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Complement-Fixing Pemphigus Antibodies

Complement-Fixing Pemphigus Antibodies Abstract • The serum of a patient with a typical case of pemphigus vulgaris contained complement-fixing intercellular autoantibodies (pemphigus antibodies). Complement-fixing pemphigus antibodies were demonstrated only during the untreated active stage of the disease and titrated lower than corresponding IgG autoantibodies, which paralleled well with the disease activity. Pemphigus lesional skin, which contained in-vivo-bound IgG, showed the capability of further binding C3 in vitro from normal human serum. It was suggested from these findings that the complement system may play an active role in pemphigus acantholysis through complement-fixing pemphigus antibodies. (Arch Dermatol 114:1191-1192, 1978) References 1. Beutner EH, Chorzelski TP, Jordon, RE: Autosensitization in Pemphigus and Bullous Pemphigoid . Springfield, Ill, Charles C Thomas Publisher, 1970. 2. Nishikawa T, Kurihara S, Harada T, et al: Capability of complement fixation of pemphigus antibodies in vitro . Arch Dermatol Res 260:1-6, 1977.Crossref 3. Nishikawa T, Kurihara S, Harada T, et al: Capability of complement fixation by in vivobound antibodies in pemphigus skin lesions . Clin Exp Dermatol , to be published 4. Jordon RE, Sams Jr WM, Diaz G, et al: Negative complement immunofluorescence in pemphigus . J Invest Dermatol 57:407-410, 1971.Crossref 5. Jordon RE: Complement activation in pemphigus and bullous pemphigoid . J Invest Dermatol 67:366-371, 1976.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Complement-Fixing Pemphigus Antibodies

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1978.01640200045011
Publisher site
See Article on Publisher Site

Abstract

Abstract • The serum of a patient with a typical case of pemphigus vulgaris contained complement-fixing intercellular autoantibodies (pemphigus antibodies). Complement-fixing pemphigus antibodies were demonstrated only during the untreated active stage of the disease and titrated lower than corresponding IgG autoantibodies, which paralleled well with the disease activity. Pemphigus lesional skin, which contained in-vivo-bound IgG, showed the capability of further binding C3 in vitro from normal human serum. It was suggested from these findings that the complement system may play an active role in pemphigus acantholysis through complement-fixing pemphigus antibodies. (Arch Dermatol 114:1191-1192, 1978) References 1. Beutner EH, Chorzelski TP, Jordon, RE: Autosensitization in Pemphigus and Bullous Pemphigoid . Springfield, Ill, Charles C Thomas Publisher, 1970. 2. Nishikawa T, Kurihara S, Harada T, et al: Capability of complement fixation of pemphigus antibodies in vitro . Arch Dermatol Res 260:1-6, 1977.Crossref 3. Nishikawa T, Kurihara S, Harada T, et al: Capability of complement fixation by in vivobound antibodies in pemphigus skin lesions . Clin Exp Dermatol , to be published 4. Jordon RE, Sams Jr WM, Diaz G, et al: Negative complement immunofluorescence in pemphigus . J Invest Dermatol 57:407-410, 1971.Crossref 5. Jordon RE: Complement activation in pemphigus and bullous pemphigoid . J Invest Dermatol 67:366-371, 1976.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Aug 1, 1978

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