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Percutaneous Absorption in Experimental Epidermal Proliferation

Percutaneous Absorption in Experimental Epidermal Proliferation Abstract • Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation. (Arch Dermatol 114:1029-1030, 1978) References 1. Burr GD, Burr MM: A new deficiency disease produced by the rigid exclusion of fat from the diet . J Biol Chem 82:345-367, 1929. 2. Basnayake V, Sinclair HM: The effect of deficiency of essential fatty acids upon the skin , in Popjak G, LeBreton E (eds): Biochemical Problems of Lipids . London, Butterworth & Co, 1956, p 476. 3. VanDorp DA: Essential fatty acids and prostaglandins , in International Congress of Pure and Applied Chemistry . London, Butterworth & Co, 1974, vol 2, pp 117-136. 4. Prottey C, Hartop PJ, Black JG, et al: The repair of impaired epidermal barrier function in rats by the cutaneous application of linoleic acid . Br J Dermatol 94:13-21, 1976.Crossref 5. Lowe NJ, Stoughton RB: Essential fatty acid deficient hairless mouse . Br J Dermatol 96:155-162, 1977.Crossref 6. Lowe NJ: Essential fatty acid deficient hairless mice: The effects of topical agents on the epidermis . Br J Dermatol 97:39-47, 1977.Crossref 7. Stoughton RB: Animal models for in vitro percutaneous absorption , in Maibach HI (ed): Animal Models in Dermatology . Churchill Livingstone, New York, 1975, pp 121-132. 8. Hartop PJ, Prottey C: Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to the skin of essential fatty acid deficient rats . Br J Dermatol 95:255-264, 1976.Crossref 9. DeTomas ME, Brenner RR, Peluffo RO: Position of eicosatrienoic acid in phosphatidylcholine and phosphatidylethanolamine from rats deficient in essential fatty acids . Biochim Biophys Acta 70:472, 1963.Crossref 10. Stoughton RB: Percutaneous absorption: A personal view . J Invest Dermatol 63:305-308, 1974.Crossref 11. Zackheim HS, Feldmann RJ, Lindsay C, et al: Percutaneous absorption of 1,3-bis (2-chloroethyl)-I-nitrosourea (BCNU, carmustine) in mycosis fungoides . Br J Dermatol 97:65-67, 1977.Crossref 12. Grice KA, Bettley FR: Skin water loss and accidental hypothermia in psoriasis, ichthyosis and erythroderma . Br Med J 4:195-198, 1967.Crossref 13. Frost P, Weinstein GD, Bothwell JW, et al: Ichthyosiform dermatoses: III. Studies of transepidermal water loss . Arch Dermatol 98:230-233, 1968.Crossref 14. Cooper MF, McGrath H, Shuster S: Epidermal lipid metabolism in psoriasis and lichen simplex . Br J Dermatol 94:369-378, 1976.Crossref 15. Summerly R, Gray GM, Long VJW, et al: Epidermal lipid synthesis in vitro in psoriasis: Alterations in lipid profile and defects in phospholipid metabolism . Abstracted from Proceedings of the Investigative Group of British Association of Dermatologists, London, January 1977 , pp 10-11. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Percutaneous Absorption in Experimental Epidermal Proliferation

Archives of Dermatology , Volume 114 (7) – Jul 1, 1978

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1978.01640190017005
Publisher site
See Article on Publisher Site

Abstract

Abstract • Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation. (Arch Dermatol 114:1029-1030, 1978) References 1. Burr GD, Burr MM: A new deficiency disease produced by the rigid exclusion of fat from the diet . J Biol Chem 82:345-367, 1929. 2. Basnayake V, Sinclair HM: The effect of deficiency of essential fatty acids upon the skin , in Popjak G, LeBreton E (eds): Biochemical Problems of Lipids . London, Butterworth & Co, 1956, p 476. 3. VanDorp DA: Essential fatty acids and prostaglandins , in International Congress of Pure and Applied Chemistry . London, Butterworth & Co, 1974, vol 2, pp 117-136. 4. Prottey C, Hartop PJ, Black JG, et al: The repair of impaired epidermal barrier function in rats by the cutaneous application of linoleic acid . Br J Dermatol 94:13-21, 1976.Crossref 5. Lowe NJ, Stoughton RB: Essential fatty acid deficient hairless mouse . Br J Dermatol 96:155-162, 1977.Crossref 6. Lowe NJ: Essential fatty acid deficient hairless mice: The effects of topical agents on the epidermis . Br J Dermatol 97:39-47, 1977.Crossref 7. Stoughton RB: Animal models for in vitro percutaneous absorption , in Maibach HI (ed): Animal Models in Dermatology . Churchill Livingstone, New York, 1975, pp 121-132. 8. Hartop PJ, Prottey C: Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to the skin of essential fatty acid deficient rats . Br J Dermatol 95:255-264, 1976.Crossref 9. DeTomas ME, Brenner RR, Peluffo RO: Position of eicosatrienoic acid in phosphatidylcholine and phosphatidylethanolamine from rats deficient in essential fatty acids . Biochim Biophys Acta 70:472, 1963.Crossref 10. Stoughton RB: Percutaneous absorption: A personal view . J Invest Dermatol 63:305-308, 1974.Crossref 11. Zackheim HS, Feldmann RJ, Lindsay C, et al: Percutaneous absorption of 1,3-bis (2-chloroethyl)-I-nitrosourea (BCNU, carmustine) in mycosis fungoides . Br J Dermatol 97:65-67, 1977.Crossref 12. Grice KA, Bettley FR: Skin water loss and accidental hypothermia in psoriasis, ichthyosis and erythroderma . Br Med J 4:195-198, 1967.Crossref 13. Frost P, Weinstein GD, Bothwell JW, et al: Ichthyosiform dermatoses: III. Studies of transepidermal water loss . Arch Dermatol 98:230-233, 1968.Crossref 14. Cooper MF, McGrath H, Shuster S: Epidermal lipid metabolism in psoriasis and lichen simplex . Br J Dermatol 94:369-378, 1976.Crossref 15. Summerly R, Gray GM, Long VJW, et al: Epidermal lipid synthesis in vitro in psoriasis: Alterations in lipid profile and defects in phospholipid metabolism . Abstracted from Proceedings of the Investigative Group of British Association of Dermatologists, London, January 1977 , pp 10-11.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1978

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