Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cheilitis Granulomatosa: Successful Treatment With Combined Local Triamcinolone Injections and Surgery

Cheilitis Granulomatosa: Successful Treatment With Combined Local Triamcinolone Injections and... Abstract • Cheilitis granulomatosa is a rare condition that has traditionally proved difficult to treat satisfactorily. Excellent results were obtained in our case with local triamcinolone acetonide injections and surgery. Histopathologic features of the classic, untreated condition were reviewed and compared to the histopathologic features of labial tissues after a series of triamcinolone injections. It was found that the injected medication was effective in achieving some reduction of labial volume, apparently through a necrotizing effect on granulomas with subsequent replacement by fibrous scars. Discontinuation of local injections after initial surgery apparently contributed to an exacerbation, as shown by the histopathology of a second cheiloplastic procedure. We therefore recommend that patients with cheilitis granulomatosa who are receiving combined triamcinolonesurgical therapy continue to receive local triamcinolone injections after surgery in order to minimize the tendency for recurrence. (Arch Dermatol 114:1203-1206, 1978) References 1. Laymon CW: Cheilitis granulomatosa and Melkersson-Rosenthal syndrome . Arch Derm 83:112-118, 1961.Crossref 2. Rintala A, Alhopuro S, Ritsilä V, et al: Cheilitis granulomatosa: The Melkersson-Rosenthal syndrome . Scand J Plast Reconstr Surg 7:130-136, 1973.Crossref 3. Kettel K: Melkersson's syndrome . Arch Otolaryngol 46:341-360, 1947.Crossref 4. New G, Kirsch W: Permanent enlargement of the lips and face secondary to recurring swellings and associated with facial paralysis: A clinical entity . JAMA 100:1230-1232, 1933.Crossref 5. Vistnes L, Kernahan D: The Melkersson-Rosenthal syndrome . Plast Reconstr Surg 48:126-132, 1971.Crossref 6. Eisenbud L, Hymowitz S, Shapiro R: Cheilitis granulomatosa . Oral Surg 32:384-389, 1971.Crossref 7. Miescher G: Über essentielle granulomatose Makrocheilie (Cheilitis granulomatosa) Dermatologica 91:57-85,1945.Crossref 8. Alpert B, Nelson R: Cheilitis granulomatosa: Report of case . J Oral Surg 32:60-61, 1974. 9. Findlay G: Idiopathic enlargements of the lips: Cheilitis granulomatosa, Ascher's syndrome and double lip . Br J Dermatol 66:129-138, 1954.Crossref 10. Carr D: Granulomatous cheilitis in Crohn's disease . Br Med J 4:636, 1974.Crossref 11. Rosenthal C: Klinish-erbbiologischer Beitrag zur Konstitutionspathologie: Gemeinsame Auftreten von Facial islahmung, Angioneurotischem Gesichtodem und Lingua plicata in Arthritismus-Familien . Zentralbl Neurol Psychiatr 131:475-480, 1931.Crossref 12. Ellis JT: Studies on the nature and pathogenesis of muscular degeneration in cortisonetreated rabbits . Bull NY Acad Med 29:814-817, 1953. 13. Kendall PH, Hart MF: Side-effects following triamcinolone . Br Med J 1:682-685, 1959.Crossref 14. Williams RS: Triamcinolone myopathy . Lancet 1:698-701, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cheilitis Granulomatosa: Successful Treatment With Combined Local Triamcinolone Injections and Surgery

Archives of Dermatology , Volume 114 (8) – Aug 1, 1978

Loading next page...
 
/lp/american-medical-association/cheilitis-granulomatosa-successful-treatment-with-combined-local-0jc0mHm6LV

References (18)

Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1978.01640200057015
Publisher site
See Article on Publisher Site

Abstract

Abstract • Cheilitis granulomatosa is a rare condition that has traditionally proved difficult to treat satisfactorily. Excellent results were obtained in our case with local triamcinolone acetonide injections and surgery. Histopathologic features of the classic, untreated condition were reviewed and compared to the histopathologic features of labial tissues after a series of triamcinolone injections. It was found that the injected medication was effective in achieving some reduction of labial volume, apparently through a necrotizing effect on granulomas with subsequent replacement by fibrous scars. Discontinuation of local injections after initial surgery apparently contributed to an exacerbation, as shown by the histopathology of a second cheiloplastic procedure. We therefore recommend that patients with cheilitis granulomatosa who are receiving combined triamcinolonesurgical therapy continue to receive local triamcinolone injections after surgery in order to minimize the tendency for recurrence. (Arch Dermatol 114:1203-1206, 1978) References 1. Laymon CW: Cheilitis granulomatosa and Melkersson-Rosenthal syndrome . Arch Derm 83:112-118, 1961.Crossref 2. Rintala A, Alhopuro S, Ritsilä V, et al: Cheilitis granulomatosa: The Melkersson-Rosenthal syndrome . Scand J Plast Reconstr Surg 7:130-136, 1973.Crossref 3. Kettel K: Melkersson's syndrome . Arch Otolaryngol 46:341-360, 1947.Crossref 4. New G, Kirsch W: Permanent enlargement of the lips and face secondary to recurring swellings and associated with facial paralysis: A clinical entity . JAMA 100:1230-1232, 1933.Crossref 5. Vistnes L, Kernahan D: The Melkersson-Rosenthal syndrome . Plast Reconstr Surg 48:126-132, 1971.Crossref 6. Eisenbud L, Hymowitz S, Shapiro R: Cheilitis granulomatosa . Oral Surg 32:384-389, 1971.Crossref 7. Miescher G: Über essentielle granulomatose Makrocheilie (Cheilitis granulomatosa) Dermatologica 91:57-85,1945.Crossref 8. Alpert B, Nelson R: Cheilitis granulomatosa: Report of case . J Oral Surg 32:60-61, 1974. 9. Findlay G: Idiopathic enlargements of the lips: Cheilitis granulomatosa, Ascher's syndrome and double lip . Br J Dermatol 66:129-138, 1954.Crossref 10. Carr D: Granulomatous cheilitis in Crohn's disease . Br Med J 4:636, 1974.Crossref 11. Rosenthal C: Klinish-erbbiologischer Beitrag zur Konstitutionspathologie: Gemeinsame Auftreten von Facial islahmung, Angioneurotischem Gesichtodem und Lingua plicata in Arthritismus-Familien . Zentralbl Neurol Psychiatr 131:475-480, 1931.Crossref 12. Ellis JT: Studies on the nature and pathogenesis of muscular degeneration in cortisonetreated rabbits . Bull NY Acad Med 29:814-817, 1953. 13. Kendall PH, Hart MF: Side-effects following triamcinolone . Br Med J 1:682-685, 1959.Crossref 14. Williams RS: Triamcinolone myopathy . Lancet 1:698-701, 1959.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1978

There are no references for this article.