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Herpes Gestationis: A Clinicopathologic Study

Herpes Gestationis: A Clinicopathologic Study Abstract • Herpes gestationis is a pruritic, blistering eruption of pregnancy and the puerperium. In three patients with immunologically verified disease, the clinical presentation consisted of widespread erythematous, edematous papules and plaques, grouped vesicles on erythematous bases, and tense bullae. Histologically, these lesions showed a moderately dense, mixed-inflammatory cell infiltrate around superficial and deep dermal blood vessels, and focal necrosis of epidermal basal cells. Papillary dermal edema, subepidermal bullae, and spongiosis were prominent. Eosinophils were frequently present in the subepidermal and intraepidermal vesicles. Differentiation of herpes gestationis from other blistering diseases and other dermatitides of pregnancy may be difficult. (Arch Dermatol 112:1543-1548, 1976) References 1. Kolodney RC: Herpes gestationis . Am J Obstet Gynecol 104:39-45, 1969. 2. Katz SI: Dermatoses and Pregnancy . New York, Medcom Inc, 1972. 3. Provost TT, Tomasi TB Jr: Evidence for complement activation via the alternate pathway in skin diseases . J Clin Invest 52:1779-1787, 1973.Crossref 4. Bushkell LL, Jordan RE, Goltz RW: Herpes gestationis . Arch Dermatol 110:65-69, 1974.Crossref 5. Katz SI, Hertz KC, Yaoita H: Herpes gestationis: Immunopathology and characterization of the HG factor . J Clin Invest 57:1434-1441, 1976.Crossref 6. Jablonska S, Chorzelski TP, Beutner EH, et al: Immunologic phenomena in herpes gestationis . Arch Dermatol Forsch 252:267-274, 1975.Crossref 7. Kocsis M, Eeg TL, Husby G, et al: Immunofluorescence studies in herpes gestationis . Arch Derm Vernereol 55:25-29, 1975. 8. Ackerman AB, Penneys NS, Clark WH: Erythema multiforme exudativum: Distinctive pathologic process . Br J Dermatol 84:554-566, 1971.Crossref 9. Yaoita H, Gullino M, Katz SI: Herpes gestationis: Ultrastructure and ultrastructural localization of in vivo-bound complement . J Invest Dermatol 66:383-388, 1976.Crossref 10. Schatz M, Patterson R, Zeitz S, et al: Corticosteroid therapy for the pregnant asthmatic patient . JAMA 233:804-807, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Herpes Gestationis: A Clinicopathologic Study

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630350019005
Publisher site
See Article on Publisher Site

Abstract

Abstract • Herpes gestationis is a pruritic, blistering eruption of pregnancy and the puerperium. In three patients with immunologically verified disease, the clinical presentation consisted of widespread erythematous, edematous papules and plaques, grouped vesicles on erythematous bases, and tense bullae. Histologically, these lesions showed a moderately dense, mixed-inflammatory cell infiltrate around superficial and deep dermal blood vessels, and focal necrosis of epidermal basal cells. Papillary dermal edema, subepidermal bullae, and spongiosis were prominent. Eosinophils were frequently present in the subepidermal and intraepidermal vesicles. Differentiation of herpes gestationis from other blistering diseases and other dermatitides of pregnancy may be difficult. (Arch Dermatol 112:1543-1548, 1976) References 1. Kolodney RC: Herpes gestationis . Am J Obstet Gynecol 104:39-45, 1969. 2. Katz SI: Dermatoses and Pregnancy . New York, Medcom Inc, 1972. 3. Provost TT, Tomasi TB Jr: Evidence for complement activation via the alternate pathway in skin diseases . J Clin Invest 52:1779-1787, 1973.Crossref 4. Bushkell LL, Jordan RE, Goltz RW: Herpes gestationis . Arch Dermatol 110:65-69, 1974.Crossref 5. Katz SI, Hertz KC, Yaoita H: Herpes gestationis: Immunopathology and characterization of the HG factor . J Clin Invest 57:1434-1441, 1976.Crossref 6. Jablonska S, Chorzelski TP, Beutner EH, et al: Immunologic phenomena in herpes gestationis . Arch Dermatol Forsch 252:267-274, 1975.Crossref 7. Kocsis M, Eeg TL, Husby G, et al: Immunofluorescence studies in herpes gestationis . Arch Derm Vernereol 55:25-29, 1975. 8. Ackerman AB, Penneys NS, Clark WH: Erythema multiforme exudativum: Distinctive pathologic process . Br J Dermatol 84:554-566, 1971.Crossref 9. Yaoita H, Gullino M, Katz SI: Herpes gestationis: Ultrastructure and ultrastructural localization of in vivo-bound complement . J Invest Dermatol 66:383-388, 1976.Crossref 10. Schatz M, Patterson R, Zeitz S, et al: Corticosteroid therapy for the pregnant asthmatic patient . JAMA 233:804-807, 1975.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Nov 1, 1976

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