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Tachyphylaxis to the Action of Topically Applied Corticosteroids

Tachyphylaxis to the Action of Topically Applied Corticosteroids Abstract A previously unrecognized pharmacological event, acute tolerance to the vasoconstrictive action of topically applied glucocorticosteroids, has been discovered in human skin. Thus, potent topical glucocorticosteroids will cause vasoconstriction when first applied to human skin but with subsequent applications the production of vasoconstriction rapidly diminishes. However, after a rest period of a few days, the same initial vasoconstrictive effect may be produced again, but this will also disappear if the steroid is again continued topically. These observations have important applications to optimum timing in the clinical topical use of glucocorticosteroids for maximum therapeutic advantage. References 1. McKenzie AW, Stoughton RB: Method for comparing percutaneous absorption of steroids . Arch Dermatol 86:608-610, 1962.Crossref 2. Stoughton RB: Bioassay system for formulations of topically applied glucocorticosteroids . Arch Dermatol 106:825-827, 1972.Crossref 3. Chen KK, Meek WJ: Further studies of the effect of ephedrine on the circulation . J Pharmacol Exp Ther 28:31-57, 1926. 4. Burn JH, Rand MJ: The action of sympathomimetic amines in animals treated with reserpine . J Physiol 144:314-336, 1958. 5. Fritz I, Levine R: Action of adrenal cortical steroids and norepinephrine on vascular responses of stress in adrenalectomized rats . Am J Physiol 165:456-465, 1951. 6. Solomon LM, Wentzel HE, Greenberg MS: Studies in the mechanism of steroid vasoconstriction . J Invest Dermatol 44:129-131, 1965. 7. Reis DJ: Potentiation of the vasoconstrictor action of topical norepinephrine on the human bulbar conjunctival vessels after topical application of certain adrenocortical hormones . J Clin Endocrinol 20:446-456, 1960.Crossref 8. Frank L, Rapp Y, Biro L, et al: Inflammation mediators and the inflammatory reaction . Arch Dermatol 89:55-67, 1964.Crossref 9. Wolf JE, Hubler WR, Guzick ND: Mechanism of steroid-induced vasoconstriction . Read before the Society for Investigative Dermatology meeting, Chicago, 1974 . 10. Robison GA, Butcher RW, Sutherland EW: Cyclic AMP . New York, Academic Press Inc, 1970, pp 204-210. 11. Schultz G, Hardman JG, Schultz K, et al: The importance of calcium ions for the regulation of guanosine 3′:5′-cyclic monophosphate levels . Proc Natl Acad Sci USA 70:3889-3893, 1973.Crossref 12. Lobitz WC, Campbell CJ: Physiologic studies in atopic dermatitis . Arch Dermatol 67:575-589, 1953. 13. Stoughton RB, DeOreo G, Clendenning W: Effects of intradermal injection of vasopressors in normal and diseased skin . Arch Dermatol 82:400-407, 1960.Crossref 14. Fisher LB, Maibach HI: The effect of corticosteroids on human epidermal mitotic activity . Arch Dermatol 103:39-44, 1971.Crossref 15. Fry L, McMinn RMH: The action of chemotherapeutic agents on psoriatic epidermis . Br J Dermatol 80:373-383, 1968.Crossref 16. Baxter D, Stoughton RB: Mitotic index of psoriatic lesions treated with anthralin, glucocorticosteroid and occlusion only . J Invest Dermatol 54:410-412, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Tachyphylaxis to the Action of Topically Applied Corticosteroids

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References (18)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1975.01630170039002
Publisher site
See Article on Publisher Site

Abstract

Abstract A previously unrecognized pharmacological event, acute tolerance to the vasoconstrictive action of topically applied glucocorticosteroids, has been discovered in human skin. Thus, potent topical glucocorticosteroids will cause vasoconstriction when first applied to human skin but with subsequent applications the production of vasoconstriction rapidly diminishes. However, after a rest period of a few days, the same initial vasoconstrictive effect may be produced again, but this will also disappear if the steroid is again continued topically. These observations have important applications to optimum timing in the clinical topical use of glucocorticosteroids for maximum therapeutic advantage. References 1. McKenzie AW, Stoughton RB: Method for comparing percutaneous absorption of steroids . Arch Dermatol 86:608-610, 1962.Crossref 2. Stoughton RB: Bioassay system for formulations of topically applied glucocorticosteroids . Arch Dermatol 106:825-827, 1972.Crossref 3. Chen KK, Meek WJ: Further studies of the effect of ephedrine on the circulation . J Pharmacol Exp Ther 28:31-57, 1926. 4. Burn JH, Rand MJ: The action of sympathomimetic amines in animals treated with reserpine . J Physiol 144:314-336, 1958. 5. Fritz I, Levine R: Action of adrenal cortical steroids and norepinephrine on vascular responses of stress in adrenalectomized rats . Am J Physiol 165:456-465, 1951. 6. Solomon LM, Wentzel HE, Greenberg MS: Studies in the mechanism of steroid vasoconstriction . J Invest Dermatol 44:129-131, 1965. 7. Reis DJ: Potentiation of the vasoconstrictor action of topical norepinephrine on the human bulbar conjunctival vessels after topical application of certain adrenocortical hormones . J Clin Endocrinol 20:446-456, 1960.Crossref 8. Frank L, Rapp Y, Biro L, et al: Inflammation mediators and the inflammatory reaction . Arch Dermatol 89:55-67, 1964.Crossref 9. Wolf JE, Hubler WR, Guzick ND: Mechanism of steroid-induced vasoconstriction . Read before the Society for Investigative Dermatology meeting, Chicago, 1974 . 10. Robison GA, Butcher RW, Sutherland EW: Cyclic AMP . New York, Academic Press Inc, 1970, pp 204-210. 11. Schultz G, Hardman JG, Schultz K, et al: The importance of calcium ions for the regulation of guanosine 3′:5′-cyclic monophosphate levels . Proc Natl Acad Sci USA 70:3889-3893, 1973.Crossref 12. Lobitz WC, Campbell CJ: Physiologic studies in atopic dermatitis . Arch Dermatol 67:575-589, 1953. 13. Stoughton RB, DeOreo G, Clendenning W: Effects of intradermal injection of vasopressors in normal and diseased skin . Arch Dermatol 82:400-407, 1960.Crossref 14. Fisher LB, Maibach HI: The effect of corticosteroids on human epidermal mitotic activity . Arch Dermatol 103:39-44, 1971.Crossref 15. Fry L, McMinn RMH: The action of chemotherapeutic agents on psoriatic epidermis . Br J Dermatol 80:373-383, 1968.Crossref 16. Baxter D, Stoughton RB: Mitotic index of psoriatic lesions treated with anthralin, glucocorticosteroid and occlusion only . J Invest Dermatol 54:410-412, 1970.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: May 1, 1975

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