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Congenital Bullous Ichthyosiform Erythroderma: Epidermolytic Hyperkeratosis—Treatment With Methotrexate

Congenital Bullous Ichthyosiform Erythroderma: Epidermolytic Hyperkeratosis—Treatment With... Abstract In contrast to recently reported successful methotrexate therapy of congenital bullous ichthyosiform erythroderma (CBIE), two cases failed to respond to the dosages of methotrexate normally used in psoriasis. Thiamiprine was also without effect. This was despite the demonstration of markedly increased epidermal turnover in these patients using tritiated thymidine autoradiography. We suspect the failure to respond is because the increased epidermal cell turnover in this disease is a secondary phenomenon involving mechanisms not responsive to antimetabolites. References 1. Brocq IL: Erythrodermie congenitale ichthyosiforme avec hyperepidermotrophie . Ann Derm Syph 3:1-31, 1902. 2. Wells RS: Ichthyosis . Brit Med J 2:1504-1506, 1966.Crossref 3. Frost P, Van Scott EJ: Ichthyosiform dermatoses . Arch Derm 94:113-126, 1966.Crossref 4. Frost P, Weinstein GD, Van Scott EJ: The ichthyosiform dermatoses: II. Autoradiographic studies of epidermal proliferation . J Invest Derm 47:561-567, 1966.Crossref 5. Weinstein GD, Van Scott EJ: Autoradiographic analyses of turnover times of normal and psoriatic epidermis . J Invest Derm 45:257-262, 1965.Crossref 6. Epstein WL, Maibach HI: Cell renewal in human epidermis . Arch Derm 92:462-468, 1965.Crossref 7. Fisher LB, Wells GC: The mitotic rate and duration in lesions of psoriasis and ichthyosis . Brit J Derm 80:235, 1968.Crossref 8. Esterly NB, Maxwell E: Non-bullous congenital ichthyosiform erythroderma . Pediatrics 41:120-129, 1968. 9. Esterly NB: The ichthyosiform dermatoses . Pediatrics 42:990-1004, 1968. 10. Reed RJ, Galvanek EG, Lubritz RR: Bullous congenital ichthyosiform hyperkeratosis . Arch Derm 89:665-674, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Congenital Bullous Ichthyosiform Erythroderma: Epidermolytic Hyperkeratosis—Treatment With Methotrexate

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1970.04000050032005
Publisher site
See Article on Publisher Site

Abstract

Abstract In contrast to recently reported successful methotrexate therapy of congenital bullous ichthyosiform erythroderma (CBIE), two cases failed to respond to the dosages of methotrexate normally used in psoriasis. Thiamiprine was also without effect. This was despite the demonstration of markedly increased epidermal turnover in these patients using tritiated thymidine autoradiography. We suspect the failure to respond is because the increased epidermal cell turnover in this disease is a secondary phenomenon involving mechanisms not responsive to antimetabolites. References 1. Brocq IL: Erythrodermie congenitale ichthyosiforme avec hyperepidermotrophie . Ann Derm Syph 3:1-31, 1902. 2. Wells RS: Ichthyosis . Brit Med J 2:1504-1506, 1966.Crossref 3. Frost P, Van Scott EJ: Ichthyosiform dermatoses . Arch Derm 94:113-126, 1966.Crossref 4. Frost P, Weinstein GD, Van Scott EJ: The ichthyosiform dermatoses: II. Autoradiographic studies of epidermal proliferation . J Invest Derm 47:561-567, 1966.Crossref 5. Weinstein GD, Van Scott EJ: Autoradiographic analyses of turnover times of normal and psoriatic epidermis . J Invest Derm 45:257-262, 1965.Crossref 6. Epstein WL, Maibach HI: Cell renewal in human epidermis . Arch Derm 92:462-468, 1965.Crossref 7. Fisher LB, Wells GC: The mitotic rate and duration in lesions of psoriasis and ichthyosis . Brit J Derm 80:235, 1968.Crossref 8. Esterly NB, Maxwell E: Non-bullous congenital ichthyosiform erythroderma . Pediatrics 41:120-129, 1968. 9. Esterly NB: The ichthyosiform dermatoses . Pediatrics 42:990-1004, 1968. 10. Reed RJ, Galvanek EG, Lubritz RR: Bullous congenital ichthyosiform hyperkeratosis . Arch Derm 89:665-674, 1964.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1970

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