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PSORIASIS

PSORIASIS Abstract To the Editor.— In regard to the report by Leavell and Yarbro of "Hydroxyurea: A New Treatment for Psoriasis" (Arch Derm 102:144-150, 1970), I was disappointed that they did not make specific reference to some of the studies of other cytotoxic agents in the treatment of psoriasis. Purine analogues,1-3 alkylating agents2,3 and other antimetabolites4 have been reported to be effective in psoriasis. Thus, the question is whether hydroxyurea has a better therapeutic index and less side effects in the treatment of psoriasis compared with these other cytotoxic drugs. A comparison study would be of interest. I share the feeling of the authors that there may be better, safer drugs than methotrexate in severe psoriasis. References 1. Demis DJ, Brown CS, Crosby WH: Thioguanine in the treatment of certain autoimmune, immunologic and related diseases . Amer J Med 37: 195, 1964.Crossref 2. Epstein WL, Maibach HI: Immunologic competence of patients with psoriasis receiving cytotoxic therapy . Arch Derm 91:599, 1965.Crossref 3. Higgins LC Jr, Thompson JG: Psoriasis with arthritis: Chemotherapy with cyclophosphamide, nitrogen mustard and 6-mercaptopurine . Southern Med J 59:1191, 1966.Crossref 4. Calabresi P, Turner RW: Beneficial effects of triacetyl azauridine in psoriasis and mycosis fungoides . Ann Intern Med 64:352, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

PSORIASIS

Omura, George A.
Archives of Dermatology , Volume 102 (6) – Dec 1, 1970
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PSORIASIS

Abstract

Abstract To the Editor.— In regard to the report by Leavell and Yarbro of "Hydroxyurea: A New Treatment for Psoriasis" (Arch Derm 102:144-150, 1970), I was disappointed that they did not make specific reference to some of the studies of other cytotoxic agents in the treatment of psoriasis. Purine analogues,1-3 alkylating agents2,3 and other antimetabolites4 have been reported to be effective in psoriasis. Thus, the question is whether hydroxyurea has a better therapeutic index...
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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1970.04000120112022
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— In regard to the report by Leavell and Yarbro of "Hydroxyurea: A New Treatment for Psoriasis" (Arch Derm 102:144-150, 1970), I was disappointed that they did not make specific reference to some of the studies of other cytotoxic agents in the treatment of psoriasis. Purine analogues,1-3 alkylating agents2,3 and other antimetabolites4 have been reported to be effective in psoriasis. Thus, the question is whether hydroxyurea has a better therapeutic index and less side effects in the treatment of psoriasis compared with these other cytotoxic drugs. A comparison study would be of interest. I share the feeling of the authors that there may be better, safer drugs than methotrexate in severe psoriasis. References 1. Demis DJ, Brown CS, Crosby WH: Thioguanine in the treatment of certain autoimmune, immunologic and related diseases . Amer J Med 37: 195, 1964.Crossref 2. Epstein WL, Maibach HI: Immunologic competence of patients with psoriasis receiving cytotoxic therapy . Arch Derm 91:599, 1965.Crossref 3. Higgins LC Jr, Thompson JG: Psoriasis with arthritis: Chemotherapy with cyclophosphamide, nitrogen mustard and 6-mercaptopurine . Southern Med J 59:1191, 1966.Crossref 4. Calabresi P, Turner RW: Beneficial effects of triacetyl azauridine in psoriasis and mycosis fungoides . Ann Intern Med 64:352, 1966.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Dec 1, 1970

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