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Kyrle's Disease: II. Histopathologic Findings in Five Cases and Review of the Literature

Kyrle's Disease: II. Histopathologic Findings in Five Cases and Review of the Literature Abstract Histologic findings in five cases of Kyrle's disease are described. Diagnostic features are: (1) A keratotic plug filling an epithelial invagination; (2) parakeratosis in parts of the plug; (3) basophilic cellular debris (not staining with elastic tissue stains) within the plug; and (4) abnormal (parakeratotic) keratinization involving the entire thickness of the epidermis in at least one region of the plug resulting in contact between keratinized cells and dermis. Associated findings are: (1) Areas of acanthosis and thinning of epidermis surrounding the plug; (2) presence of varying numbers of neutrophils at the site of contact between keratinized cells and dermis; (3) a lymphocytic and histiocytic infiltrate about the lesion; and (4) a mild perivascular lymphocytic inflammatory infiltrate in the upper dermis. References 1. Kyrle, J.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans , Arch Derm Syph 123:466-493 ( (Aug) ) 1916.Crossref 2. Carter, V.H., and Constantine, V.S.: Kyrle's Disease: I. Clinical Findings in Five Cases and Review of the Literature , Arch Derm 97:624-632 ( (June) ) 1968.Crossref 3. Fried, A.: Über einen Fall von Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans , Arch Derm Syph 143:45-51 ( (April) ) 1923.Crossref 4. Bartos, A.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans (Kyrle) , Zbl Hertz Gefäss-Krankh 30:694, 1929. 5. Thyresson, N.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans , Acta Derm Venereal 31:287-289, 1951. 6. Prakken, J.R.: Kyrle's Disease , Acta Derm Venereal 34:360-367, 1954. 7. de Graciansky, P., et al: La Maladie de Kyrle , Ann Derm Syph 82:8-33 ( (Jan) -Feb) 1955. 8. Orbaneja, J., and Quinones, P.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans (Kyrle) , Actas Dermosif 6:237-247 ( (Jan) ) 1955. 9. Quiroga, M.I.; Cordero, A.A.; and Follmann, E.: Enfermedad de Kyrle , Acta Derm Venereal 36:167-175, 1956. 10. Abele, D., and Dobson, R.: Hyperkeratosis Penetrans (Kyrle's Disease) , Arch Derm 83:277-283 ( (Feb) ) 1961.Crossref 11. Peterson, W.; Goltz, R.; and Hult, A.: Hyperkeratosis Penetrans (Kyrle's Disease) , Arch Derm 88:210-214 ( (Aug) ) 1963.Crossref 12. Mescon, H.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans (Kyrle's Disease), society transactions , Arch Derm 89:769 ( (May) ) 1964. 13. Keuper, C.: A Case for Diagnosis: Kyrle's Disease? society transactions , Arch Derm 92:476 ( (Oct) ) 1965.Crossref 14. Hashimoto, K.: Personal communication regarding case in reference 13, 1967. 15. McManus, J.F.A., and Mowry, R.W.: Staining Methods Histologic and Histochemical , New York: Paul B. Hoeber, Inc., Medical Book Dept of Harper & Row, Publishers, Inc., 1960. 16. Mowry, R.W.: The Special Value of Methods That Color Both Acid and Vicinal Hydroxyl Groups in the Histochemical Study of Mucins , Ann NY Acad Sci 106:402, 1963.Crossref 17. Barrnett, R.J., and Seligman, A.M.: Histochemical Demonstration of Protein-Bound Sulfhydryl Groups , Science 116:323-327 ( (Sept) ) 1952.Crossref 18. Straus, J.S., and Kligman, A.M.: The Pathologic Dynamics of Acne Vulgaris , Arch Derm 82:779-790 ( (Nov) ) 1960.Crossref 19. Mehregan, A.H.; Schwartz, O.D.; and Livingood, C.S.: Reactive Perforating Collagenosis , Arch Derm 96:277-282 ( (Sept) ) 1967.Crossref 20. Montgomery, H.: Dermatopathology , New York: Paul B. Hoeber, Inc., Medical Book Dept of Harper and Row, Publishers, Inc., 1967. 21. Lever, W.F.: Histopathology of the Skin , Philadelphia: J. B. Lippincott Co., 1967. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Kyrle's Disease: II. Histopathologic Findings in Five Cases and Review of the Literature

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1968.01610120023003
Publisher site
See Article on Publisher Site

Abstract

Abstract Histologic findings in five cases of Kyrle's disease are described. Diagnostic features are: (1) A keratotic plug filling an epithelial invagination; (2) parakeratosis in parts of the plug; (3) basophilic cellular debris (not staining with elastic tissue stains) within the plug; and (4) abnormal (parakeratotic) keratinization involving the entire thickness of the epidermis in at least one region of the plug resulting in contact between keratinized cells and dermis. Associated findings are: (1) Areas of acanthosis and thinning of epidermis surrounding the plug; (2) presence of varying numbers of neutrophils at the site of contact between keratinized cells and dermis; (3) a lymphocytic and histiocytic infiltrate about the lesion; and (4) a mild perivascular lymphocytic inflammatory infiltrate in the upper dermis. References 1. Kyrle, J.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans , Arch Derm Syph 123:466-493 ( (Aug) ) 1916.Crossref 2. Carter, V.H., and Constantine, V.S.: Kyrle's Disease: I. Clinical Findings in Five Cases and Review of the Literature , Arch Derm 97:624-632 ( (June) ) 1968.Crossref 3. Fried, A.: Über einen Fall von Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans , Arch Derm Syph 143:45-51 ( (April) ) 1923.Crossref 4. Bartos, A.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans (Kyrle) , Zbl Hertz Gefäss-Krankh 30:694, 1929. 5. Thyresson, N.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans , Acta Derm Venereal 31:287-289, 1951. 6. Prakken, J.R.: Kyrle's Disease , Acta Derm Venereal 34:360-367, 1954. 7. de Graciansky, P., et al: La Maladie de Kyrle , Ann Derm Syph 82:8-33 ( (Jan) -Feb) 1955. 8. Orbaneja, J., and Quinones, P.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans (Kyrle) , Actas Dermosif 6:237-247 ( (Jan) ) 1955. 9. Quiroga, M.I.; Cordero, A.A.; and Follmann, E.: Enfermedad de Kyrle , Acta Derm Venereal 36:167-175, 1956. 10. Abele, D., and Dobson, R.: Hyperkeratosis Penetrans (Kyrle's Disease) , Arch Derm 83:277-283 ( (Feb) ) 1961.Crossref 11. Peterson, W.; Goltz, R.; and Hult, A.: Hyperkeratosis Penetrans (Kyrle's Disease) , Arch Derm 88:210-214 ( (Aug) ) 1963.Crossref 12. Mescon, H.: Hyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans (Kyrle's Disease), society transactions , Arch Derm 89:769 ( (May) ) 1964. 13. Keuper, C.: A Case for Diagnosis: Kyrle's Disease? society transactions , Arch Derm 92:476 ( (Oct) ) 1965.Crossref 14. Hashimoto, K.: Personal communication regarding case in reference 13, 1967. 15. McManus, J.F.A., and Mowry, R.W.: Staining Methods Histologic and Histochemical , New York: Paul B. Hoeber, Inc., Medical Book Dept of Harper & Row, Publishers, Inc., 1960. 16. Mowry, R.W.: The Special Value of Methods That Color Both Acid and Vicinal Hydroxyl Groups in the Histochemical Study of Mucins , Ann NY Acad Sci 106:402, 1963.Crossref 17. Barrnett, R.J., and Seligman, A.M.: Histochemical Demonstration of Protein-Bound Sulfhydryl Groups , Science 116:323-327 ( (Sept) ) 1952.Crossref 18. Straus, J.S., and Kligman, A.M.: The Pathologic Dynamics of Acne Vulgaris , Arch Derm 82:779-790 ( (Nov) ) 1960.Crossref 19. Mehregan, A.H.; Schwartz, O.D.; and Livingood, C.S.: Reactive Perforating Collagenosis , Arch Derm 96:277-282 ( (Sept) ) 1967.Crossref 20. Montgomery, H.: Dermatopathology , New York: Paul B. Hoeber, Inc., Medical Book Dept of Harper and Row, Publishers, Inc., 1967. 21. Lever, W.F.: Histopathology of the Skin , Philadelphia: J. B. Lippincott Co., 1967.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1968

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