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Some New Aspects of the Langerhans Cell

Some New Aspects of the Langerhans Cell Abstract Electron microscopic examination showed varying numbers of typical Langerhans cells in the dermis in normal human skin, pityriasis rosea, reticulum cell sarcoma, and Letterer-Siwe disease as well as among the stromal and parenchymal cells of several benign appendage tumors. Langerhans cells were observed crossing the basement membrane and an epidermal Langerhans cell in mitosis was seen. These findings suggest that Langerhans cells are not directly related to epidermal melanocytes and may constitute a self-perpetuating "intraepidermal phagocytic system" to which histiocytes from the dermis are added from time to time. References 1. Billingham, R.E., and Medawar, P.B.: A Study of the Branched Cells of the Mammalian Epidermis With Special Reference to the Fate of Their Division Products , Phil Trans Roy Soc (London, Series B) 237:151, 1953.Crossref 2. Masson, P.: Pigment Cells in Man , New York Acad Sci 4:15, 1948. 3. Breathnach, A.S., and Goodwin, E.P.: Electron Microscopy of Nonkeratinocytes in the Basal Layer of White Epidermis of the Recessively Spotted Guinea Pig , J Anat 99:377, 1965. 4. Zelickson, A.S.: The Langerhans Cells , J Invest Derm 44:201, 1965. 5. Wiedmann, A.: " Über die Struktur des neurovegetativen Systems , Hautarzt 15:13, 1964. 6. Breathnach, A.S.: A New Concept of the Relation Between the Langerhans Cell and the Melanocyte , J Invest Derm 40:279, 1963.Crossref 7. Mishima, Y.: Melanosomes in Phagocytic Vacuoles in Langerhans Cells , J Cell Biol 30:417, 1966.Crossref 8. Tarnowski, W.M., and Hashimoto, K.: Newly Recognized Mode of Intracellular Transport , Clin Res 15:255, 1967. 9. Hashimoto, K., and Tarnowski, W.M.: Ultrastructural Studies of Racket-Bodies in Epidermal Langerhans Cells and in Histiocytosis-X , Fed Proc 26:370, 1967. 10. Tarnowski, W.M., and Hashimoto, K.: Langerhans Cell Granules in Histiocytosis-X , Arch Derm 96:298, 1967.Crossref 11. Hashimoto, K., et al: Electron Miroscopic Studies of Oral Benign Leukoplakia , Oral Surg , to be published. 12. Hashimoto, K., et al: Eruptive Hidradenoma and Syringoma Histological, Histochemical and Electron Microscopic Studies , Arch Derm 96:500-519, 1967.Crossref 13. Campo-Aasen, I., and Pearse, A.G.E.: Enzymology of Cell of Langerhans , Med Cutanea 1:35, 1966. 14. Farquhar, M., and Palade, G.E.: Junctional Complexes in Various Epithelia , J Cell Biol 17:375, 1963.Crossref 15. Wolff, K., and Winkelmann, R.K.: Quantitative Studies on the Langerhans Cell Population of Guinea Pig Epidermis , J Invest Derm 48:504, 1967. 16. Wolff, K., and Winkelmann, R.K.: The Influence of Ultraviolet Light on the Langerhans Cell Population and Its Hydrolytic Enzymes in Guinea Pigs , J Invest Derm 48:531, 1967. 17. Bleehan, S.S., et al: Differential Effect of 4-Isopropylcathecol on Melanocytes and Langerhans Cells in Cutaneous Depigmentation , Clin Res 15:247, 1967. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Some New Aspects of the Langerhans Cell

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References (20)

Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1968.01610100090015
Publisher site
See Article on Publisher Site

Abstract

Abstract Electron microscopic examination showed varying numbers of typical Langerhans cells in the dermis in normal human skin, pityriasis rosea, reticulum cell sarcoma, and Letterer-Siwe disease as well as among the stromal and parenchymal cells of several benign appendage tumors. Langerhans cells were observed crossing the basement membrane and an epidermal Langerhans cell in mitosis was seen. These findings suggest that Langerhans cells are not directly related to epidermal melanocytes and may constitute a self-perpetuating "intraepidermal phagocytic system" to which histiocytes from the dermis are added from time to time. References 1. Billingham, R.E., and Medawar, P.B.: A Study of the Branched Cells of the Mammalian Epidermis With Special Reference to the Fate of Their Division Products , Phil Trans Roy Soc (London, Series B) 237:151, 1953.Crossref 2. Masson, P.: Pigment Cells in Man , New York Acad Sci 4:15, 1948. 3. Breathnach, A.S., and Goodwin, E.P.: Electron Microscopy of Nonkeratinocytes in the Basal Layer of White Epidermis of the Recessively Spotted Guinea Pig , J Anat 99:377, 1965. 4. Zelickson, A.S.: The Langerhans Cells , J Invest Derm 44:201, 1965. 5. Wiedmann, A.: " Über die Struktur des neurovegetativen Systems , Hautarzt 15:13, 1964. 6. Breathnach, A.S.: A New Concept of the Relation Between the Langerhans Cell and the Melanocyte , J Invest Derm 40:279, 1963.Crossref 7. Mishima, Y.: Melanosomes in Phagocytic Vacuoles in Langerhans Cells , J Cell Biol 30:417, 1966.Crossref 8. Tarnowski, W.M., and Hashimoto, K.: Newly Recognized Mode of Intracellular Transport , Clin Res 15:255, 1967. 9. Hashimoto, K., and Tarnowski, W.M.: Ultrastructural Studies of Racket-Bodies in Epidermal Langerhans Cells and in Histiocytosis-X , Fed Proc 26:370, 1967. 10. Tarnowski, W.M., and Hashimoto, K.: Langerhans Cell Granules in Histiocytosis-X , Arch Derm 96:298, 1967.Crossref 11. Hashimoto, K., et al: Electron Miroscopic Studies of Oral Benign Leukoplakia , Oral Surg , to be published. 12. Hashimoto, K., et al: Eruptive Hidradenoma and Syringoma Histological, Histochemical and Electron Microscopic Studies , Arch Derm 96:500-519, 1967.Crossref 13. Campo-Aasen, I., and Pearse, A.G.E.: Enzymology of Cell of Langerhans , Med Cutanea 1:35, 1966. 14. Farquhar, M., and Palade, G.E.: Junctional Complexes in Various Epithelia , J Cell Biol 17:375, 1963.Crossref 15. Wolff, K., and Winkelmann, R.K.: Quantitative Studies on the Langerhans Cell Population of Guinea Pig Epidermis , J Invest Derm 48:504, 1967. 16. Wolff, K., and Winkelmann, R.K.: The Influence of Ultraviolet Light on the Langerhans Cell Population and Its Hydrolytic Enzymes in Guinea Pigs , J Invest Derm 48:531, 1967. 17. Bleehan, S.S., et al: Differential Effect of 4-Isopropylcathecol on Melanocytes and Langerhans Cells in Cutaneous Depigmentation , Clin Res 15:247, 1967.

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1968

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