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Skin and Hair Regeneration After Calciphylaxis: Histologic Changes During Formation and Shedding of the Calciphylactic Carapace of the Rat

Skin and Hair Regeneration After Calciphylaxis: Histologic Changes During Formation and Shedding... Abstract Detailed histologic analysis of the stages of localized calciphylaxis in rat skin suggests that the calcified carapace does not contain the complete skin and that sufficient connective tissue and epithelium remains behind to serve as a source of regeneration. The regenerate is incomplete and has many features of scar tissue. Elastic fibers are not restored. The number of hairs is greatly diminished. It could not be ascertained whether all of the hairs growing later come from surviving hair roots, or if true neogenesis plays a part. Other details of interest are the greatly increased amount of calcium in growing hairs and the absence of alcian blue stainable substances in mast cell granules following calciphylaxis. References 1. Selye, H.: Calciphylaxis , Chicago: University of Chicago Press, 1962. 2. Butcher, O.: Restitutive Growth in the Hair Follicle of the Rat , Ann NY Acad Sci 83:369-377 ( (Nov) ) 1959.Crossref 3. Billingham, R.E.; Mangold, R.; and Silvers, W.K.: The Neogenesis of Skin in Antlers of Deer , Ann NY Acad Sci 83:491-497 ( (Nov) ) 1959.Crossref 4. Kligman, A.M.: Neogenesis in Human Hair Follicles , Ann NY Acad Sci 83:507-511 ( (Nov) ) 1959.Crossref 5. Schoenfeld, R.J.: Production of Hairless Skin in Rats , J Invest Derm 34:1 ( (Jan) ) 1960. 6. Mikhail, G.R.: Hair Neogenesis in Rat Skin , Arch Derm 88:713-728 ( (Dec) ) 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Skin and Hair Regeneration After Calciphylaxis: Histologic Changes During Formation and Shedding of the Calciphylactic Carapace of the Rat

Kelly, Edward W.; Milkintas, Jadvyga
Archives of Dermatology , Volume 100 (2) – Aug 1, 1969
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1969.01610260106020
Publisher site
See Article on Publisher Site

Abstract

Abstract Detailed histologic analysis of the stages of localized calciphylaxis in rat skin suggests that the calcified carapace does not contain the complete skin and that sufficient connective tissue and epithelium remains behind to serve as a source of regeneration. The regenerate is incomplete and has many features of scar tissue. Elastic fibers are not restored. The number of hairs is greatly diminished. It could not be ascertained whether all of the hairs growing later come from surviving hair roots, or if true neogenesis plays a part. Other details of interest are the greatly increased amount of calcium in growing hairs and the absence of alcian blue stainable substances in mast cell granules following calciphylaxis. References 1. Selye, H.: Calciphylaxis , Chicago: University of Chicago Press, 1962. 2. Butcher, O.: Restitutive Growth in the Hair Follicle of the Rat , Ann NY Acad Sci 83:369-377 ( (Nov) ) 1959.Crossref 3. Billingham, R.E.; Mangold, R.; and Silvers, W.K.: The Neogenesis of Skin in Antlers of Deer , Ann NY Acad Sci 83:491-497 ( (Nov) ) 1959.Crossref 4. Kligman, A.M.: Neogenesis in Human Hair Follicles , Ann NY Acad Sci 83:507-511 ( (Nov) ) 1959.Crossref 5. Schoenfeld, R.J.: Production of Hairless Skin in Rats , J Invest Derm 34:1 ( (Jan) ) 1960. 6. Mikhail, G.R.: Hair Neogenesis in Rat Skin , Arch Derm 88:713-728 ( (Dec) ) 1963.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Aug 1, 1969

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