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Candidiasis and Multiple Endocrinopathy: With Oral Squamous Cell Carcinoma Complications

Candidiasis and Multiple Endocrinopathy: With Oral Squamous Cell Carcinoma Complications Abstract A 26-year-old man having multiple endocrinopathy (pernicious anemia, hypothyroidism, hypoadrenocorticism, gonadal failure, and diabetes mellitus) and chronic candidiasis developed several rapidly growing primary tumors on the oral mucosa. Histologically, the tumors appeared to be very well differentiated squamous cell carcinomas. Yet, in spite of all therapeutic attempts, the tumors rapidly progressed and within eight months resulted in disseminated carcinomatosis and death. At autopsy the patient was found to have had a miniscule dysplastic thymus. It is postulated that in chronic candidiasis and polyendocrinopathy a defect may exist in immunologic cellular surveillance for recognition and destruction of aberrant cells. References 1. Whitaker J, Landing BH, Esselborn VM, et al: The syndrome of familial juvenile hypoadrenocorticism, hypoparathyroidism and superficial moniliasis . J Clin Endocrinol Metab 16:1374-1387, 1956.Crossref 2. Spinner MW, Blizzard RM, Childs B: Clinical and genetic heterogeneity in idiopathic Addison's disease and hypoparathyroidism . J Clin Endocrinol Metab 28:795-804, 1968.Crossref 3. Wuepper KD, Fudenberg HH: Moniliasis, `autoimmune' polyendocrinopathy and immunologic family study . Clin Exp Immunol 2:71-82, 1967. 4. Morse WI, Cochrane WA, Landrigan PL: Familial hypoparathyroidism with pernicious anemia, steatorrhea and adrenocortical insufficiency . N Engl J Med 264:1021-1026, 1961.Crossref 5. Solomon IL, Blizzard RM: Autoimmune disorders of endocrine glands . J Pediatr 63:1021-1033, 1963.Crossref 6. Waldmann TA, Strober W, Blaese RA: Immunodeficiency diseases and malignancy: Various immunologic deficiencies of man and the role of the immune processes in the control of malignant disease . Ann Intern Med 77:605-628, 1972.Crossref 7. Buzdygan D, Lepper BM, Neuhauser I, et al: Extensive cutaneous moniliasis . Am J Dis Child 102:168-179, 1961.Crossref 8. Solomon LM, Rosenthal I, Klapman M: Tumor of lower lip . Arch Dermatol 101:241-244, 1970.Crossref 9. Archard HO: Common stomatologic disorders , in Fitzpatrick TB, et al (eds): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1971, pp 795-911. 10. Gatti RA, Good RA: Occurrence of malignancy in immunodeficiency diseases: A literature review . Cancer 28:89-98, 1971.Crossref 11. McKhann CF: Primary malignancy in patients undergoing immunosuppression for renal transplantation . Transplantation 8:209-212, 1969.Crossref 12. Feigin RD, Shackelford PG, Eisen S, et al: Treatment of mucocutaneous candidiasis with transfer factor . Pediatrics 53:63-70, 1974. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Candidiasis and Multiple Endocrinopathy: With Oral Squamous Cell Carcinoma Complications

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1975.01630170083013
Publisher site
See Article on Publisher Site

Abstract

Abstract A 26-year-old man having multiple endocrinopathy (pernicious anemia, hypothyroidism, hypoadrenocorticism, gonadal failure, and diabetes mellitus) and chronic candidiasis developed several rapidly growing primary tumors on the oral mucosa. Histologically, the tumors appeared to be very well differentiated squamous cell carcinomas. Yet, in spite of all therapeutic attempts, the tumors rapidly progressed and within eight months resulted in disseminated carcinomatosis and death. At autopsy the patient was found to have had a miniscule dysplastic thymus. It is postulated that in chronic candidiasis and polyendocrinopathy a defect may exist in immunologic cellular surveillance for recognition and destruction of aberrant cells. References 1. Whitaker J, Landing BH, Esselborn VM, et al: The syndrome of familial juvenile hypoadrenocorticism, hypoparathyroidism and superficial moniliasis . J Clin Endocrinol Metab 16:1374-1387, 1956.Crossref 2. Spinner MW, Blizzard RM, Childs B: Clinical and genetic heterogeneity in idiopathic Addison's disease and hypoparathyroidism . J Clin Endocrinol Metab 28:795-804, 1968.Crossref 3. Wuepper KD, Fudenberg HH: Moniliasis, `autoimmune' polyendocrinopathy and immunologic family study . Clin Exp Immunol 2:71-82, 1967. 4. Morse WI, Cochrane WA, Landrigan PL: Familial hypoparathyroidism with pernicious anemia, steatorrhea and adrenocortical insufficiency . N Engl J Med 264:1021-1026, 1961.Crossref 5. Solomon IL, Blizzard RM: Autoimmune disorders of endocrine glands . J Pediatr 63:1021-1033, 1963.Crossref 6. Waldmann TA, Strober W, Blaese RA: Immunodeficiency diseases and malignancy: Various immunologic deficiencies of man and the role of the immune processes in the control of malignant disease . Ann Intern Med 77:605-628, 1972.Crossref 7. Buzdygan D, Lepper BM, Neuhauser I, et al: Extensive cutaneous moniliasis . Am J Dis Child 102:168-179, 1961.Crossref 8. Solomon LM, Rosenthal I, Klapman M: Tumor of lower lip . Arch Dermatol 101:241-244, 1970.Crossref 9. Archard HO: Common stomatologic disorders , in Fitzpatrick TB, et al (eds): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1971, pp 795-911. 10. Gatti RA, Good RA: Occurrence of malignancy in immunodeficiency diseases: A literature review . Cancer 28:89-98, 1971.Crossref 11. McKhann CF: Primary malignancy in patients undergoing immunosuppression for renal transplantation . Transplantation 8:209-212, 1969.Crossref 12. Feigin RD, Shackelford PG, Eisen S, et al: Treatment of mucocutaneous candidiasis with transfer factor . Pediatrics 53:63-70, 1974.

Journal

Archives of Dermatology – American Medical Association

Published: May 1, 1975

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