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Cutaneous Phycomycosis (Mucormycosis) With Fatal Pulmonary Dissemination

Cutaneous Phycomycosis (Mucormycosis) With Fatal Pulmonary Dissemination Abstract • Phycomycosis of the skin manifested as a spontaneous solitary ulcer of the leg in a patient with uremia. The infection later spread to the lungs and produced fatal pulmonary infarction. Histopathologic study of the lesions revealed broad nonseptate fungal hyphae that had invaded vascular channels, with areas of necrosis and acute inflammation. Primary cutaneous phycomycosis is rare. In the studied cases, dissemination of infection did not occur. The unusual feature of fatal pulmonary dissemination of primary cutaneous phycomycosis as observed in our patient has not been described in the literature. (Arch Dermatol 112:509-512, 1976) References 1. Baker RD: Pulmonary mucormycosis . Am J Pathol 32:287-313, 1956. 2. Hutter RVP: Phycomycetous infection (mucormycosis) in cancer patients: A complication of therapy . Cancer 12:330-350, 1959.Crossref 3. Neame P, Rayner D: Mucormycosis . Arch Pathol 70:261-268, 1960. 4. McBride RA, Corson JM, Dammin GJ: Mucormycosis . Am J Med 28:832-846, 1960.Crossref 5. Ferry AP: Cerebral mucormycosis (phycomycosis): Ocular findings and review of literature . Survey Ophthalmol 6:1-24, 1961. 6. Straatsma BR, Zimmerman LE, Gass JDM: Phycomycosis: A clinicopathological study of 51 cases . Lab Invest 11:963-985, 1962. 7. Meyer RD, Rosen P, Armstrong D: Phycomycosis complicating leukemia and lymphoma . Ann Intern Med 77:871-879, 1972.Crossref 8. Josefiak EJ, Smith Foushee JH, Smith LC: Cutaneous mucormycosis . Am J Clin Pathol 30:547-552, 1958. 9. Roberts HJ: Cutaneous mucormycosis . Arch Intern Med 110:108-112, 1962.Crossref 10. Emmons WC, Binford HC, Utz JP: The Phycomycoses: Medical Mycology . Philadelphia, Lea & Febiger, 1970, pp 230-255. 11. Luna LG: Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology . New York, McGraw-Hill Book Co Inc, 1968, pp 230-232. 12. Baker RD, Seabury JH, Schneidau JD Jr: Subcutaneous and cutaneous mucormycosis and subcutaneous phycomycosis . Lab Invest 11:1091-1102, 1962. 13. Rabin ER, Lundberg GD, Mitchell ET: Mucormycosis in severely burned patients . N Engl J Med 264:1286-1289, 1961.Crossref 14. Meyer RD, Kaplan MH, Ong M, et al: Cutaneous lesions in disseminated mucormycosis . JAMA 225:737-738, 1973.Crossref 15. Millard M: Lung, pleura and mediastinum , in Anderson WAD (ed): Pathology . St. Louis, CV Mosby Co, 1971, vol 2, p 889. 16. Spencer H: Pathology of the Lung . New York, Pergamon Press Inc, 1968, p 586. 17. Hodgson CH, Good CA: Pulmonary embolism and infarction . Med Clin North Am 48:977-992, 1964. 18. Medoff G, Kobayashi GS: Pulmonary mucormycosis . N Engl J Med 286:86-87, 1972.Crossref 19. Gale AM, Kleitsch WP: Solitary pulmonary nodule due to phycomycosis (mucormycosis) . Chest 62:752-755, 1972.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cutaneous Phycomycosis (Mucormycosis) With Fatal Pulmonary Dissemination

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References (25)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630280037009
Publisher site
See Article on Publisher Site

Abstract

Abstract • Phycomycosis of the skin manifested as a spontaneous solitary ulcer of the leg in a patient with uremia. The infection later spread to the lungs and produced fatal pulmonary infarction. Histopathologic study of the lesions revealed broad nonseptate fungal hyphae that had invaded vascular channels, with areas of necrosis and acute inflammation. Primary cutaneous phycomycosis is rare. In the studied cases, dissemination of infection did not occur. The unusual feature of fatal pulmonary dissemination of primary cutaneous phycomycosis as observed in our patient has not been described in the literature. (Arch Dermatol 112:509-512, 1976) References 1. Baker RD: Pulmonary mucormycosis . Am J Pathol 32:287-313, 1956. 2. Hutter RVP: Phycomycetous infection (mucormycosis) in cancer patients: A complication of therapy . Cancer 12:330-350, 1959.Crossref 3. Neame P, Rayner D: Mucormycosis . Arch Pathol 70:261-268, 1960. 4. McBride RA, Corson JM, Dammin GJ: Mucormycosis . Am J Med 28:832-846, 1960.Crossref 5. Ferry AP: Cerebral mucormycosis (phycomycosis): Ocular findings and review of literature . Survey Ophthalmol 6:1-24, 1961. 6. Straatsma BR, Zimmerman LE, Gass JDM: Phycomycosis: A clinicopathological study of 51 cases . Lab Invest 11:963-985, 1962. 7. Meyer RD, Rosen P, Armstrong D: Phycomycosis complicating leukemia and lymphoma . Ann Intern Med 77:871-879, 1972.Crossref 8. Josefiak EJ, Smith Foushee JH, Smith LC: Cutaneous mucormycosis . Am J Clin Pathol 30:547-552, 1958. 9. Roberts HJ: Cutaneous mucormycosis . Arch Intern Med 110:108-112, 1962.Crossref 10. Emmons WC, Binford HC, Utz JP: The Phycomycoses: Medical Mycology . Philadelphia, Lea & Febiger, 1970, pp 230-255. 11. Luna LG: Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology . New York, McGraw-Hill Book Co Inc, 1968, pp 230-232. 12. Baker RD, Seabury JH, Schneidau JD Jr: Subcutaneous and cutaneous mucormycosis and subcutaneous phycomycosis . Lab Invest 11:1091-1102, 1962. 13. Rabin ER, Lundberg GD, Mitchell ET: Mucormycosis in severely burned patients . N Engl J Med 264:1286-1289, 1961.Crossref 14. Meyer RD, Kaplan MH, Ong M, et al: Cutaneous lesions in disseminated mucormycosis . JAMA 225:737-738, 1973.Crossref 15. Millard M: Lung, pleura and mediastinum , in Anderson WAD (ed): Pathology . St. Louis, CV Mosby Co, 1971, vol 2, p 889. 16. Spencer H: Pathology of the Lung . New York, Pergamon Press Inc, 1968, p 586. 17. Hodgson CH, Good CA: Pulmonary embolism and infarction . Med Clin North Am 48:977-992, 1964. 18. Medoff G, Kobayashi GS: Pulmonary mucormycosis . N Engl J Med 286:86-87, 1972.Crossref 19. Gale AM, Kleitsch WP: Solitary pulmonary nodule due to phycomycosis (mucormycosis) . Chest 62:752-755, 1972.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1976

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