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Dopa and Oxidases

Dopa and Oxidases This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— We are grateful to Dr. Okun for his detailed consideration of dopa and tyrosine oxidases. In our study of lichen planus we observed a striking reduction of dopa-positive melanocytes in the basal region of the epidermis where the lichen planus was active. In the dermal infiltrate we observed a few weekly dopa-positive cells, but we were unconvinced that any of these represented dendritic melanocytes. We did not have the opportunity of preincubating our sections with sodium diethyldithiocarbamate and adding catalase to the incubation medium to distinguish a peroxidase-dependent dopa reaction from a tyrosinase-dependent reaction. We certainly in no way wished to imply any "commitment to the unproven and highly questionable hypothesis that mammalian melanogenesis is based on the catalysis of a single aerobic oxidase" as Dr. Okun has suggested. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Dopa and Oxidases

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Dopa and Oxidases

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— We are grateful to Dr. Okun for his detailed consideration of dopa and tyrosine oxidases. In our study of lichen planus we observed a striking reduction of dopa-positive melanocytes in the basal region of the epidermis where the lichen planus was active. In the dermal infiltrate we observed a few weekly dopa-positive cells, but we...
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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1972.01620120096035
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— We are grateful to Dr. Okun for his detailed consideration of dopa and tyrosine oxidases. In our study of lichen planus we observed a striking reduction of dopa-positive melanocytes in the basal region of the epidermis where the lichen planus was active. In the dermal infiltrate we observed a few weekly dopa-positive cells, but we were unconvinced that any of these represented dendritic melanocytes. We did not have the opportunity of preincubating our sections with sodium diethyldithiocarbamate and adding catalase to the incubation medium to distinguish a peroxidase-dependent dopa reaction from a tyrosinase-dependent reaction. We certainly in no way wished to imply any "commitment to the unproven and highly questionable hypothesis that mammalian melanogenesis is based on the catalysis of a single aerobic oxidase" as Dr. Okun has suggested.

Journal

Archives of Dermatology – American Medical Association

Published: Sep 1, 1972

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