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Hypopharyngeal and Laryngeal Involvement With Darier Disease

Hypopharyngeal and Laryngeal Involvement With Darier Disease Abstract The presence of mucosal Darier disease (keratosis follicularis) was evaluated clinically and histologically in four consecutive patients with moderate to extensive cutaneous manifestations of this disease. Fiberoptic endoscopy demonstrated hypopharyngeal or laryngeal involvement or both in each patient. A dearth of corps ronds and grains in these anatomical regions was observed histologically. The routine evaluation of mucosal involvement in Darier disease should result in a higher incidence of hypopharyngeal and laryngeal lesions than is currently known. Furthermore, the recognition of hypopharyngeal and laryngeal involvement with Darier disease must be emphasized because of the clinical similarity to leukoplakia and squamous cell carcinoma. References 1. Gorlin RJ, Chaudhry AP: The oral manifestation of keratosis follicularis . Oral Surg 12:1468-1470, 1959.Crossref 2. Spouge JD, Trott JR, Chesko G: DarierWhite's disease: A cause of white lesions of the mucosa . Oral Surg 21:441-457, 1966.Crossref 3. Weathers DR, Olansky S, Sharpe LO: Darier's disease with mucous membrane involvement: A case report . Arch Dermatol 100:50-53, 1969.Crossref 4. Ellis FA: Keratosis follicularis is not primarily a follicular disease . Arch Dermatol Syphilol 50:27-30, 1944.Crossref 5. Klein A, Burns L, Leyden JJ: Rectal mucosa involvement in keratosis follicularis . Arch Dermatol 109:560-561, 1974.Crossref 6. Brunauer SR: Über Schleimhautveranderungen bei marbus Darier und über die Pathogenese dieser Erkankung . Acta Derm Venereol 6:131-176, 1925. 7. Brunauer SR: Morbus Darier , in Jadassohn J (ed): Handbuch der Haut und Geschlechtskrankheiten . Berlin, Springer-Verlag, 1931, vol 8, pt (2) , pp 210-280. 8. Murtula G, Coassolo M: In tema di manifestazioni mucose nella malattia di Darier . Min Derm 29:88-93, 1954. 9. Fisher ER, Kyler SL: Darier's disease of the larynx . Arch Otolaryngol 62:438-441, 1955.Crossref 10. Smiddy JF, Ruth WE, Kerby GR, et al: Flexible fiberoptic bronchoscopy . Ann Intern Med 75:971, 1971.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Hypopharyngeal and Laryngeal Involvement With Darier Disease

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1975.01630180072009
Publisher site
See Article on Publisher Site

Abstract

Abstract The presence of mucosal Darier disease (keratosis follicularis) was evaluated clinically and histologically in four consecutive patients with moderate to extensive cutaneous manifestations of this disease. Fiberoptic endoscopy demonstrated hypopharyngeal or laryngeal involvement or both in each patient. A dearth of corps ronds and grains in these anatomical regions was observed histologically. The routine evaluation of mucosal involvement in Darier disease should result in a higher incidence of hypopharyngeal and laryngeal lesions than is currently known. Furthermore, the recognition of hypopharyngeal and laryngeal involvement with Darier disease must be emphasized because of the clinical similarity to leukoplakia and squamous cell carcinoma. References 1. Gorlin RJ, Chaudhry AP: The oral manifestation of keratosis follicularis . Oral Surg 12:1468-1470, 1959.Crossref 2. Spouge JD, Trott JR, Chesko G: DarierWhite's disease: A cause of white lesions of the mucosa . Oral Surg 21:441-457, 1966.Crossref 3. Weathers DR, Olansky S, Sharpe LO: Darier's disease with mucous membrane involvement: A case report . Arch Dermatol 100:50-53, 1969.Crossref 4. Ellis FA: Keratosis follicularis is not primarily a follicular disease . Arch Dermatol Syphilol 50:27-30, 1944.Crossref 5. Klein A, Burns L, Leyden JJ: Rectal mucosa involvement in keratosis follicularis . Arch Dermatol 109:560-561, 1974.Crossref 6. Brunauer SR: Über Schleimhautveranderungen bei marbus Darier und über die Pathogenese dieser Erkankung . Acta Derm Venereol 6:131-176, 1925. 7. Brunauer SR: Morbus Darier , in Jadassohn J (ed): Handbuch der Haut und Geschlechtskrankheiten . Berlin, Springer-Verlag, 1931, vol 8, pt (2) , pp 210-280. 8. Murtula G, Coassolo M: In tema di manifestazioni mucose nella malattia di Darier . Min Derm 29:88-93, 1954. 9. Fisher ER, Kyler SL: Darier's disease of the larynx . Arch Otolaryngol 62:438-441, 1955.Crossref 10. Smiddy JF, Ruth WE, Kerby GR, et al: Flexible fiberoptic bronchoscopy . Ann Intern Med 75:971, 1971.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jun 1, 1975

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