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The Pigmented Basal Cell Epithelioma

The Pigmented Basal Cell Epithelioma Abstract In an electron microscopic study of the pigmented basal cell epithelioma, the high degree of activity of the dendritic cell is pointed out. The melanocyte is increased in size and the nucleus is multilobed. The cell is richly dendritic, and is producing an abundance of melanosomes. The granules produced accumulate in the dendritic tips of the melanocytes and are not passed to any great extent to the neoplastic epithelial cells. Thus, most of the pigment within the tumor is found in the large dendritic cells. The symbiotic relationship of epidermal cells and melanocytes is stressed. References 1. Bloch, B.: Ueber Benigne, nicht Naevoide Melanoepitheliome der Haut nebst Bemerkungen über das Wesen and die Genese der Dendritenzellen , Arch Derm Syph 153:20, 1927.Crossref 2. Becker, S.W.: Pigmented Epitheliomas , Arch Derm 27:981, 1933.Crossref 3. Eller, J.J., and Anderson, N.P.: Basal Cell Epitheliomas With Excessive Pigment Formation , Arch Derm 27:277, 1933.Crossref 4. Smith, L.M.; Garrett, H.D.; and Hart, M.S.: Pigmented Basal Cell Epithelioma , Arch Derm 81:95, 1960.Crossref 5. Vilanova, J.; Agaude, J.P.; and Rueda, L.: Cytologic Aspect of Basal Cell Carcinoma , J Invest Derm 39:123, 1962.Crossref 6. Lever, W.F.: Histopathology of the Skin , ed 3, Philadelphia: J.B. Lippincott, Company, 1961. 7. Zelickson, A.S.: Goltz, R.W.: and Hartmann, J.F.: A Histologic and Electron Microscopic Study of a Pigmenting Basal Cell Epithelioma , J Invest Derm 36:299, 1961. 8. Zelickson, A.S. (ed.): Ultrastructure of Normal and Abnormal Skin , Philadelphia: Lea and Febiger, Publishers, 1967. 9. Mishima, Y., and Pinkus, H.: Benign Mixed Tumor of Melanocytes and Malpighian cells: Melanoacanthoma , Arch Derm 81:539, 1960.Crossref 10. Pinkus, H., et al: " The Symbiosis of Melanocytes and Human Epidermis Under Normal and Abnormal Conditions ," in Gordon, M., (ed.): Pigment Cell Biology , New York: Academic Press, Inc., 1959, p 127. 11. Montagna, W.: The Structure and Function of the Skin , New York: Academic Press, Inc., 1962. 12. Quevedo, W.C., Jr.: The Role of Melanocytes in Skin Carcinogenesis, Conference on Biology of Cutaneous Cancer , National Cancer Institute, Monograph No. 10, 1963. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

The Pigmented Basal Cell Epithelioma

Zelickson, Alvin S.
Archives of Dermatology , Volume 96 (5) – Nov 1, 1967
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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1967.01610050046005
Publisher site
See Article on Publisher Site

Abstract

Abstract In an electron microscopic study of the pigmented basal cell epithelioma, the high degree of activity of the dendritic cell is pointed out. The melanocyte is increased in size and the nucleus is multilobed. The cell is richly dendritic, and is producing an abundance of melanosomes. The granules produced accumulate in the dendritic tips of the melanocytes and are not passed to any great extent to the neoplastic epithelial cells. Thus, most of the pigment within the tumor is found in the large dendritic cells. The symbiotic relationship of epidermal cells and melanocytes is stressed. References 1. Bloch, B.: Ueber Benigne, nicht Naevoide Melanoepitheliome der Haut nebst Bemerkungen über das Wesen and die Genese der Dendritenzellen , Arch Derm Syph 153:20, 1927.Crossref 2. Becker, S.W.: Pigmented Epitheliomas , Arch Derm 27:981, 1933.Crossref 3. Eller, J.J., and Anderson, N.P.: Basal Cell Epitheliomas With Excessive Pigment Formation , Arch Derm 27:277, 1933.Crossref 4. Smith, L.M.; Garrett, H.D.; and Hart, M.S.: Pigmented Basal Cell Epithelioma , Arch Derm 81:95, 1960.Crossref 5. Vilanova, J.; Agaude, J.P.; and Rueda, L.: Cytologic Aspect of Basal Cell Carcinoma , J Invest Derm 39:123, 1962.Crossref 6. Lever, W.F.: Histopathology of the Skin , ed 3, Philadelphia: J.B. Lippincott, Company, 1961. 7. Zelickson, A.S.: Goltz, R.W.: and Hartmann, J.F.: A Histologic and Electron Microscopic Study of a Pigmenting Basal Cell Epithelioma , J Invest Derm 36:299, 1961. 8. Zelickson, A.S. (ed.): Ultrastructure of Normal and Abnormal Skin , Philadelphia: Lea and Febiger, Publishers, 1967. 9. Mishima, Y., and Pinkus, H.: Benign Mixed Tumor of Melanocytes and Malpighian cells: Melanoacanthoma , Arch Derm 81:539, 1960.Crossref 10. Pinkus, H., et al: " The Symbiosis of Melanocytes and Human Epidermis Under Normal and Abnormal Conditions ," in Gordon, M., (ed.): Pigment Cell Biology , New York: Academic Press, Inc., 1959, p 127. 11. Montagna, W.: The Structure and Function of the Skin , New York: Academic Press, Inc., 1962. 12. Quevedo, W.C., Jr.: The Role of Melanocytes in Skin Carcinogenesis, Conference on Biology of Cutaneous Cancer , National Cancer Institute, Monograph No. 10, 1963.

Journal

Archives of Dermatology – American Medical Association

Published: Nov 1, 1967

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