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Cutaneous Eruptions and in Vitro Lymphocyte Hypersensitivity: Associated With Oral Contraceptives and Mestranol

Cutaneous Eruptions and in Vitro Lymphocyte Hypersensitivity: Associated With Oral Contraceptives... Abstract Two patients who developed cutaneous reactions while taking contraceptive hormones are described. In both of these patients the addition of mestranol to in vitro cultures of their peripheral blood lymphocytes resulted in stimulation of lymphoblast formation as measured by the uptake of tritiated thymidine. The eruptions in these cases may represent instances of hypersensitivity to estrogenic components of contraceptive pills. References 1. James DG: Erythema nodosum . Brit Med J 1:843-857, 1961.Crossref 2. Holcomb FD: Erythema nodosum associated with use of oral contraceptives: Report of a case . Obstet Gynec 25:156-157, 1965. 3. Matz M: Letter to the editor . New Eng J Med 276:351-352, 1967.Crossref 4. Baden HP, Holcomb FD: Erythema nodosum from oral contraceptives . Arch Derm 98:634-635, 1968.Crossref 5. Savel H: Effect of human tumor extracts upon autologous peripheral blood lymphocytes . Cancer 24:56-63, 1969.Crossref 6. Hartog M, Cline MJ, Grodskiy GM: The response of human leucocyte cultures to stimulation by tuberculin and phytohemagglutinin measured by the uptake of radioactive thymidine . Clin Exp Immun 2:217-228, 1967. 7. Mills JA: The immunologic significance of antigen induced lymphocytes transformation in vitro . J Immun 97:239-247, 1966. 8. Holland P, Mauer AM: Drug-induced in vitro stimulation of lymphocyte . Lancet 1:1368-1369, 1964.Crossref 9. Sarkany I: Lymphocyte transformation in drug hypersensitivity . Lancet 1:743-745, 1967.Crossref 10. Halpern B, Ky NT, Amache N: Diagnosis of drug allergy in vitro with the lymphocyte transformation test . J Allerg 40:168-181, 1967.Crossref 11. Levene G, Baker H: Drug reactions: II. Lymphocyte transformation in vitro and drug hypersensitivity . Brit J Derm 80:415-417, 1968.Crossref 12. Schleicher EM: L.E. cells after oral contraceptives . Lancet 1:821-822, 1968.Crossref 13. Bole GG Jr, Friedlaender MH, Smith CK: Rheumatic symptoms and serological abnormalities induced by oral contraceptives . Lancet 1:323-326, 1969.Crossref 14. Laragh JH, Sealey JE, Ledingham JGG, et al: Oral contraceptives: Renin, aldosterone and high blood pressure . JAMA 201:918-922, 1967.Crossref 15. Newton MA, Sealey JE, Ledingham JGG, et al: High blood pressure and oral contraceptives: Changes in plasma renin and renin substrate and in aldosterone excretion . Amer J Obstet and Gynec 101:1037-1045, 1968. 16. Erickson LR, Peterka ES: Sunlight sensitivity from oral contraceptives . JAMA 203:980-981, 1968.Crossref 17. Urban E, Frank BW, Kern F Jr: Liver dysfunction with mestranol but not with horethynodrel in a patient with Enovid-induced jaundice . Ann Intern Med 68:598-602, 1968.Crossref 18. Oppenheim JJ: Relationship of in vitro lymphocyte transformation to delayed hypersensitivity in guinea pigs and man . Fed Proc 27:21-28, 1968. 19. Assem ESK, Schild HO: Detection of allergy to penicillin and other antigens by in vitro passive sensitization and histamine release from human and monkey lung . Brit Med J 3:272-276, 1968.Crossref 20. Søborg M, Bendixen G: Human lymphocyte migration as a parameter of hypersensitivity . Acta Med Scand 181:247-256, 1967.Crossref 21. Sarkany I: Clinical and laboratory aspects of drug allergy . Proc Roy Soc Med 61:891-894, 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cutaneous Eruptions and in Vitro Lymphocyte Hypersensitivity: Associated With Oral Contraceptives and Mestranol

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1970.04000020057009
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Abstract

Abstract Two patients who developed cutaneous reactions while taking contraceptive hormones are described. In both of these patients the addition of mestranol to in vitro cultures of their peripheral blood lymphocytes resulted in stimulation of lymphoblast formation as measured by the uptake of tritiated thymidine. The eruptions in these cases may represent instances of hypersensitivity to estrogenic components of contraceptive pills. References 1. James DG: Erythema nodosum . Brit Med J 1:843-857, 1961.Crossref 2. Holcomb FD: Erythema nodosum associated with use of oral contraceptives: Report of a case . Obstet Gynec 25:156-157, 1965. 3. Matz M: Letter to the editor . New Eng J Med 276:351-352, 1967.Crossref 4. Baden HP, Holcomb FD: Erythema nodosum from oral contraceptives . Arch Derm 98:634-635, 1968.Crossref 5. Savel H: Effect of human tumor extracts upon autologous peripheral blood lymphocytes . Cancer 24:56-63, 1969.Crossref 6. Hartog M, Cline MJ, Grodskiy GM: The response of human leucocyte cultures to stimulation by tuberculin and phytohemagglutinin measured by the uptake of radioactive thymidine . Clin Exp Immun 2:217-228, 1967. 7. Mills JA: The immunologic significance of antigen induced lymphocytes transformation in vitro . J Immun 97:239-247, 1966. 8. Holland P, Mauer AM: Drug-induced in vitro stimulation of lymphocyte . Lancet 1:1368-1369, 1964.Crossref 9. Sarkany I: Lymphocyte transformation in drug hypersensitivity . Lancet 1:743-745, 1967.Crossref 10. Halpern B, Ky NT, Amache N: Diagnosis of drug allergy in vitro with the lymphocyte transformation test . J Allerg 40:168-181, 1967.Crossref 11. Levene G, Baker H: Drug reactions: II. Lymphocyte transformation in vitro and drug hypersensitivity . Brit J Derm 80:415-417, 1968.Crossref 12. Schleicher EM: L.E. cells after oral contraceptives . Lancet 1:821-822, 1968.Crossref 13. Bole GG Jr, Friedlaender MH, Smith CK: Rheumatic symptoms and serological abnormalities induced by oral contraceptives . Lancet 1:323-326, 1969.Crossref 14. Laragh JH, Sealey JE, Ledingham JGG, et al: Oral contraceptives: Renin, aldosterone and high blood pressure . JAMA 201:918-922, 1967.Crossref 15. Newton MA, Sealey JE, Ledingham JGG, et al: High blood pressure and oral contraceptives: Changes in plasma renin and renin substrate and in aldosterone excretion . Amer J Obstet and Gynec 101:1037-1045, 1968. 16. Erickson LR, Peterka ES: Sunlight sensitivity from oral contraceptives . JAMA 203:980-981, 1968.Crossref 17. Urban E, Frank BW, Kern F Jr: Liver dysfunction with mestranol but not with horethynodrel in a patient with Enovid-induced jaundice . Ann Intern Med 68:598-602, 1968.Crossref 18. Oppenheim JJ: Relationship of in vitro lymphocyte transformation to delayed hypersensitivity in guinea pigs and man . Fed Proc 27:21-28, 1968. 19. Assem ESK, Schild HO: Detection of allergy to penicillin and other antigens by in vitro passive sensitization and histamine release from human and monkey lung . Brit Med J 3:272-276, 1968.Crossref 20. Søborg M, Bendixen G: Human lymphocyte migration as a parameter of hypersensitivity . Acta Med Scand 181:247-256, 1967.Crossref 21. Sarkany I: Clinical and laboratory aspects of drug allergy . Proc Roy Soc Med 61:891-894, 1968.

Journal

Archives of Dermatology – American Medical Association

Published: Feb 1, 1970

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