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Lupus Erythematosus and Porphyria: Coexistence in Seven Patients

Lupus Erythematosus and Porphyria: Coexistence in Seven Patients Abstract Lupus erythematosus (LE) and porphyria can occur together in the same patient and present special problems in diagnosis and management. At least 17 cases of coexisting LE and porphyria have been reported in the literature and this report describes in detail seven additional patients with this combination. The intriguing question is whether the two diseases might be present by some common pathogenic mechanism, but as yet, any etiologic relationship is unclear. The increasing number of reports in the literature indicates that physicians caring for patients with either LE or porphyria should be alert to signs or symptoms suggesting this dual disease process. This is especially important when considering the course of therapy. References 1. Wolfram S: Uber porphyrinkolik: Ein beitrag zur symptomatologie des erythematodes acutus . Hautarzt 3:298-300, 1952. 2. Linden IH, et al: Development of porphyria during chloroquine therapy for chronic discoid lupus erythematosus . Calif Med 81:235-238, 1954. 3. Porphyria cutanea tarda: Chronic discoid lupus erythematosus, SOCIETY TRANSACTIONS . Arch Dermatol 71:278, 1955. 4. Davis MJ, Vander Ploeg DE: Acute porphyria and coproporphyrinuria following chloroquine therapy . Arch Dermatol 75:796-800, 1957.Crossref 5. Marsden CW: Porphyria during chloroquine therapy . Br J Dermatol 71:219-222, 1959.Crossref 6. Vickers CFH, Sneddon IB: Subacute systemic lupus erythematosus: Prophyria . Br J Dermatol 74:155-156, 1962. 7. Passaron N, Lloveras JH, Vasquez E: Lupus eritematoso cronico exacerbado y porfiria aguda . Arch Argent Dermatol 12:299-303, 1962. 8. Cripps DJ, Curtis AC: Toxic effect of chloroquine on porphyria hepatica . Arch Dermatol 86: 575-581, 1962.Crossref 9. Harris MY, Mills GC, Levin WC: Coexistent systemic lupus erythematosus and porphyria . Arch Intern Med 117:425-428, 1966.Crossref 10. Gordon W: The cutaneous lesions of systemic and chronic discoid lupus erythematosus and porphyria symptomatica in the same patient . Br J Dermatol 78:53-54, 1966.Crossref 11. Porphyria cutanea tarda: Lupus erythematosus? SOCIETY TRANSACTIONS . Arch Dermatol 93:382, 1966. 12. Duperrat B, et al: Porphyria cutanee tardive et lupus erythemateux chez une splenectomisee . Bull Soc Fr Dermatol Syphiligr 75:424, 1968. 13. Hetherington GW, Jettor RL, Knox JM: The association of lupus erythematosus and porphyria . Br J Dermatol 82:118-124, 1970.Crossref 14. Haneke VE, Schwartze G: Gleichzeitiges Vorkommen von Porphyria cutanea tarda und Erythematodes chronicus . Dermatol Monatsschr 157:168-174, 1971. 15. Tio TH, et al: Auto-immunity and cutaneous porphyria . S Afr J Lab Clin Med (special issue), (Sept) 1971, pp 199-201. 16. Roenigk HH Jr, Gottlob ME: Estrogeninduced porphyria cutanea tarda . Arch Dermatol 102:260-266, 1970.Crossref 17. Chapel TA, Burns RE: Oral contraceptives and exacerbation of lupus erythematosus . Am J Obstet Gynecol 110:366-369, 1971. 18. Kay DR, Bole GG, Ledger WJ: Antinuclear antibodies, rheumatoid factor and C-reactive protein in serum of normal women using oral contraceptives . Arthritis Rheum 14:239-247, 1971.Crossref 19. Felsher BF, Redeker AG: Effect of chloroquine on hepatic uroporphyrin metabolism in patients with porphyria cutanea tarda . Medicine 45:575-583, 1966.Crossref 20. Vogler WR, Galambos JT, Olansky S: Biochemical effects of chloroquine therapy in porphyria cutanea tarda . Am J Med 49:316-321, 1970.Crossref 21. Taljaard JJF, et al: Studies on low dose chloroquine therapy and the action of chloroquine in symptomatic porphyria . Br J Dermatol 87:261-269, 1972.Crossref 22. Kowertz MJ: The therapeutic effect of chloroquine: Hepatic recovery in porphyria cutanea tarda . JAMA 223:515-519, 1973.Crossref 23. Bloom M: Porphyria cutanea tarda treated with chloroquine phosphate . Arch Dermatol 100:375-376, 1969.Crossref 24. Epstein JH, Redeker AG: Porphyria cutanea tarda: A study of the effect of phlebotomy . N Engl J Med 279:1301-1304, 1968.Crossref 25. Cormane RH, Szabo E, Tio TH: Histopathology of the skin in acquired and hereditary porphyria cutanea tarda . Br J Dermatol 85:531-539, 1971.Crossref 26. Epstein JH, Tuffanelli DL, Epstein WL: Cutaneous changes in the porphyrias: A microscopic study . Arch Dermatol 107:689-698, 1973.Crossref 27. Gajdos A, et al: Porphyrie cutanee: Manifestations hematologiques et infections repetees chez un jeune enfant . Rev Fr Etudes Clin Biol 8: 386-392, 1963. 28. Bousser T, et al: Porphyrie cutanee de l'adulte apparue apres une anemie hemolytique a auto-anticorps . Bull Soc Med Hop Paris 114:665-671, 1963. 29. Christensen KN, Torben K: Latent cutaneous porphyria, type PCT, in a caucasian woman . Am J Med 53:517-520, 1972.Crossref 30. Steiner H, et al: Porphyria cutanea tarda, sclerodermie, leukopenie und hemolytische anemie . Schweiz Med Wochenschr 17:538-546, 1967. 31. Taylor JS: Porphyria cutanea tarda symptomatica . Cutis 6:1261-1274, 1970. 32. Bariety M, et al.: Coexistence d'une porphyrie cutanee et d'un thymome pseudo-seminomateux . Bull Soc Med Hop Paris 78:607, 1962. 33. Saeed-uz-Zafer M, Gronewald WR, Bluhm GB: Co-existent Klinefelter's syndrome, acquired cutaneous hepatic porphyria and systemic lupus erythematosus . Henry Ford Hosp Med J 17:227-232, 1970. 34. Engelberth O, et al: Autoantibodies in chromatin-positive men . Lancet 2:1194, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Lupus Erythematosus and Porphyria: Coexistence in Seven Patients

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References (38)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1973.01620270005001
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Abstract

Abstract Lupus erythematosus (LE) and porphyria can occur together in the same patient and present special problems in diagnosis and management. At least 17 cases of coexisting LE and porphyria have been reported in the literature and this report describes in detail seven additional patients with this combination. The intriguing question is whether the two diseases might be present by some common pathogenic mechanism, but as yet, any etiologic relationship is unclear. The increasing number of reports in the literature indicates that physicians caring for patients with either LE or porphyria should be alert to signs or symptoms suggesting this dual disease process. This is especially important when considering the course of therapy. References 1. Wolfram S: Uber porphyrinkolik: Ein beitrag zur symptomatologie des erythematodes acutus . Hautarzt 3:298-300, 1952. 2. Linden IH, et al: Development of porphyria during chloroquine therapy for chronic discoid lupus erythematosus . Calif Med 81:235-238, 1954. 3. Porphyria cutanea tarda: Chronic discoid lupus erythematosus, SOCIETY TRANSACTIONS . Arch Dermatol 71:278, 1955. 4. Davis MJ, Vander Ploeg DE: Acute porphyria and coproporphyrinuria following chloroquine therapy . Arch Dermatol 75:796-800, 1957.Crossref 5. Marsden CW: Porphyria during chloroquine therapy . Br J Dermatol 71:219-222, 1959.Crossref 6. Vickers CFH, Sneddon IB: Subacute systemic lupus erythematosus: Prophyria . Br J Dermatol 74:155-156, 1962. 7. Passaron N, Lloveras JH, Vasquez E: Lupus eritematoso cronico exacerbado y porfiria aguda . Arch Argent Dermatol 12:299-303, 1962. 8. Cripps DJ, Curtis AC: Toxic effect of chloroquine on porphyria hepatica . Arch Dermatol 86: 575-581, 1962.Crossref 9. Harris MY, Mills GC, Levin WC: Coexistent systemic lupus erythematosus and porphyria . Arch Intern Med 117:425-428, 1966.Crossref 10. Gordon W: The cutaneous lesions of systemic and chronic discoid lupus erythematosus and porphyria symptomatica in the same patient . Br J Dermatol 78:53-54, 1966.Crossref 11. Porphyria cutanea tarda: Lupus erythematosus? SOCIETY TRANSACTIONS . Arch Dermatol 93:382, 1966. 12. Duperrat B, et al: Porphyria cutanee tardive et lupus erythemateux chez une splenectomisee . Bull Soc Fr Dermatol Syphiligr 75:424, 1968. 13. Hetherington GW, Jettor RL, Knox JM: The association of lupus erythematosus and porphyria . Br J Dermatol 82:118-124, 1970.Crossref 14. Haneke VE, Schwartze G: Gleichzeitiges Vorkommen von Porphyria cutanea tarda und Erythematodes chronicus . Dermatol Monatsschr 157:168-174, 1971. 15. Tio TH, et al: Auto-immunity and cutaneous porphyria . S Afr J Lab Clin Med (special issue), (Sept) 1971, pp 199-201. 16. Roenigk HH Jr, Gottlob ME: Estrogeninduced porphyria cutanea tarda . Arch Dermatol 102:260-266, 1970.Crossref 17. Chapel TA, Burns RE: Oral contraceptives and exacerbation of lupus erythematosus . Am J Obstet Gynecol 110:366-369, 1971. 18. Kay DR, Bole GG, Ledger WJ: Antinuclear antibodies, rheumatoid factor and C-reactive protein in serum of normal women using oral contraceptives . Arthritis Rheum 14:239-247, 1971.Crossref 19. Felsher BF, Redeker AG: Effect of chloroquine on hepatic uroporphyrin metabolism in patients with porphyria cutanea tarda . Medicine 45:575-583, 1966.Crossref 20. Vogler WR, Galambos JT, Olansky S: Biochemical effects of chloroquine therapy in porphyria cutanea tarda . Am J Med 49:316-321, 1970.Crossref 21. Taljaard JJF, et al: Studies on low dose chloroquine therapy and the action of chloroquine in symptomatic porphyria . Br J Dermatol 87:261-269, 1972.Crossref 22. Kowertz MJ: The therapeutic effect of chloroquine: Hepatic recovery in porphyria cutanea tarda . JAMA 223:515-519, 1973.Crossref 23. Bloom M: Porphyria cutanea tarda treated with chloroquine phosphate . Arch Dermatol 100:375-376, 1969.Crossref 24. Epstein JH, Redeker AG: Porphyria cutanea tarda: A study of the effect of phlebotomy . N Engl J Med 279:1301-1304, 1968.Crossref 25. Cormane RH, Szabo E, Tio TH: Histopathology of the skin in acquired and hereditary porphyria cutanea tarda . Br J Dermatol 85:531-539, 1971.Crossref 26. Epstein JH, Tuffanelli DL, Epstein WL: Cutaneous changes in the porphyrias: A microscopic study . Arch Dermatol 107:689-698, 1973.Crossref 27. Gajdos A, et al: Porphyrie cutanee: Manifestations hematologiques et infections repetees chez un jeune enfant . Rev Fr Etudes Clin Biol 8: 386-392, 1963. 28. Bousser T, et al: Porphyrie cutanee de l'adulte apparue apres une anemie hemolytique a auto-anticorps . Bull Soc Med Hop Paris 114:665-671, 1963. 29. Christensen KN, Torben K: Latent cutaneous porphyria, type PCT, in a caucasian woman . Am J Med 53:517-520, 1972.Crossref 30. Steiner H, et al: Porphyria cutanea tarda, sclerodermie, leukopenie und hemolytische anemie . Schweiz Med Wochenschr 17:538-546, 1967. 31. Taylor JS: Porphyria cutanea tarda symptomatica . Cutis 6:1261-1274, 1970. 32. Bariety M, et al.: Coexistence d'une porphyrie cutanee et d'un thymome pseudo-seminomateux . Bull Soc Med Hop Paris 78:607, 1962. 33. Saeed-uz-Zafer M, Gronewald WR, Bluhm GB: Co-existent Klinefelter's syndrome, acquired cutaneous hepatic porphyria and systemic lupus erythematosus . Henry Ford Hosp Med J 17:227-232, 1970. 34. Engelberth O, et al: Autoantibodies in chromatin-positive men . Lancet 2:1194, 1966.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Dec 1, 1973

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