenberg LJ, Yunis EJ: Genetic control of autoimmune disease and immune responsiveness and the relationship to aging . Birth Defects 14:249-260, 1978. 16. Hayry Z, Levin S, Sahkenazi A, et al: Selective response of mouse T lymphocytes to different T mitogens in mixed lymphocyte culture induced cytolysis reaction . Cell Immunol 25:121-128, 1976.Crossref 17. Horoszewicz JS, Leong SS, Ito M, et al: Aging in vitro and large-scale interferon production by 15 new strains of human diploid fibroblasts . Infect Immun 19:720-726, 1978. 18. Palmblad J, Haak A: Aging does not change blood granulocyte bactericidal capacity and levels of complement factors 3 and 4 . Gerontology 24:381-385, 1978.Crossref 19. Leyden JJ, McGinley KJ, Grove GL: Age-related differences in the rate of desquamation of skin surface cells , in Adelman RD, Roberts J, Cristofalo VJ (eds): Pharmacological Intervention in the Aging Process . New York, Plenum Press Inc, 1978, pp 297-298. 20. Christophers E, Kligman AM: Percutaneous absorption in aged skin , in Montagna W (ed): Advances in the Biology of Skin . Oxford, England, Pergamon Press, 1965, vol 4, pp 163-175. 21. Carrell A, DuNuoy P: Cicatrization of wounds . J Exp Biol 34:339-348, 1921. 22. Goodson WH III, Hunt TK: Wound healing and aging . J Invest Dermatol 73:88-91, 1979.Crossref 23. Hart RW, Setlow RB: Correlation between deoxyribonucleic acid excision repair and life-span in a number of mammalian species . Proc Natl Acad Sci USA 71:2169-2173, 1974.Crossref 24. Ebbesen P: Aging increases susceptibility of mouse skin to DMBA carcinogenesis independent of general immune status . Science 183:217-218, 1974.Crossref 25. Van Duuren BC, Sivak A, Katz C, et al: The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis on mouse skin . Cancer Res 35:502-505, 1975. 26. Davies RE, Forbes PD, Urbach F: Time distribution of "lifetime dose" of UV: Effect on mouse skin carcinogenesis . Read before the Sixth Annual Meeting of the American Society of Photobiology, Burlington, Vt, June 13, 1978 . 27. Sbano E, Andereassi L, Fimiani M, et al: DNA-repair after UV-irradiation in skin fibroblasts from patients with actinic keratosis . Arch Dermatol Res 262:55-51, 1978.Crossref 28. Lambert B, Ringborg V, Swanbeck G: Ultraviolet-induced DNA repair synthesis in lymphocytes from patients with actinic keratosis . J Invest Dermatol 67:594-598, 1976.Crossref 29. Cleaver JE: Defective repair replication of DNA in xeroderma pigmentosum . Nature 218:542-545, 1968.Crossref 30. Fitzpatrick TB, Szabo G, Mitchell R: Age changes in the human melanocyte system , in Montagna W (ed): Advances in the Biology of Skin . Oxford, England, Pergamon Press, 1964, vol 6, pp 35-50. 31. Quevedo WC Jr, Szabo G, Virks J: Influence of age and UV on the population of dopa-positive melanocytes in human skin . J Invest Dermatol 52:287-290, 1969. 32. Gilchrest BA, Blog FB, Szabo G: Effects of aging and chronic sun exposure on melanocytes in human skin . J Invest Dermatol 73:141-143, 1979.Crossref 33. Pitol HC: Interactions in the natural history of aging and carcinogenesis . Fed Proc 37:2841-2847, 1978. 34. Stern RS, Thibodeau LA, Kleinerman RA, et al: Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis . N Engl J Med 300:809-813, 1979.Crossref 35. Epstein JH: Chemicals and photocarcinogenesis . Australas J Dermatol 18:57-61, 1977.Crossref 36. Steinberg AD, Plots PH, Wolff SM, et al: Cytotoxic drugs in treatment of nonmalignant diseases . Ann Intern Med 76:619-642, 1972.Crossref 37. Gilchrest BA: Relationship between actinic damage and chronologic aging in keratinocyte cultures of human skin . J Invest Dermatol 72:219-223, 1979.Crossref 38. Martin GM, Sprague CA, Epstein CJ: Replicative lifespan of cultivated human cells: Effects of donor's age, tissue, and genotype . Lab Invest 23:86-92, 1970. 39. Schneider EL, Mitsui Y: The relationship between in vitro cellular aging and in vivo human age . Proc Natl Acad Sci USA 73:3584-3588, 1976.Crossref 40. Sanford KK, Parshad R: Intermittent exposure of fluorescent light extends lifespan of human diploid fibroblasts in culture . Nature 268:736-737, 1977.Crossref 41. Smith-Sonneborn J: DNA repair and longevity assurance in Paramecium tetrauselia . Science 203:1115-1117, 1979.Crossref 42. Vestal RE: Drug use in the elderly: A review of problems and special considerations . Drugs 16:358-382, 1978.Crossref 43. Brocklehurst JC, Humphreys GS: The use of indomethacin in old age . Gerontol Clin 7:270-280, 1965.Crossref 44. Seidl LG, Thornton GF, Smith JW, et al: Studies on the epidemiology of adverse drug reactions . Bull Johns Hopkins Hosp 299:315, 1966. 45. Hurwitz N: Predisposing factors in adverse reactions to drugs . Br Med J 1:536-539, 1969.Crossref 46. Caranasos GJ, Stewart RB, Cluff LE: Drug-induced illness leading to hospitalization . JAMA 228:713-717, 1974.Crossref 47. Mendenhall RC, Ramsay DL, Girard RA, et al: A study of the practice of dermatology in the United States: Initial Findings . Arch Dermatol 114:1456-1462, 1978.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1979

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