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N. Lowe, R. Stoughton (1977)
Essential fatty acid deficient hairless mouse: a model of chronic epidermal hyperproliferationBritish Journal of Dermatology, 96
R. Stoughton (1974)
Percutaneous absorption: a personal view.The Journal of investigative dermatology, 63 4
Sinclair HM Basnayake V (1956)
Biochemical Problems of Lipids
H. Zackheim, R. Feldmann, C. Lindsay, H. Maibach (1977)
Percutaneous absorption of I,3‐bis (2‐chloroethyl)‐I‐nitrosourea (BCNU, carmustine) in mycosis fungoidesBritish Journal of Dermatology, 97
Stoughton RB Lowe NJ (1977)
Essential fatty acid deficient hairless mouseBr J Dermatol, 96
M. Cooper, H. Mcgrath, S. Shuster (1976)
Epidermal lipid metabolism in psoriasis and lichen simplexBritish Journal of Dermatology, 94
VanDorp DA (1974)
International Congress of Pure and Applied Chemistry, 2
P. Frost, G. Weinstein, J. Bothwell, R. Wildnauer (1968)
Ichthyosiform dermatoses. 3. Studies of transepidermal water loss.Archives of dermatology, 98 3
N. Lowe (1977)
Essential fatty acid deficient hairless mouse: the effects of topical agents on the epidermisBritish Journal of Dermatology, 97
G. Burr, M. Burr (1929)
Nutrition classics from The Journal of Biological Chemistry 82:345-67, 1929. A new deficiency disease produced by the rigid exclusion of fat from the diet.Nutrition reviews, 31 8
P. Hartop, C. Prottey (1976)
Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to the skin of essential fatty acid‐deficient ratsBritish Journal of Dermatology, 95
Burr MM Burr GD (1929)
A new deficiency disease produced by the rigid exclusion of fat from the dietJ Biol Chem, 82
K. Grice, F. Bettley (1967)
Skin water loss and accidental hypothermia in psoriasis, ichthyosis, and erythroderma.British Medical Journal, 4
Stoughton RB (1975)
Animal Models in Dermatology
Gray GM Summerly R
Proceedings of the Investigative Group of British Association of Dermatologists, London, January 1977
C. Prottey, P. Hartop, J. Black, J. Mccormack (1976)
The repair of impaired epidermal barrier function in rats by the cutaneous application of linoleic acidBritish Journal of Dermatology, 94
M. Detomas, R. Brenner, R. Peluffo (1963)
POSITION OF EICOSATRIENOIC ACID IN THE PHOSPHATIDYLCHOLINE AND PHOSPHATIDYLETHANOLAMINE FROM RATS DEFICIENT IN ESSENTIAL FATTY ACIDS.Biochimica et biophysica acta, 70
Abstract • Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation. (Arch Dermatol 114:1029-1030, 1978) References 1. Burr GD, Burr MM: A new deficiency disease produced by the rigid exclusion of fat from the diet . J Biol Chem 82:345-367, 1929. 2. Basnayake V, Sinclair HM: The effect of deficiency of essential fatty acids upon the skin , in Popjak G, LeBreton E (eds): Biochemical Problems of Lipids . London, Butterworth & Co, 1956, p 476. 3. VanDorp DA: Essential fatty acids and prostaglandins , in International Congress of Pure and Applied Chemistry . London, Butterworth & Co, 1974, vol 2, pp 117-136. 4. Prottey C, Hartop PJ, Black JG, et al: The repair of impaired epidermal barrier function in rats by the cutaneous application of linoleic acid . Br J Dermatol 94:13-21, 1976.Crossref 5. Lowe NJ, Stoughton RB: Essential fatty acid deficient hairless mouse . Br J Dermatol 96:155-162, 1977.Crossref 6. Lowe NJ: Essential fatty acid deficient hairless mice: The effects of topical agents on the epidermis . Br J Dermatol 97:39-47, 1977.Crossref 7. Stoughton RB: Animal models for in vitro percutaneous absorption , in Maibach HI (ed): Animal Models in Dermatology . Churchill Livingstone, New York, 1975, pp 121-132. 8. Hartop PJ, Prottey C: Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to the skin of essential fatty acid deficient rats . Br J Dermatol 95:255-264, 1976.Crossref 9. DeTomas ME, Brenner RR, Peluffo RO: Position of eicosatrienoic acid in phosphatidylcholine and phosphatidylethanolamine from rats deficient in essential fatty acids . Biochim Biophys Acta 70:472, 1963.Crossref 10. Stoughton RB: Percutaneous absorption: A personal view . J Invest Dermatol 63:305-308, 1974.Crossref 11. Zackheim HS, Feldmann RJ, Lindsay C, et al: Percutaneous absorption of 1,3-bis (2-chloroethyl)-I-nitrosourea (BCNU, carmustine) in mycosis fungoides . Br J Dermatol 97:65-67, 1977.Crossref 12. Grice KA, Bettley FR: Skin water loss and accidental hypothermia in psoriasis, ichthyosis and erythroderma . Br Med J 4:195-198, 1967.Crossref 13. Frost P, Weinstein GD, Bothwell JW, et al: Ichthyosiform dermatoses: III. Studies of transepidermal water loss . Arch Dermatol 98:230-233, 1968.Crossref 14. Cooper MF, McGrath H, Shuster S: Epidermal lipid metabolism in psoriasis and lichen simplex . Br J Dermatol 94:369-378, 1976.Crossref 15. Summerly R, Gray GM, Long VJW, et al: Epidermal lipid synthesis in vitro in psoriasis: Alterations in lipid profile and defects in phospholipid metabolism . Abstracted from Proceedings of the Investigative Group of British Association of Dermatologists, London, January 1977 , pp 10-11.
Archives of Dermatology – American Medical Association
Published: Jul 1, 1978
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