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Angiolymphoid Hyperplasia With Eosinophilia

Angiolymphoid Hyperplasia With Eosinophilia Abstract Angiolymphoid hyperplasia with eosinophilia (AHE) is a distinct clinical and pathologic entity that demonstrates proliferation of endothelial cells associated with varying degrees of lymphocytic, histiocytic, and eosinophilic infiltration. Lymphoid hyperplasia with germinal centers often is present in older lesions and the patients may have an associated blood eosinophilia. Multiple deep nodules developed in a young man on the palmar aspect of the left hand, and subsequently the forehead, histologically diagnostic of AHE. Direct immunofluorescence of the tumor removed from the forehead demonstrated granular deposits of IgA, IgM, and C3 associated with small vessels. Cryoglobulins (IgA, IgM, and IgG) were found in the patient's serum. This new information lends support to the hypothesis that AHE is an inflammatory reactive lesion, possibly secondary to an immunologic injury, rather than a true vascular neoplasm with an associated inflammatory reaction. (Arch Dermatol 115:205-207, 1979) References 1. Kimura T, Yoshimura S, Ishikawa E: Unusual granulation combined with hyperplastic change of lymphatic tissue . Trans Soc Pathol Japan 37:179, 1948. 2. Wells GC, Whimster IW: Subcutaneous angiolymphoid hyperplasia with eosinophilia . Br J Dermatol 81:1-15, 1969.Crossref 3. Wilson-Jones E, Bleehan SS: Inflammatory angiomatous nodules with abnormal blood vessels occurring about the ears and scalp (pseudo or atypical pyogenic granuloma) . Br J Dermatol 81:804-816, 1969.Crossref 4. Kandil E: Dermal angiolymphoid hyperplasia with eosinophilia versus pseudopyogenic granuloma . Br J Dermatol 83:405-408, 1970.Crossref 5. Mehregan AH, Shapiro L: Angiolymphoid hyperplasia with eosinophilia . Arch Dermatol 103:50-57, 1971.Crossref 6. Reed RJ, Terazakis N: Subcutaneous angioblastic lymphoid hyperplasia with eosinophilia (Kimura's disease) . Cancer 29:489-497, 1972.Crossref 7. McIntosh RM, Kaufman DB, Kulvinskas C, et al: Cryoglobulins: I. Studies on the nature, incidence, and clinical significance of serum cryoproteins in glomerulonephritis . J Lab Clin Med 75:566-577, 1970. 8. Zubler RH, Lange G, Lambert PH, et al: Detection of immune complexes in unheated sera by a modified C1q binding test: Effect complexes and application of the test to systemic lupus erythematosus . J Immunol 116:232-235, 1976. 9. Yonemasu K, Stroud R: C1q: Rapid purification method for preparation of monospecific antisera and for biochemical studies . J Immunol 106:304-313, 1971. 10. Gabriel A Jr, Agnello V: Detection of immune complexes: The use of radioimmunoassay with C1q and monoclonal rheumatoid factor . J Clin Invest 59:990-1001, 1977.Crossref 11. Wolff HH, Kinney J, Ackerman AB: Angiolymphoid hyperplasia with follicular mucinosis . Arch Dermatol 114:229-232, 1978.Crossref 12. Castro C, Winkelmann RK: Angiolymphoid hyperplasia with eosinophilia in the skin . Cancer 34:1696-1705, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Angiolymphoid Hyperplasia With Eosinophilia

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010020051016
Publisher site
See Article on Publisher Site

Abstract

Abstract Angiolymphoid hyperplasia with eosinophilia (AHE) is a distinct clinical and pathologic entity that demonstrates proliferation of endothelial cells associated with varying degrees of lymphocytic, histiocytic, and eosinophilic infiltration. Lymphoid hyperplasia with germinal centers often is present in older lesions and the patients may have an associated blood eosinophilia. Multiple deep nodules developed in a young man on the palmar aspect of the left hand, and subsequently the forehead, histologically diagnostic of AHE. Direct immunofluorescence of the tumor removed from the forehead demonstrated granular deposits of IgA, IgM, and C3 associated with small vessels. Cryoglobulins (IgA, IgM, and IgG) were found in the patient's serum. This new information lends support to the hypothesis that AHE is an inflammatory reactive lesion, possibly secondary to an immunologic injury, rather than a true vascular neoplasm with an associated inflammatory reaction. (Arch Dermatol 115:205-207, 1979) References 1. Kimura T, Yoshimura S, Ishikawa E: Unusual granulation combined with hyperplastic change of lymphatic tissue . Trans Soc Pathol Japan 37:179, 1948. 2. Wells GC, Whimster IW: Subcutaneous angiolymphoid hyperplasia with eosinophilia . Br J Dermatol 81:1-15, 1969.Crossref 3. Wilson-Jones E, Bleehan SS: Inflammatory angiomatous nodules with abnormal blood vessels occurring about the ears and scalp (pseudo or atypical pyogenic granuloma) . Br J Dermatol 81:804-816, 1969.Crossref 4. Kandil E: Dermal angiolymphoid hyperplasia with eosinophilia versus pseudopyogenic granuloma . Br J Dermatol 83:405-408, 1970.Crossref 5. Mehregan AH, Shapiro L: Angiolymphoid hyperplasia with eosinophilia . Arch Dermatol 103:50-57, 1971.Crossref 6. Reed RJ, Terazakis N: Subcutaneous angioblastic lymphoid hyperplasia with eosinophilia (Kimura's disease) . Cancer 29:489-497, 1972.Crossref 7. McIntosh RM, Kaufman DB, Kulvinskas C, et al: Cryoglobulins: I. Studies on the nature, incidence, and clinical significance of serum cryoproteins in glomerulonephritis . J Lab Clin Med 75:566-577, 1970. 8. Zubler RH, Lange G, Lambert PH, et al: Detection of immune complexes in unheated sera by a modified C1q binding test: Effect complexes and application of the test to systemic lupus erythematosus . J Immunol 116:232-235, 1976. 9. Yonemasu K, Stroud R: C1q: Rapid purification method for preparation of monospecific antisera and for biochemical studies . J Immunol 106:304-313, 1971. 10. Gabriel A Jr, Agnello V: Detection of immune complexes: The use of radioimmunoassay with C1q and monoclonal rheumatoid factor . J Clin Invest 59:990-1001, 1977.Crossref 11. Wolff HH, Kinney J, Ackerman AB: Angiolymphoid hyperplasia with follicular mucinosis . Arch Dermatol 114:229-232, 1978.Crossref 12. Castro C, Winkelmann RK: Angiolymphoid hyperplasia with eosinophilia in the skin . Cancer 34:1696-1705, 1974.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Feb 1, 1979

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