Access the full text.
Sign up today, get DeepDyve free for 14 days.
B.B. Levine (1961)
Studies on the Mechanism of the Formation of the Penicillin Antigen III. The N-(D-γ-Benzylpenicilloyl) Group as an Antigenic Determinant Responsible for Hypersensitivity to Penicillin GJ Exp Med, 114
B. Levine (1960)
STUDIES ON THE MECHANISM OF THE FORMATION OF THE PENICILLIN ANTIGENThe Journal of Experimental Medicine, 112
Bernard Levine (1965)
THE NATURE OF THE ANTIGEN-ANTIBODY COMPLEXES WHICH INITIATE ANAPHYLACTIC REACTIONS. II. THE EFFECT OF MOLECULAR SIZE ON THE ABILITIES OF HOMOLOGOUS MULTIVALENT BENZYLPENICILLOYL HAPTENS TO EVOKE PCA AND PASSIVE ARTHUS REACTIONS IN THE GUINEA PIG.Journal of immunology, 94
B.B. Levine (1964)
Studies on the Immunological Mechanisms of Penicillin AllergyImmunology, 7
Abstract To the Editor: In the article "Recent Advances in the Understanding of the Penicillin Urticarias" byOtis F. Jillson and Paul S. Porter, which appeared in the issue of the Archives of Dermatology of August 1965 the statement is made: "One of these degradation products, penicillenic acid, is the antigenic determinant in most cases of penicillin hypersensitivity." Much experimental and clinical work has been done to detect the antigenic determinants of penicillin sensitivity in man and it appears important to bring to attention that it is the benzylpenicilloyl haptenic group which is the major antigenic determinant in most cases of penicillin sensitivity.1 The accompanying diagram illustrates the rearrangement of penicillin G to penicillenic acid and the combination of penicillenic acid with lysine-amino groups of proteins to form the benzylpenicilloyl-lysine-protein linkage. This is structurally quite different from the penicillenic acid-protein linkage also illustrated in the diagram which shows the formation References 1. Levine, B.B., and Ovary, Z.: Studies on the Mechanism of the Formation of the Penicillin Antigen III. The N-(D-γ-Benzylpenicilloyl) Group as an Antigenic Determinant Responsible for Hypersensitivity to Penicillin G , J Exp Med 114:875-904, 1961.Crossref 2. Levine, B.B.: The Nature of the Antigen-Antibody Complexes Which Initiate Anaphylactic Reactions II. The Effect of Molecular Size on the Abilities of Homologous Multivalent Benzylpenicilloyl Haptens to Evoke PCA and Passive Arthus Reactions in the Guinea Pig , J Immunol 94:121-131, 1965. 3. Levine, B.B.: Studies on the Immunological Mechanisms of Penicillin Allergy , Immunology 7:527-541, 1964. 4. Levine, B.B.: Studies on the Mechanism of the Formation of the Penicillin Antigen , J Exp Med 112:1131-1154 ( (Dec) ) 1960.Crossref
Archives of Dermatology – American Medical Association
Published: May 1, 1966
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.