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Methotrexate-Induced Carcinoma?

Methotrexate-Induced Carcinoma? Abstract Posterior nasopharyngeal carcinoma associated with a high antibody titer to Epstein-Barr virus occurred in a 45-year-old man who had been receiving methotrexate therapy for psoriasis. Although this single case report does not establish methotrexate as a carcinogen in a class with arsenic, the action of immunosuppressive drugs in the body and the increased possibility that some cancers are virus-induced should alert others to be watchful for similar cases. References 1. Rosenberg EW, Yusk JW: Molluscum contangiosum: Eruption following treatment with prednisone and methotrexate . Arch Derm 101:439-441, 1970.Crossref 2. Allison J: Methotrexate and smallpox vaccination . Lancet 2:1250, 1968.Crossref 3. Keast D: Immunosurveillance and cancer . Lancet 2:710-712, 1970.Crossref 4. Henle G, Henle W, Clifford P, et al: Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups . J Nat Cancer Inst 43:1147-1157, 1969. 5. Henle W, Henle G, Hung-Chu H: Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasm and controlled groups . J Nat Cancer Inst 44:225-231, 1970. 6. Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Co, 1970. 7. von Tongeran JHN, Kunst A, Majoor CLH: Folic acid deficiency in chronic arsenic poisoning . Lancet 1:784-786, 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Methotrexate-Induced Carcinoma?

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1971 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1971.04000170039009
Publisher site
See Article on Publisher Site

Abstract

Abstract Posterior nasopharyngeal carcinoma associated with a high antibody titer to Epstein-Barr virus occurred in a 45-year-old man who had been receiving methotrexate therapy for psoriasis. Although this single case report does not establish methotrexate as a carcinogen in a class with arsenic, the action of immunosuppressive drugs in the body and the increased possibility that some cancers are virus-induced should alert others to be watchful for similar cases. References 1. Rosenberg EW, Yusk JW: Molluscum contangiosum: Eruption following treatment with prednisone and methotrexate . Arch Derm 101:439-441, 1970.Crossref 2. Allison J: Methotrexate and smallpox vaccination . Lancet 2:1250, 1968.Crossref 3. Keast D: Immunosurveillance and cancer . Lancet 2:710-712, 1970.Crossref 4. Henle G, Henle W, Clifford P, et al: Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups . J Nat Cancer Inst 43:1147-1157, 1969. 5. Henle W, Henle G, Hung-Chu H: Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasm and controlled groups . J Nat Cancer Inst 44:225-231, 1970. 6. Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Co, 1970. 7. von Tongeran JHN, Kunst A, Majoor CLH: Folic acid deficiency in chronic arsenic poisoning . Lancet 1:784-786, 1965.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1971

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