Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cicatricial Pemphigoid: Immunofluorescent Studies

Cicatricial Pemphigoid: Immunofluorescent Studies Abstract Twelve cases of cicatricial pemphigoid, eight of which have not been previously reported, were studied using immunofluorescence. In 9 of the 12 patients, immunoglobulin could be demonstrated at the basement membrane zone (BMZ) of the skin, oral mucosa, or conjunctiva. The sera from 10 of the 12 patients was examined by indirect immunofluorescence using nine different substrate tissues as well as the patient's own normal skin and normal oral mucosa when negative on direct immunofluorescence. Three of the sera contained BMZ antibody; however, these antibodies exhibited certain substrate tissue specificities that may partially account for the small number of sera from patients with cicatricial pemphigoid in which BMZ antibody can be detected. The demonstration of these antibodies is further evidence that cicatricial pemphigoid and bullous pemphigoid may represent variants of the same basic disease process. References 1. Lever WF: Pemphigus and Pemphigoid . Springfield Ill, Charles C Thomas Publisher, 1965. 2. Hardy KM, et al: Benign mucous membrane pemphigoid . Arch Dermatol 104:467-475, 1971.Crossref 3. Beutner EH, Chorzelski TP, Jordon RE: Autosensitization in Pemphigus and Bullous Pemphigoid . Springfield Ill, Charles C Thomas Publisher, 1970. 4. Bean SF, et al: Cicatricial pemphigoid: Immunofluorescent studies . Arch Dermatol 106:195-199, 1972.Crossref 5. Holubar K, Honigsmann H, Wolf K: Cicatricial pemphigoid . Arch Dermatol 108:50-52, 1973.Crossref 6. Dantzig P: Circulating antibodies in cicatricial pemphigoid . Arch Dermatol 108:264-266, 1973.Crossref 7. Chorzelski TP, Beutner EH: Factors contributing to occasional failures in the laboratory diagnosis of bullous pemphigoid by indirect immunofluorescence . Br J Dermatol 86:111-117, 1972.Crossref 8. Sams WM Jr: Immunofluorescence in dermatology , in Year Book of Dermatology . Chicago, Year Book Medical Publishers, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cicatricial Pemphigoid: Immunofluorescent Studies

Bean, Samuel F.
Archives of Dermatology , Volume 110 (4) – Oct 1, 1974
Download PDF
4 pages

Loading next page...
 
/lp/american-medical-association/cicatricial-pemphigoid-immunofluorescent-studies-aroKdwBxUb

References (8)

Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1974.01630100012002
Publisher site
See Article on Publisher Site

Abstract

Abstract Twelve cases of cicatricial pemphigoid, eight of which have not been previously reported, were studied using immunofluorescence. In 9 of the 12 patients, immunoglobulin could be demonstrated at the basement membrane zone (BMZ) of the skin, oral mucosa, or conjunctiva. The sera from 10 of the 12 patients was examined by indirect immunofluorescence using nine different substrate tissues as well as the patient's own normal skin and normal oral mucosa when negative on direct immunofluorescence. Three of the sera contained BMZ antibody; however, these antibodies exhibited certain substrate tissue specificities that may partially account for the small number of sera from patients with cicatricial pemphigoid in which BMZ antibody can be detected. The demonstration of these antibodies is further evidence that cicatricial pemphigoid and bullous pemphigoid may represent variants of the same basic disease process. References 1. Lever WF: Pemphigus and Pemphigoid . Springfield Ill, Charles C Thomas Publisher, 1965. 2. Hardy KM, et al: Benign mucous membrane pemphigoid . Arch Dermatol 104:467-475, 1971.Crossref 3. Beutner EH, Chorzelski TP, Jordon RE: Autosensitization in Pemphigus and Bullous Pemphigoid . Springfield Ill, Charles C Thomas Publisher, 1970. 4. Bean SF, et al: Cicatricial pemphigoid: Immunofluorescent studies . Arch Dermatol 106:195-199, 1972.Crossref 5. Holubar K, Honigsmann H, Wolf K: Cicatricial pemphigoid . Arch Dermatol 108:50-52, 1973.Crossref 6. Dantzig P: Circulating antibodies in cicatricial pemphigoid . Arch Dermatol 108:264-266, 1973.Crossref 7. Chorzelski TP, Beutner EH: Factors contributing to occasional failures in the laboratory diagnosis of bullous pemphigoid by indirect immunofluorescence . Br J Dermatol 86:111-117, 1972.Crossref 8. Sams WM Jr: Immunofluorescence in dermatology , in Year Book of Dermatology . Chicago, Year Book Medical Publishers, 1973.

Journal

Archives of Dermatology – American Medical Association

Published: Oct 1, 1974

There are no references for this article.