Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Betamethasone and Its Derivatives

Betamethasone and Its Derivatives Abstract To the Editor.— May I draw your attention to a confusing nomenclature in the article entitled "Multicenter Trial Analysis: Fluocinonide and Betamethasone Gel in Psoriasis" (Arch Dermatol 112:1729-1733, 1976). The corticosteroid under study was betamethasone benzoate, and it is correctly referred to just once in the summary, once in the text, and in the figures. However, in the title and on most of the occasions in the text, it is referred to as betamethasone. Betamethasone benzoate, like betamethasone valerate, is an ester derived from betamethasone (alcohol), and all three substances have different biological properties. Betamethasone is a highly active anti-inflammatory corticosteroid when given systemically, but has little activity when applied to the skin. On the other hand, the two esters have a relatively low level of systemic activity but are highly active when applied topically. Further, considerable differences in activity can be seen between various esters derived from the same References 1. Phillipps GH: Locally active corticosteroids: Structure activity relationships , in Wilson LC, Marks R (eds): Mechanisms of Topical Corticosteroid Activity . Edinburgh, Churchill Livingstone, 1976, pp 1-18. 2. Champion RH, Goldin D: Clinical aspects of topical therapy . Pharm J 218:328-330, 1975. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Betamethasone and Its Derivatives

Archives of Dermatology , Volume 113 (7) – Jul 1, 1977

Betamethasone and Its Derivatives

Abstract

Abstract To the Editor.— May I draw your attention to a confusing nomenclature in the article entitled "Multicenter Trial Analysis: Fluocinonide and Betamethasone Gel in Psoriasis" (Arch Dermatol 112:1729-1733, 1976). The corticosteroid under study was betamethasone benzoate, and it is correctly referred to just once in the summary, once in the text, and in the figures. However, in the title and on most of the occasions in the text, it is referred to as betamethasone....
Loading next page...
 
/lp/american-medical-association/betamethasone-and-its-derivatives-7WBtEsDis9

References (2)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1977.01640070122039
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— May I draw your attention to a confusing nomenclature in the article entitled "Multicenter Trial Analysis: Fluocinonide and Betamethasone Gel in Psoriasis" (Arch Dermatol 112:1729-1733, 1976). The corticosteroid under study was betamethasone benzoate, and it is correctly referred to just once in the summary, once in the text, and in the figures. However, in the title and on most of the occasions in the text, it is referred to as betamethasone. Betamethasone benzoate, like betamethasone valerate, is an ester derived from betamethasone (alcohol), and all three substances have different biological properties. Betamethasone is a highly active anti-inflammatory corticosteroid when given systemically, but has little activity when applied to the skin. On the other hand, the two esters have a relatively low level of systemic activity but are highly active when applied topically. Further, considerable differences in activity can be seen between various esters derived from the same References 1. Phillipps GH: Locally active corticosteroids: Structure activity relationships , in Wilson LC, Marks R (eds): Mechanisms of Topical Corticosteroid Activity . Edinburgh, Churchill Livingstone, 1976, pp 1-18. 2. Champion RH, Goldin D: Clinical aspects of topical therapy . Pharm J 218:328-330, 1975.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1977

There are no references for this article.