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Pseudoxanthomatous Rheumatoid Nodules

Pseudoxanthomatous Rheumatoid Nodules Abstract Two cases of patients with an unusual form of rheumatoid nodules closely resembling tendon xanthomas are reported. The disease process was mistakenly diagnosed by numerous physicians as xanthomatosis in one case and as gouty tophi in the second case. The differential diagnosis of rheumatoid nodules rests on clinical and laboratory findings plus histologic confirmation. Occasionally, the onset of nodule formation antedates the onset of arthritis, adding to diagnostic confusion. This is to be distinguished from the entity, pseudorheumatoid nodules, which has been proposed to explain those rare cases where clinically and pathologically typical nodules persist over many years without the development of associated signs of rheumatoid arthritis. The development of x-ray demonstrable "punched out" bony radiolucencies in association with subcutaneous rheumatoid nodules is stressed. References 1. Mikkelson, W.M.; Duff, I.F.; and Robinson, W.D.: Unusual Manifestations of Rheumatoid Nodules , J Mich Med Soc 54:292-297, 1955. 2. Neligan, A.R.: Rheumatoid Arthritis With a Large Number of Subcutaneous Fibrous Nodules , Brit Med J 2:1046-1047, 1935.Crossref 3. Mesara, B.W.; Brody, G.L.; and Oberman, H.A.: Pseudo-Rheumatoid Subcutaneous Nodules , Amer J Clin Path 45:684-691, 1966. 4. Orkin, M., et al: Study of Multicentric Reticulohistiocytosis , Arch Derm 89:640-653, 1964.Crossref 5. Collins, D.H.: The Subcutaneous Nodules of Rheumatoid Arthritis , J Path Bact 35:97-114, 1937.Crossref 6. Kersley, G.D.; Gibson, H.J.; and Desmarais, M.H.L.: Nodule Formation in Rheumatic Diseases , Ann Rheum Dis 5:141-152, 1946.Crossref 7. Bennett, G.A.; Zeller, J.W.; and Bauer, W.: Subcutaneous Nodules of Rheumatoid Arthritis and Rheumatic Fever , Arch Path 30:70-89, 1940. 8. Lever, W.F.: Histopathology of the Skin , ed 3, Philadelphia: J. B. Lippincott Co., 1961, p 143. 9. Lowney, E.D., and Simons, H.M.: Rheumatoid Nodules of the Skin , Arch Derm 88:853-857, 1963.Crossref 10. Schwartz, S., and Steinbrocker: Production of Rheumatic Subcutaneous Nodules , Amer Heart J 40:100-104, 1950.Crossref 11. Edstram, G.: Rheumatoid Arthritis and Trauma , Acta Med Scand 142:11-29, 1952.Crossref 12. Svorrasow, E.: Rheumatoid Arthritis and Occupation , Acta Med Scand 140:355-358, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Pseudoxanthomatous Rheumatoid Nodules

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1967.01600320012002
Publisher site
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Abstract

Abstract Two cases of patients with an unusual form of rheumatoid nodules closely resembling tendon xanthomas are reported. The disease process was mistakenly diagnosed by numerous physicians as xanthomatosis in one case and as gouty tophi in the second case. The differential diagnosis of rheumatoid nodules rests on clinical and laboratory findings plus histologic confirmation. Occasionally, the onset of nodule formation antedates the onset of arthritis, adding to diagnostic confusion. This is to be distinguished from the entity, pseudorheumatoid nodules, which has been proposed to explain those rare cases where clinically and pathologically typical nodules persist over many years without the development of associated signs of rheumatoid arthritis. The development of x-ray demonstrable "punched out" bony radiolucencies in association with subcutaneous rheumatoid nodules is stressed. References 1. Mikkelson, W.M.; Duff, I.F.; and Robinson, W.D.: Unusual Manifestations of Rheumatoid Nodules , J Mich Med Soc 54:292-297, 1955. 2. Neligan, A.R.: Rheumatoid Arthritis With a Large Number of Subcutaneous Fibrous Nodules , Brit Med J 2:1046-1047, 1935.Crossref 3. Mesara, B.W.; Brody, G.L.; and Oberman, H.A.: Pseudo-Rheumatoid Subcutaneous Nodules , Amer J Clin Path 45:684-691, 1966. 4. Orkin, M., et al: Study of Multicentric Reticulohistiocytosis , Arch Derm 89:640-653, 1964.Crossref 5. Collins, D.H.: The Subcutaneous Nodules of Rheumatoid Arthritis , J Path Bact 35:97-114, 1937.Crossref 6. Kersley, G.D.; Gibson, H.J.; and Desmarais, M.H.L.: Nodule Formation in Rheumatic Diseases , Ann Rheum Dis 5:141-152, 1946.Crossref 7. Bennett, G.A.; Zeller, J.W.; and Bauer, W.: Subcutaneous Nodules of Rheumatoid Arthritis and Rheumatic Fever , Arch Path 30:70-89, 1940. 8. Lever, W.F.: Histopathology of the Skin , ed 3, Philadelphia: J. B. Lippincott Co., 1961, p 143. 9. Lowney, E.D., and Simons, H.M.: Rheumatoid Nodules of the Skin , Arch Derm 88:853-857, 1963.Crossref 10. Schwartz, S., and Steinbrocker: Production of Rheumatic Subcutaneous Nodules , Amer Heart J 40:100-104, 1950.Crossref 11. Edstram, G.: Rheumatoid Arthritis and Trauma , Acta Med Scand 142:11-29, 1952.Crossref 12. Svorrasow, E.: Rheumatoid Arthritis and Occupation , Acta Med Scand 140:355-358, 1951.

Journal

Archives of Dermatology – American Medical Association

Published: Feb 1, 1967

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