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Hair Growth and Alopecia in Hypothyroidism

Hair Growth and Alopecia in Hypothyroidism Abstract The relative proportions of telogen (club) to anagen (growing) hairs in the scalp were examined in hypothyroid subjects with hair loss to asses the basis for the alopecia which occurs when thyroid hormone is lacking. Patients with spontaneous as well as iatrogenic myxedema were examined and serial measurements were secured during restoration of eumetabolism. In all instances, deficiency of thyroid hormone was associated with an increase in the percentage of telogen hairs. Normal telogen-anagen hair relationships were restored during replacement therapy with thyroid hormone; this response was elicited even during the concurrent administration of antithyroid drugs (ie, thiourylenes). The response to treatment with thyroid hormone and the temporal correlations indicate that the alopecia is mediated via effects of the hormone on the initiation as well as the duration of hair growth. References 1. Freinkel R K, Freinkel N: Dermatologic Manifestations of Endoerine Disorders: Dermatology in General Medicine . TB Fitzpatrick, et al, New York, McGraw-Hill Book Co Inc, 1971, pp 1439-1443. 2. Lundback K: Toxic, allergic and "myxedematoid" symptoms in the treatment of thyrotoxicosis with anti-thyroid substances (thiourea, thiouracil, methylthiouracil) . Acta Med Scand 124:266-281, 1946.Crossref 3. Wilburne M: Hair loss and pigmentation due to thiouracil derivatives . JAMA 147:379-380, 1951.Crossref 4. Papadopoulos S, Harden R: Hair loss in patients treated with carbimazole . Brit Med J 2:1502-1503, 1966.Crossref 5. Van Scott EJ, Reinertson RP, Steinmuller R: The growing roots of the human scalp and morphological changes therein following amethopeterin therapy . J Invest Derm 29:197-204, 1957.Crossref 6. Kligman AM: Pathologic dynamics of human hair loss . Arch Derm 83:175-198, 1961.Crossref 7. Smith JG, Weinstein GD, Burr JM: Hair roots of the human scalp in thyroid disease . J Invest Derm 32:35-38, 1959. 8. Barman JM, Astore I, Pecoraro V: The normal trichogram of people over 50 years but apparently not bald , in Montagna W, Dobson RL (eds): Advances in Biology of Skin . Oxford, England, Pergamon Press, 1967, vol 9, pp 211-220. 9. Mohn MP: Effects of different hormonal states in the growth of hair in rats , in Montagna W, Ellis R (eds): The Biology of Hair Growth . New York, Academic Press Inc, 1958, chap 15. 10. Ebling FJ, Hale PA, Johnson E: Hormonal influence on hair growth , in Proceedings of the Second International Congress of Endocrinology . Amsterdam, Excerpta Medica Foundation, 1965, pp 411-415. 11. Montagna W: Histology and cytochemistry of human skin: The eyebrows . Arch Derm 101:257-263, 1970.Crossref 12. Van Scott EJ: Keratinization and hair growth . Ann Rev Med 19:337-350, 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Hair Growth and Alopecia in Hypothyroidism

Archives of Dermatology , Volume 106 (3) – Sep 1, 1972

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1972.01620120037007
Publisher site
See Article on Publisher Site

Abstract

Abstract The relative proportions of telogen (club) to anagen (growing) hairs in the scalp were examined in hypothyroid subjects with hair loss to asses the basis for the alopecia which occurs when thyroid hormone is lacking. Patients with spontaneous as well as iatrogenic myxedema were examined and serial measurements were secured during restoration of eumetabolism. In all instances, deficiency of thyroid hormone was associated with an increase in the percentage of telogen hairs. Normal telogen-anagen hair relationships were restored during replacement therapy with thyroid hormone; this response was elicited even during the concurrent administration of antithyroid drugs (ie, thiourylenes). The response to treatment with thyroid hormone and the temporal correlations indicate that the alopecia is mediated via effects of the hormone on the initiation as well as the duration of hair growth. References 1. Freinkel R K, Freinkel N: Dermatologic Manifestations of Endoerine Disorders: Dermatology in General Medicine . TB Fitzpatrick, et al, New York, McGraw-Hill Book Co Inc, 1971, pp 1439-1443. 2. Lundback K: Toxic, allergic and "myxedematoid" symptoms in the treatment of thyrotoxicosis with anti-thyroid substances (thiourea, thiouracil, methylthiouracil) . Acta Med Scand 124:266-281, 1946.Crossref 3. Wilburne M: Hair loss and pigmentation due to thiouracil derivatives . JAMA 147:379-380, 1951.Crossref 4. Papadopoulos S, Harden R: Hair loss in patients treated with carbimazole . Brit Med J 2:1502-1503, 1966.Crossref 5. Van Scott EJ, Reinertson RP, Steinmuller R: The growing roots of the human scalp and morphological changes therein following amethopeterin therapy . J Invest Derm 29:197-204, 1957.Crossref 6. Kligman AM: Pathologic dynamics of human hair loss . Arch Derm 83:175-198, 1961.Crossref 7. Smith JG, Weinstein GD, Burr JM: Hair roots of the human scalp in thyroid disease . J Invest Derm 32:35-38, 1959. 8. Barman JM, Astore I, Pecoraro V: The normal trichogram of people over 50 years but apparently not bald , in Montagna W, Dobson RL (eds): Advances in Biology of Skin . Oxford, England, Pergamon Press, 1967, vol 9, pp 211-220. 9. Mohn MP: Effects of different hormonal states in the growth of hair in rats , in Montagna W, Ellis R (eds): The Biology of Hair Growth . New York, Academic Press Inc, 1958, chap 15. 10. Ebling FJ, Hale PA, Johnson E: Hormonal influence on hair growth , in Proceedings of the Second International Congress of Endocrinology . Amsterdam, Excerpta Medica Foundation, 1965, pp 411-415. 11. Montagna W: Histology and cytochemistry of human skin: The eyebrows . Arch Derm 101:257-263, 1970.Crossref 12. Van Scott EJ: Keratinization and hair growth . Ann Rev Med 19:337-350, 1968.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1972

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