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Topical Methoxsalen and Blacklight in the Treatment of Psoriasis

Topical Methoxsalen and Blacklight in the Treatment of Psoriasis Abstract • Thirty patients with recalcitrant psoriasis were treated with topical methoxsalen and blacklight (UVA). A 1% concentration either in an acetone, alcohol, propylene glycol vehicle, or hydrophilic ointment, USP, applied two hours before light exposure was highly effective. Twelve patients were completely cleared and nine were markedly improved in three to five weeks. Plaque-type and guttate psoriasis responded best while exfoliative psoriasis benefitted less. Maintenance of a phototoxic reaction in the lesion was necessary for total resolution. Topical methoxsalen and blacklight is feasible for outpatient treatment of plaque-type psoriasis of limited extent. (Arch Dermatol 113:292-296, 1977) References 1. Alderson JE: Heliotherapy in psoriasis . Arch Dermatol Syphilol 8:79-80, 1923.Crossref 2. Goeckerman WH: The treatment of psoriasis . Northwest Med 24:229-231, 1925. 3. Goeckerman WH: Treatment of psoriasis . Arch Dermatol Syphilol 24:446-450, 1923.Crossref 4. Perry HO, Soderstrom CW, Schulze RW: The Goeckerman treatment of psoriasis . Arch Dermatol 98:178-182, 1968.Crossref 5. Everett MA, Miller JV: Coal tar and ultraviolet light: II. Cummulative effects . Arch Dermatol 84:937-940, 1961.Crossref 6. Epstein JH, Fukuyama K: Effects of 8-methoxypsoralen (8-MOP) induced phototoxic effects on mammalian epidermal macromolecular synthesis in vivo . Photochem Photobiol 21:325-330, 1975.Crossref 7. Baden HP, Parrington JM, Delhandty JDA, et al: DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light . Biochem Biophys Acta 261:247-248, 1972. 8. Walter JE, Voorhees JJ, Kelsey WH, et al: Psoralen plus blacklight inhibits epidermal DNA synthesis . Arch Dermatol 107:861-865, 1973.Crossref 9. Allyn B: Studies on phototoxicity in man and laboratory animals . Read before the 21st. annual meeting of the American Academy of Dermatology, Chicago, December 1962 . 10. Willis I, Harris DR: Resistant psoriasis: Combined methoxsalen-anthralin therapy . Arch Dermatol 107:358-362, 1973.Crossref 11. Walter JF, Voorhees JJ: Psoriasis improved by psoralens plus blacklight . Acta Derm Venereol (Stockh) 53:469-472, 1973. 12. Kligman A, Goldstein FP: Oral dosage in methoxsalen phototoxicity . Arch Dermatol 107:548-550, 1973.Crossref 13. Pathak MA, Fellman JH, Kaufman KD: The effect of structural alterations on the erythemal activity of furocoumarins: Psoralens . J Invest Dermatol 35:165-183, 1960.Crossref 14. Weber G: Combined 8-methoxypsoralen and blacklight therapy of psoriasis . Br J Dermatol 90:317-323, 1974.Crossref 15. Tronnier H, Schule D: Zur dermatologischen therapie von dermatosen mit langwelligem UV nach photosensibilisierung der huat mit Methoxsalen erste ergebnisse bei der psoriasis vulgaris . Z Haut Geschlechtskr 48:385-393, 1973. 16. Parrish JH, Fitzpatrick T, Tanenbaum L, et al: Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light . N Engl J Med 291:3-7, 1974.Crossref 17. Urbach F: Modification of ultraviolet carcinogenesis by photoactive agents . J Invest Dermatol 32:373-378, 1959.Crossref 18. Forbes PD, Urbach F: Experimental modification of photocarcinogenesis: III. Simulation of exposures to sunlight and fluorescent whitening agents . Food Cosmet Toxicol 13:343-345, 1975.Crossref 19. Fischer T, Juhlin L: Photochemotherapy of psoriasis with trioxsalen baths and dysprosium lamps . Arch Dermatol , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Topical Methoxsalen and Blacklight in the Treatment of Psoriasis

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1977.01640030038004
Publisher site
See Article on Publisher Site

Abstract

Abstract • Thirty patients with recalcitrant psoriasis were treated with topical methoxsalen and blacklight (UVA). A 1% concentration either in an acetone, alcohol, propylene glycol vehicle, or hydrophilic ointment, USP, applied two hours before light exposure was highly effective. Twelve patients were completely cleared and nine were markedly improved in three to five weeks. Plaque-type and guttate psoriasis responded best while exfoliative psoriasis benefitted less. Maintenance of a phototoxic reaction in the lesion was necessary for total resolution. Topical methoxsalen and blacklight is feasible for outpatient treatment of plaque-type psoriasis of limited extent. (Arch Dermatol 113:292-296, 1977) References 1. Alderson JE: Heliotherapy in psoriasis . Arch Dermatol Syphilol 8:79-80, 1923.Crossref 2. Goeckerman WH: The treatment of psoriasis . Northwest Med 24:229-231, 1925. 3. Goeckerman WH: Treatment of psoriasis . Arch Dermatol Syphilol 24:446-450, 1923.Crossref 4. Perry HO, Soderstrom CW, Schulze RW: The Goeckerman treatment of psoriasis . Arch Dermatol 98:178-182, 1968.Crossref 5. Everett MA, Miller JV: Coal tar and ultraviolet light: II. Cummulative effects . Arch Dermatol 84:937-940, 1961.Crossref 6. Epstein JH, Fukuyama K: Effects of 8-methoxypsoralen (8-MOP) induced phototoxic effects on mammalian epidermal macromolecular synthesis in vivo . Photochem Photobiol 21:325-330, 1975.Crossref 7. Baden HP, Parrington JM, Delhandty JDA, et al: DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light . Biochem Biophys Acta 261:247-248, 1972. 8. Walter JE, Voorhees JJ, Kelsey WH, et al: Psoralen plus blacklight inhibits epidermal DNA synthesis . Arch Dermatol 107:861-865, 1973.Crossref 9. Allyn B: Studies on phototoxicity in man and laboratory animals . Read before the 21st. annual meeting of the American Academy of Dermatology, Chicago, December 1962 . 10. Willis I, Harris DR: Resistant psoriasis: Combined methoxsalen-anthralin therapy . Arch Dermatol 107:358-362, 1973.Crossref 11. Walter JF, Voorhees JJ: Psoriasis improved by psoralens plus blacklight . Acta Derm Venereol (Stockh) 53:469-472, 1973. 12. Kligman A, Goldstein FP: Oral dosage in methoxsalen phototoxicity . Arch Dermatol 107:548-550, 1973.Crossref 13. Pathak MA, Fellman JH, Kaufman KD: The effect of structural alterations on the erythemal activity of furocoumarins: Psoralens . J Invest Dermatol 35:165-183, 1960.Crossref 14. Weber G: Combined 8-methoxypsoralen and blacklight therapy of psoriasis . Br J Dermatol 90:317-323, 1974.Crossref 15. Tronnier H, Schule D: Zur dermatologischen therapie von dermatosen mit langwelligem UV nach photosensibilisierung der huat mit Methoxsalen erste ergebnisse bei der psoriasis vulgaris . Z Haut Geschlechtskr 48:385-393, 1973. 16. Parrish JH, Fitzpatrick T, Tanenbaum L, et al: Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light . N Engl J Med 291:3-7, 1974.Crossref 17. Urbach F: Modification of ultraviolet carcinogenesis by photoactive agents . J Invest Dermatol 32:373-378, 1959.Crossref 18. Forbes PD, Urbach F: Experimental modification of photocarcinogenesis: III. Simulation of exposures to sunlight and fluorescent whitening agents . Food Cosmet Toxicol 13:343-345, 1975.Crossref 19. Fischer T, Juhlin L: Photochemotherapy of psoriasis with trioxsalen baths and dysprosium lamps . Arch Dermatol , to be published.

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1977

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