Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

ANTIGENIC DETERMINANTS IN PENICILLIN SENSITIVITY

ANTIGENIC DETERMINANTS IN PENICILLIN SENSITIVITY Abstract To the Editor: In the article "Recent Advances in the Understanding of the Penicillin Urticarias" byOtis F. Jillson and Paul S. Porter, which appeared in the issue of the Archives of Dermatology of August 1965 the statement is made: "One of these degradation products, penicillenic acid, is the antigenic determinant in most cases of penicillin hypersensitivity." Much experimental and clinical work has been done to detect the antigenic determinants of penicillin sensitivity in man and it appears important to bring to attention that it is the benzylpenicilloyl haptenic group which is the major antigenic determinant in most cases of penicillin sensitivity.1 The accompanying diagram illustrates the rearrangement of penicillin G to penicillenic acid and the combination of penicillenic acid with lysine-amino groups of proteins to form the benzylpenicilloyl-lysine-protein linkage. This is structurally quite different from the penicillenic acid-protein linkage also illustrated in the diagram which shows the formation References 1. Levine, B.B., and Ovary, Z.: Studies on the Mechanism of the Formation of the Penicillin Antigen III. The N-(D-γ-Benzylpenicilloyl) Group as an Antigenic Determinant Responsible for Hypersensitivity to Penicillin G , J Exp Med 114:875-904, 1961.Crossref 2. Levine, B.B.: The Nature of the Antigen-Antibody Complexes Which Initiate Anaphylactic Reactions II. The Effect of Molecular Size on the Abilities of Homologous Multivalent Benzylpenicilloyl Haptens to Evoke PCA and Passive Arthus Reactions in the Guinea Pig , J Immunol 94:121-131, 1965. 3. Levine, B.B.: Studies on the Immunological Mechanisms of Penicillin Allergy , Immunology 7:527-541, 1964. 4. Levine, B.B.: Studies on the Mechanism of the Formation of the Penicillin Antigen , J Exp Med 112:1131-1154 ( (Dec) ) 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

ANTIGENIC DETERMINANTS IN PENICILLIN SENSITIVITY

Archives of Dermatology , Volume 93 (5) – May 1, 1966

Loading next page...
 
/lp/american-medical-association/antigenic-determinants-in-penicillin-sensitivity-NvDKRy28Wf

References (4)

Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1966.01600230139042
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor: In the article "Recent Advances in the Understanding of the Penicillin Urticarias" byOtis F. Jillson and Paul S. Porter, which appeared in the issue of the Archives of Dermatology of August 1965 the statement is made: "One of these degradation products, penicillenic acid, is the antigenic determinant in most cases of penicillin hypersensitivity." Much experimental and clinical work has been done to detect the antigenic determinants of penicillin sensitivity in man and it appears important to bring to attention that it is the benzylpenicilloyl haptenic group which is the major antigenic determinant in most cases of penicillin sensitivity.1 The accompanying diagram illustrates the rearrangement of penicillin G to penicillenic acid and the combination of penicillenic acid with lysine-amino groups of proteins to form the benzylpenicilloyl-lysine-protein linkage. This is structurally quite different from the penicillenic acid-protein linkage also illustrated in the diagram which shows the formation References 1. Levine, B.B., and Ovary, Z.: Studies on the Mechanism of the Formation of the Penicillin Antigen III. The N-(D-γ-Benzylpenicilloyl) Group as an Antigenic Determinant Responsible for Hypersensitivity to Penicillin G , J Exp Med 114:875-904, 1961.Crossref 2. Levine, B.B.: The Nature of the Antigen-Antibody Complexes Which Initiate Anaphylactic Reactions II. The Effect of Molecular Size on the Abilities of Homologous Multivalent Benzylpenicilloyl Haptens to Evoke PCA and Passive Arthus Reactions in the Guinea Pig , J Immunol 94:121-131, 1965. 3. Levine, B.B.: Studies on the Immunological Mechanisms of Penicillin Allergy , Immunology 7:527-541, 1964. 4. Levine, B.B.: Studies on the Mechanism of the Formation of the Penicillin Antigen , J Exp Med 112:1131-1154 ( (Dec) ) 1960.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1966

There are no references for this article.