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BIOLOGICAL FALSE-POSITIVE REACTIONS

BIOLOGICAL FALSE-POSITIVE REACTIONS This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor: In their recent article, Kwittken and Goldberg (Arch Derm93:177, 1966) considered their patient's weakly reactive venereal disease research laboratory test for syphilis (VDRL) and complement fixation tests to be biologic false-positive (BFP) reactions. This patient also had a positive Reiter protein complement fixation test, but the authors comment only that false-positive reactions can occur with this test. This is certainly true, but the diagnosis of BFP reaction must not be made unless the treponema pallidum immobilization (TPI) test or an equally specific test is negative and there is no historical or physical evidence of the presence of syphilis. The authors' failure to perform a TPI test in the 83-year-old patient is understandable, but their reasoning in making the diagnosis of BFP reaction is not. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

BIOLOGICAL FALSE-POSITIVE REACTIONS

Sigal, Cecil
Archives of Dermatology , Volume 93 (6) – Jun 1, 1966
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BIOLOGICAL FALSE-POSITIVE REACTIONS

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor: In their recent article, Kwittken and Goldberg (Arch Derm93:177, 1966) considered their patient's weakly reactive venereal disease research laboratory test for syphilis (VDRL) and complement fixation tests to be biologic false-positive (BFP) reactions. This patient also had a positive Reiter protein complement fixation test, but the...
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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1966.01600240152033
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor: In their recent article, Kwittken and Goldberg (Arch Derm93:177, 1966) considered their patient's weakly reactive venereal disease research laboratory test for syphilis (VDRL) and complement fixation tests to be biologic false-positive (BFP) reactions. This patient also had a positive Reiter protein complement fixation test, but the authors comment only that false-positive reactions can occur with this test. This is certainly true, but the diagnosis of BFP reaction must not be made unless the treponema pallidum immobilization (TPI) test or an equally specific test is negative and there is no historical or physical evidence of the presence of syphilis. The authors' failure to perform a TPI test in the 83-year-old patient is understandable, but their reasoning in making the diagnosis of BFP reaction is not.

Journal

Archives of Dermatology – American Medical Association

Published: Jun 1, 1966

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