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Penicillamine for Scleroderma

Penicillamine for Scleroderma Abstract Five patients with advanced systemic scleroderma were treated with high doses of D-penicillamine for periods up to 11 months. Careful measurement of mobility of involved joints before and after therapy revealed no improvement. Side effects occurred in all patients. References 1. Nimni, M., and Bavetta, L.: Collagen Defect Induced by Penicillamine , Science 150:905-907 ( (Nov) ) 1965.Crossref 2. Bensusan, H.: Lathyrism , Science 153:322-323 ( (July) ) 1966.Crossref 3. Harris, E., Jr.; Jaffe, I.; and Sjoerdsma, A.: Effect of Penicillamine on Collagen in Man , Arthritis and Rheum 9:509 ( (June) ) 1966. 4. Harris, E., Jr., and Sjoerdsma, A.: Effect of Penicillamine on Human Collagen and its Possible Application to Treatment of Scleroderma , Lancet 2:996-999 ( (Nov) ) 1966.Crossref 5. Daniels, L.; Williams, M.; and Worthingham, C.: Muscle Testing: Techniques of Manual Examination , Philadelphia: W. B. Saunders Co., 1956. 6. Rosenberg, L., and Hayslett, J.: Nephrotoxic Effects of Penicillamine in Cystinuria , JAMA 201:698-699 ( (Aug) ) 1967.Crossref 7. Sternlieb, I., and Scheinberg, I.: Penicillamine Therapy for Hepatolenticular Degeneration , JAMA 189:748-754 ( (Sept) ) 1964.Crossref 8. Henkin, R., et al: Decreased Taste Sensitivity After D-penicillamine Reversed by Copper Administration , Lancet 2:1268-1271 ( (Dec) ) 1967.Crossref 9. Keiser, H., et al: Loss of Taste During Therapy With Penicillamine , JAMA 203:381-383 ( (Feb) ) 1968.Crossref 10. Katz, R.: Penicillamine-Induced Skin Lesions , Arch Derm 95:196-198 ( (Feb) ) 1967.Crossref 11. Walshe, J.: Penicillamine , Practitioner 191:789-795 ( (Dec) ) 1963. 12. Penicillamine, The Medical Letter 9:51-52 ( (June) ) 1967. 13. Keiser, H., and Sjoerdsma, A.: Studies on β-aminopropionitrile in Patients With Scleroderma , Clin Pharmacol Therap 8:593-602 ( (July) -Aug) 1967. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Penicillamine for Scleroderma

Archives of Dermatology , Volume 98 (1) – Jul 1, 1968

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1968.01610130057012
Publisher site
See Article on Publisher Site

Abstract

Abstract Five patients with advanced systemic scleroderma were treated with high doses of D-penicillamine for periods up to 11 months. Careful measurement of mobility of involved joints before and after therapy revealed no improvement. Side effects occurred in all patients. References 1. Nimni, M., and Bavetta, L.: Collagen Defect Induced by Penicillamine , Science 150:905-907 ( (Nov) ) 1965.Crossref 2. Bensusan, H.: Lathyrism , Science 153:322-323 ( (July) ) 1966.Crossref 3. Harris, E., Jr.; Jaffe, I.; and Sjoerdsma, A.: Effect of Penicillamine on Collagen in Man , Arthritis and Rheum 9:509 ( (June) ) 1966. 4. Harris, E., Jr., and Sjoerdsma, A.: Effect of Penicillamine on Human Collagen and its Possible Application to Treatment of Scleroderma , Lancet 2:996-999 ( (Nov) ) 1966.Crossref 5. Daniels, L.; Williams, M.; and Worthingham, C.: Muscle Testing: Techniques of Manual Examination , Philadelphia: W. B. Saunders Co., 1956. 6. Rosenberg, L., and Hayslett, J.: Nephrotoxic Effects of Penicillamine in Cystinuria , JAMA 201:698-699 ( (Aug) ) 1967.Crossref 7. Sternlieb, I., and Scheinberg, I.: Penicillamine Therapy for Hepatolenticular Degeneration , JAMA 189:748-754 ( (Sept) ) 1964.Crossref 8. Henkin, R., et al: Decreased Taste Sensitivity After D-penicillamine Reversed by Copper Administration , Lancet 2:1268-1271 ( (Dec) ) 1967.Crossref 9. Keiser, H., et al: Loss of Taste During Therapy With Penicillamine , JAMA 203:381-383 ( (Feb) ) 1968.Crossref 10. Katz, R.: Penicillamine-Induced Skin Lesions , Arch Derm 95:196-198 ( (Feb) ) 1967.Crossref 11. Walshe, J.: Penicillamine , Practitioner 191:789-795 ( (Dec) ) 1963. 12. Penicillamine, The Medical Letter 9:51-52 ( (June) ) 1967. 13. Keiser, H., and Sjoerdsma, A.: Studies on β-aminopropionitrile in Patients With Scleroderma , Clin Pharmacol Therap 8:593-602 ( (July) -Aug) 1967.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1968

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