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Multiple Clear-Cell Acanthoma and Ichthyosis

Multiple Clear-Cell Acanthoma and Ichthyosis Abstract One patient with lamellar ichthyosis and one patient with ichthyosis vulgaris, both with multiple clear-cell acanthomas on the lower extremities, were studied. Histologic examination showed the typical findings of clear-cell acanthoma, plus intraepidermal nests composed of cell debris and inflammatory cells. Histochemical studies revealed increased dendritic cells with intense nucleotide triphosphatase and acid phosphatase activities. The dendritic cells also contained neutral lipids, well demonstrated by oil red O stain. Electron microscopic examination revealed, in addition to glycogen-containing epidermal cells, dendritic cells and processes in the intercellular spaces. Although indeterminate dendritic cells were found, many contained Langerhans granules and lysosomes. Leukocytes and products of cell degradation were seen in the intercellular spaces, often in relation to the leukocyte nests. Mast cells were observed in the epidermis. References 1. Degos R, Civatte J: Clear-cell acanthoma: Experience of eight years . Brit J Derm 83:248-254, 1970.Crossref 2. Takeuchi T, Kuriaki H: Histochemical detection of phosphorylase in animal tissues . J Histochem Cytochem 3:153-160, 1955.Crossref 3. Nachlas MM, Tsou K-C, De Souza E, et al: Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenyl substituted ditetrazole . J Histochem Cytochem 5:420-436, 1957.Crossref 4. Burstone MS: Histochemical demonstration of cytochrome oxidase with amine reagents . J Histochem Cytochem 8:63-70, 1960.Crossref 5. Glenner GG, Burtner HJ, Brown GW Jr: The histochemical demonstration of monoamine oxidase activity by tetrazolium salts . J Histochem Cytochem 5:591-600, 1957.Crossref 6. Nachlas MM, Crawford DT, Seligman AM: The histochemical demonstration of leucine aminopeptidase . J Histochem Cytochem 5:264-278, 1957.Crossref 7. Nachlas MM, Monis B, Rosenblatt D, et al: Improvement in the histochemical localization of leucine aminopeptidase with a new substrate, l-leucyl-4-methoxy-2-naphthylamide . J Biophys Biochem Cytol 7:261-264, 1960.Crossref 8. Pearson B, Grose F: Further histochemical studies of esterases by 5-bromoindoxyl acetate: I. Reference to nonspecific and nonenzymatic hydrolysis . Arch Path 67:324-332, 1959. 9. Pearse AGE: Histochemistry: Theoretical and Applied , ed 2. Boston, Little Brown & Co, 1960, p 807. 10. Gomori G: Microscopic Histochemistry: Principles and Practice . Chicago, University of Chicago Press, 1952, p 273. 11. Wachstein M, Meisel E: Histochemistry of hepatic phosphatases at a physiologic pH: With special reference to the demonstration of bile canaliculi . Amer J Clin Path 27:13-23, 1957. 12. Lerner AB, Fitzpatrick TB: Biochemistry of melanin formation . Physiol Rev 30:91-126, 1950. 13. Fitzpatrick TB, Becker SW Jr, Lerner AB, et al: Tyrosinase in human skin: Demonstration of its presence and of its role in human melanin formation . Science 112:223-225, 1950.Crossref 14. Saunders T: Clear cell acanthoma . Read before the American Dermatological Association, Scottsdale, Ariz, 1969 . 15. Wells GC, Wilson-Jones E: Degos' acanthoma (acanthome a cellules claires): A report of five cases with particular reference to the histochemistry . Brit J Derm 79:249-258, 1967.Crossref 16. Vandersteen PR: The Ichthyosiform Dermatoses: A Clinical, Genetic, Enzyme Histochemical, and Ultrastructural Study, thesis. University of Minnesota, Rochester, 1970. 17. Dimitrova J: Acanthoma clarocellulare . Derm Venerol 5:193-197, 1966. 18. Abulafia J, Grinspan D, Casas JG, et al: Acantoma de celulas claras . Arch Argent Derm 16:278-289, 1966. 19. Wilson-Jones E, Wells GC: Degos' acanthoma (acanthome a cellules claires) . Arch Derm 94:286-294, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Multiple Clear-Cell Acanthoma and Ichthyosis

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1972.01620060013003
Publisher site
See Article on Publisher Site

Abstract

Abstract One patient with lamellar ichthyosis and one patient with ichthyosis vulgaris, both with multiple clear-cell acanthomas on the lower extremities, were studied. Histologic examination showed the typical findings of clear-cell acanthoma, plus intraepidermal nests composed of cell debris and inflammatory cells. Histochemical studies revealed increased dendritic cells with intense nucleotide triphosphatase and acid phosphatase activities. The dendritic cells also contained neutral lipids, well demonstrated by oil red O stain. Electron microscopic examination revealed, in addition to glycogen-containing epidermal cells, dendritic cells and processes in the intercellular spaces. Although indeterminate dendritic cells were found, many contained Langerhans granules and lysosomes. Leukocytes and products of cell degradation were seen in the intercellular spaces, often in relation to the leukocyte nests. Mast cells were observed in the epidermis. References 1. Degos R, Civatte J: Clear-cell acanthoma: Experience of eight years . Brit J Derm 83:248-254, 1970.Crossref 2. Takeuchi T, Kuriaki H: Histochemical detection of phosphorylase in animal tissues . J Histochem Cytochem 3:153-160, 1955.Crossref 3. Nachlas MM, Tsou K-C, De Souza E, et al: Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenyl substituted ditetrazole . J Histochem Cytochem 5:420-436, 1957.Crossref 4. Burstone MS: Histochemical demonstration of cytochrome oxidase with amine reagents . J Histochem Cytochem 8:63-70, 1960.Crossref 5. Glenner GG, Burtner HJ, Brown GW Jr: The histochemical demonstration of monoamine oxidase activity by tetrazolium salts . J Histochem Cytochem 5:591-600, 1957.Crossref 6. Nachlas MM, Crawford DT, Seligman AM: The histochemical demonstration of leucine aminopeptidase . J Histochem Cytochem 5:264-278, 1957.Crossref 7. Nachlas MM, Monis B, Rosenblatt D, et al: Improvement in the histochemical localization of leucine aminopeptidase with a new substrate, l-leucyl-4-methoxy-2-naphthylamide . J Biophys Biochem Cytol 7:261-264, 1960.Crossref 8. Pearson B, Grose F: Further histochemical studies of esterases by 5-bromoindoxyl acetate: I. Reference to nonspecific and nonenzymatic hydrolysis . Arch Path 67:324-332, 1959. 9. Pearse AGE: Histochemistry: Theoretical and Applied , ed 2. Boston, Little Brown & Co, 1960, p 807. 10. Gomori G: Microscopic Histochemistry: Principles and Practice . Chicago, University of Chicago Press, 1952, p 273. 11. Wachstein M, Meisel E: Histochemistry of hepatic phosphatases at a physiologic pH: With special reference to the demonstration of bile canaliculi . Amer J Clin Path 27:13-23, 1957. 12. Lerner AB, Fitzpatrick TB: Biochemistry of melanin formation . Physiol Rev 30:91-126, 1950. 13. Fitzpatrick TB, Becker SW Jr, Lerner AB, et al: Tyrosinase in human skin: Demonstration of its presence and of its role in human melanin formation . Science 112:223-225, 1950.Crossref 14. Saunders T: Clear cell acanthoma . Read before the American Dermatological Association, Scottsdale, Ariz, 1969 . 15. Wells GC, Wilson-Jones E: Degos' acanthoma (acanthome a cellules claires): A report of five cases with particular reference to the histochemistry . Brit J Derm 79:249-258, 1967.Crossref 16. Vandersteen PR: The Ichthyosiform Dermatoses: A Clinical, Genetic, Enzyme Histochemical, and Ultrastructural Study, thesis. University of Minnesota, Rochester, 1970. 17. Dimitrova J: Acanthoma clarocellulare . Derm Venerol 5:193-197, 1966. 18. Abulafia J, Grinspan D, Casas JG, et al: Acantoma de celulas claras . Arch Argent Derm 16:278-289, 1966. 19. Wilson-Jones E, Wells GC: Degos' acanthoma (acanthome a cellules claires) . Arch Derm 94:286-294, 1966.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1972

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