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A. Vial, W. Callahan (1957)
The effect of some tagged antibodies on human melanoblastomaCancer, 10
A. Woods, M. Little (1933)
UVEAL PIGMENT: HYPERSENSITIVITY AND THERAPEUSISArchives of Ophthalmology, 9
J. Riggs, P. Loh, Warren Eveland (1960)
A Simple Fractionation Method for Preparation of Fluorescein-labeled Gamma Globulin.∗Proceedings of the Society for Experimental Biology and Medicine, 105
R. L. Sutton (1916)
Unusual Variety of Vitiligo (Leucoderma Acquisitum Centrifugum)J Cut Dis, 34
A. L.: " Lorincz (1954)
Physiology and Biochemistry of Skin
A. Lerner, T. Fitzpatrick (1953)
The Control of Melanogenesis in Human Pigment Cells
B. McGuinness (1963)
MELANOCYTE‐STIMULATING HORMONE: A CLINICAL AND LABORATORY STUDYAnnals of the New York Academy of Sciences, 100
H. Levy, H. Sober (1960)
A Simple Chromatographic Method for Preparation of Gamma Globulin.∗Proceedings of the Society for Experimental Biology and Medicine, 103
R. Owen, C. Markert (1955)
Effects of antisera on tyrosinase in glomerella extracts.Journal of immunology, 74 4
H. Z.: " Lund (1960)
Proceedings of Fourth National Cancer Conference
Allen Ep (1955)
Malignant melanoma; spontaneous regression after pregnancy.BMJ, 2
J. Bunch (1918)
Vitiligo Patches with Central Pigmented Mole. 1Journal of the Royal Society of Medicine, 11
L. Goldman (1961)
Cancer ImmunologyArch Derm, 84
S. Becker, M. Spencer (1962)
Evaluation of monobenzone.JAMA, 180
T. Dasgupta, L. Bowden, J. Berg (1963)
MALIGNANT MELANOMA OF UNKNOWN PRIMARY ORIGIN.Surgery, gynecology & obstetrics, 117
G. H. Findlay (1957)
Histology of Sutton's NevusBrit J Derm, 69
H. Pinkus (1959)
Vitiligo; what is it.The Journal of investigative dermatology, 32 2, Part 2
O. Miura, T. Nakajima (1959)
[On a case of simultaneous distribution of depigmentation with parallel progression of malignant melanoma].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 10
H. Pinkus (1959)
Part V: Clinical Applications of Psoralens, and Related Materials: Vitiligo—What Is It?1Journal of Investigative Dermatology, 32
L. Shapiro
Leukoderm Acquisitum Centrifugum: Unusual CaseArch Derm
B. Cavell (1963)
Transplacental Metastasis of Malignant MelanomaActa Pædiatrica, 52
M. Leider, T. Cohen (1948)
Leukoderma acquisitum centrifugum.Archives of dermatology and syphilology, 57 3
F. P. Merklen (1949)
Maladie de Sutton à élèments multiples plus ou moins typiques avec taches achromiques circulaires sans centre naevique cliniquement apparentBull Soc Franc Derm Syph, 56
K. Kärcher (1960)
Systematisierte Depigmentierung bei strahlenbehandelten MelanomenDermatology, 120
H. Z. Lund (1962)
Melanotic Tumor of Skin
O. Stegmaier, S. Becker (1960)
Incidence of melanocytic nevi in young adults.The Journal of investigative dermatology, 34
N. Anderson (1954)
Moles, melanomas and epitheliomas in children.California medicine, 78 1
O. C. Stegmaier (1963)
Life Cycle of NevusMod Med, 31
T. Matuzawa , M. Watanabe, R. and Kondo (1953)
Case of Leucoderma in X-rayed Portion of Patient With MelanosarcomaShinshu Med J, 2
O. Miura (1959)
Über einen Fall von gleichzeitiger Ausbreitung von Depigmentierung mit parallelverlaufendem MelanomalignomHautarzt, 10
P. Masson (1951)
My conception of cellular neviCancer, 4
H. Tanaka (1958)
Studies on Pigmentation in Nevoid, Neoplastic, and Other Diseases of SkinJap J Derm, 68
H. Mason, E. Peterson, A. Frisch, ANDM. Karens (1954)
Melanoma chemotherapy I. Some properties of antimelanin gamma globulin.Cancer research, 14 9
M. Braitman (1958)
Junction nevus with spontaneous clinical disappearance.A.M.A. archives of dermatology, 77 6
(1963)
Autoimmune Diseases: Pathogenesis, Chemistry and TherapyMedical Journal of Australia, 2
T. Everson, W. Cole (1959)
SPONTANEOUS REGRESSION OF MALIGNANT DISEASE: GUEST EDITORIALJAMA, 169
A. Allen (1960)
Juvenile melanomas of children and adults and melanocarcinomas of children.Archives of dermatology, 82
J. H. Graham , N. A. Fogel, C. F. and Burgoon (1963)
Multiple Nonpigmented Nevi in Negro ChildArch Derm, 88
M. Ito (1952)
Malignant MelanomaTohoku J Exp Med, 55
G. L. Rohdenburg (1927)
Spontaneous Recession of Multiple Pigmented MolesArch Path Lab Med, 4
W. C. Sumner (1953)
Spontaneous Regression of Human MelanomaCancer, 6
F. P. Merklen (1949)
Cas type de maladie de Sutton vraie: Leucodermie centrifuge acquise geometriquement centree par un naevus pigmentaireBull Soc Franc Derm Syph, 56
R. Leszczynski (1926)
Über Suttonsche Krankheit (Leucoderma acquisitum centrifugum)Derm Wschr, 82
S. B. Frank (1964)
Halo NevusArch Derm, 89
S. Iijima, T. Kanazawa (1953)
The relationship between blue nevus and vitiligo.The Tohoku journal of experimental medicine, 57 2-3
O. Stegmaier (1961)
Transplantation of Melanocytic Nevi Into Vitiliginous SkinJournal of Investigative Dermatology, 36
M. Leider, A. Fisher (1949)
Fate of central nevus in leukoderma acquisitum centrifugum.Archives of dermatology and syphilology, 60 6
R. Hiramoto, D. Pressman (1957)
Immunohistochemical staining properties of human skin and some related tumors.Cancer research, 17 11
A. Klem (1951)
Leukoderma Acquisitum Centrifugum ("Vitiligo peri-naevique")Acta Dermatovener, 31
W. Sumner, A. Foraker (1960)
Spontaneous regression of human melanoma. Clinical and experimental studiesCancer, 13
J. S. Stehlin (1963)
Effect of Topical Hormones and Other Dermatologicals on Melanin PigmentationAnn NY Acad Sci, 100
(1960)
Manual of Histologic and Special Staining Technics, Armed Forces Institute of Pathology
Abstract A series of diverse neuroectodermally derived tumors associated with halos of leukoderma is presented. Clinically these lesions have in common a centrally placed, usually pigmented tumor encircled by a zone of hypopigmentation. The histological findings include (1) reduction or absence of epidermal melanin, but persistence of amelanotic melanocytes in the leukodermic halo; (2) a variety of tumors including nevuscell nevus, neuroid nevus, blue nevus, neurofibroma, and malignant melanoma; (3) variable numbers of "small dark cells" whose nature is unclear, and which probably represent in part small nevus cells and in part lymphoid cells; and (4) damage to some tumor cells which presumably could be the cause of their destruction. Also presented are histochemical demonstrations of tyrosinase activity and immunohistochemical studies for presence of γ-globulin in the tumors. Using the fluorescent antibody technique it was not possible to show γ-globulins in patients' sera directed against their tumors. The relationship of developing hypopigmentation to the spontaneous regression of cutaneous neuroectodermally derived tumors is discussed. References 1. Manual of Histologic and Special Staining Technics, Armed Forces Institute of Pathology , ed 2, New York: McGraw-Hill Book Company, 1960. 2. Sutton, R. L.: Unusual Variety of Vitiligo (Leucoderma Acquisitum Centrifugum) , J Cut Dis 34:797-800 ( (Nov) ) 1916. 3. Graham, J. H.; Fogel, N. A.; and Burgoon, C. F.: Multiple Nonpigmented Nevi in Negro Child , Arch Derm 88:313-319 ( (Sept) ) 1963.Crossref 4. Masson, P.: My Conception of Cellular Nevi , Cancer 4:9-38 ( (Jan) ) 1951.Crossref 5. Shapiro, L., and Kopf, A. W.: Leukoderm Acquisitum Centrifugum: Unusual Case , Arch Derm , this issue, p 64. 6. Levy, H. B., and Sober, H. A: Simple Chromatographic Method for Preparation of Gamma Globulin , Proc Soc Exp Biol Med 103:250, 1960.Crossref 7. Riggs, J. L.; Loh, P. C.; and Eveland, W. C.: Simple Fractionation Method for Preparation of Fluorescein Labeled Gamma Globulin , Proc Soc Exp Biol Med 105:655-658, 1960.Crossref 8. Stegmaier, O. C.: Life Cycle of Nevus , Mod Med 31:79-91 ( (June 24) ) 1963. 9. Stegmaier, O. C.: Transplantation of Melanocytic Nevi into Vitiliginous Skin , J Invest Derm 36:47-54 ( (Jan) ) 1961. 10. Leszczynski, R.: Über Suttonsche Krankheit (Leucoderma acquisitum centrifugum) , Derm Wschr 82:575-578 ( (April 24) ) 1926. 11. Findlay, G. H.: Histology of Sutton's Nevus , Brit J Derm 69:389-394 ( (Nov) ) 1957.Crossref 12. Iijima, S., and Kanazawa, T.: Relationship Between Blue Nevus and Vitiligo , Tohoku J Exp Med 57:144, 1953.Crossref 13. Merklen, F. P., and Pelbois, F.: Cas type de maladie de Sutton vraie: Leucodermie centrifuge acquise geometriquement centree par un naevus pigmentaire , Bull Soc Franc Derm Syph 56:12, 1949. 14. Merklen, F. P., and Pelbois, F.: Maladie de Sutton à élèments multiples plus ou moins typiques avec taches achromiques circulaires sans centre naevique cliniquement apparent , Bull Soc Franc Derm Syph 56:244-245, 1949. 15. Matuzawa, T.; Watanabe, M.; and Kondo, R.: Case of Leucoderma in X-rayed Portion of Patient With Melanosarcoma , Shinshu Med J 2:54( (254) ), 58(258), 1953. 16. Miura, O., and Nakajima, T.: Über einen Fall von gleichzeitiger Ausbreitung von Depigmentierung mit parallelverlaufendem Melanomalignom , Hautarzt 10:357-359, 1959. 17. Kärcher, K. H.: Systematisierte Depigmentierung bei strahlenbehandelten Melanomen , Dermatologica 120:255-263 ( (May) ) 1960.Crossref 18. Ito, M., and Yoshida, Y.: Malignant Melanoma , Tohoku J Exp Med 55( (suppl 1) ):60-71 (Feb 9) 1952.Crossref 19. Sumner, W. C.: Spontaneous Regression of Human Melanoma , Cancer 6:1040-1043 ( (Sept) ) 1953.Crossref 20. Sumner, W. C., and Foraker, A. G.: Spontaneous Regression of Human Melanoma, Clinical and Experimental Studies , Cancer 13:79-81 ( (Jan) -Feb) 1960.Crossref 21. Das Gupta, T.; Bowden, L.; and Berg, J. W.: Malignant Melanoma of Unknown Primary Origin , Surg Gynec Obstet 117:341-345 ( (Sept) ) 1963. 22. Stehlin, J. S., in discussion on Spoor, H. J.: Effect of Topical Hormones and Other Dermatologicals on Melanin Pigmentation , Ann NY Acad Sci 100:57 ( (Feb 15) ) 1963. 23. Tanaka, H.: Studies on Pigmentation in Nevoid, Neoplastic, and Other Diseases of Skin , Jap J Derm 68:1-59, 1958. 24. Frank, S. B., and Cohen, H. J.: Halo Nevus , Arch Derm 89:367-373 ( (March) ) 1964.Crossref 25. Klem, A.: Leukoderma Acquisitum Centrifugum ("Vitiligo peri-naevique") , Acta Dermatovener 31:452, 1951. 26. Pinkus, H.: Vitiligo—What is It? J Invest Derm 32:281-284, 1959.Crossref 27. Lund, H. Z.: " Pigment Cell Neoplasms: Problems in Diagnosis of Early Lesion in Proceedings of Fourth National Cancer Conference , Philadelphia & Montreal: J. B. Lippincott Co., 1960, pp 619-622. 28. Lund, H. Z., and Kraus, J. M.: Melanotic Tumor of Skin , sect 1, pt (3) , Armed Forces Institute of Pathology, 1962. 29. Leider, M., and Fisher, A. A.: Fate of Central Nevus in Leukoderma Acquisitum Centrifugum , Arch Derm Syph 60:1160-1166 ( (Dec) ) 1949.Crossref 30. Rohdenburg, G. L.: Spontaneous Recession of Multiple Pigmented Moles , Arch Path Lab Med 4:528-529, 1927. 31. Lorincz, A. L.: " Pigmentation ," in Rothman, S.: Physiology and Biochemistry of Skin , Chicago: University of Chicago Press, 1954. 32. Goldman, L.: Cancer Immunology , Arch Derm 84:948-959 ( (Dec) ) 1961.Crossref 33. Goldman, L.: In discussion of Boardman, C. R.: Arch Derm 85:554-555 ( (April) ) 1962. 34. Mason, H. S., et al: Melanoma Chemotherapy: I. Some Properties of Antimelanin Gamma Globulin , Cancer Res 14:648-650 ( (Oct) ) 1954. 35. Vial, A. B., and Callahan, W.: Effect of Some Tagged Antibodies on Human Melanoblastoma , Cancer 10:999-1003 ( (Sept) -Oct) 1957.Crossref 36. Woods, A. C., and Little, M. F.: Uveal Pigment—Hypersensitivity and Therapeusis , Arch Ophthal 9:200-225 ( (Feb 14) ) 1933.Crossref 37. Woods, A. C.: Allergy in its Relation to Sympathetic Ophthalmia , New York J Med 36:67-83 ( (Jan 15) ) 1936. 38. Friedenwald, J. S.: Notes on Allergy Theory of Sympathetic Ophthalmia , Amer J Ophthal 17:1008-1018, 1934. 39. Cinader, B.: Immunochemistry of Enzymes , Ann NY Acad Sci 103:495-548 ( (May 8) ) 1963.Crossref 40. Owen, R. D., and Markert, C. L.: Effects of Antisera on Tyrosinase in Glomerella Extracts , J Immunol 74:257-259, 1955. 41. Wheeler, A. H.: cited by Lerner, A. B., and Fitzpatrick, T. B.: " Control of Melanogenesis in Human Pigment Cells ," in Gordon, M. (ed.): Pigment Cell Growth , New York: Academic Press, Inc., 1953. 42. Gordon, D. M.: Night-Blinding Retinochoroidopathies , Seminar Report 3:21-28, 1958. 43. Netherton, E. W., and Curtis, G. H.: Leukoderma Acquisitum Centrifugum , Arch Derm 39:163 ( (Jan) ) 1939. 44. Bunch, J. L.: Vitiligo Patches with Central Pigmented Mole , Proc Roy Soc Med (Sect Dis Child) 11:17-18 ( (Jan 17) ) 1918. 45. Boardman, C. R.: Perinevoid Vitiligo (Leukoderma Acquisitum Centrifugum) , Arch Derm 85:554-555 ( (April) ) 1962.Crossref 46. Montpellier, J.: Vitiligo a debut perinaevique , Bull Soc Franc Derm Syph 29:81-83 ( (Feb) ) 1922. 47. Mackay, I. R., and Burnet, F. M.: Autoimmune Diseases: Pathogenesis, Chemistry and Therapy , American Lecture Series, Springfield: Charles C Thomas, Publisher, 1963. 48. Blakemore, W. S., and McKenna, J. M.: Antibodies Reactive With Antigens Derived From HeLa and J 111 in Patients with Malignancies , Surgery 52:213-219 ( (July) ) 1962. 49. Hiromoto, R., and Pressman, D.: Immunohistochemical Staining Properties of Human Skin and Some Related Tumors , Cancer Res 17:1135-1137 ( (Dec) ) 1957. 50. Makari, J. G.: Recent Studies in Immunology of Cancer: II. Demonstration of Antibodies to Cancer , J Amer Geriat Soc 8:4-15 ( (Jan) ) 1960. 51. Grupper, M. C.: Activité anti-tyrosinasique du serum: note préliminaire sur les possibilités d'un sérodiagnostic du mélanome malin , Bull Soc Franc Derm Syph 61:145-147, 1954. 52. Becker, S. W., Jr., and Spencer, M. C.: Evaluation of Monobenzone , JAMA 180:279-284 ( (April 28) ) 1962.Crossref 53. Cornbleet, T.; Barsky, S.; and Latoni, J.: Acquired Halo Nevus-like Formation from Benoquin , Arch Derm 78:276-277 ( (Aug) ) 1958. 54. Braitman, M.: Junction Nevus with Spontaneous Clinical Disappearance , Arch Derm 77:721 ( (June) ) 1958.Crossref 55. Shelley, W. B.: Photographic Evidence of the Spontaneous Involution and Disappearance of Pigmented Nevi , Arch Derm 81:208-209 ( (Feb) ) 1960.Crossref 56. Anderson, N. P.: Moles, Melanomas and Epitheliomas in Children , Calif Med 78:17-20 ( (Jan) ) 1953. 57. Stegmaier, O. C., and Becker, S. W., Sr.: Incidence of Melanocytic Nevi in Young Adults , J Invest Derm 34:125-129 ( (Feb) ) 1960. 58. Stegmaier, O. C.: Natural Regression of Melanocytic Nevus , J Invest Derm 32:413-420 ( (March) ) 1959.Crossref 59. Allen, A. C.: Juvenile Melanomas of Children and Adults and Melanocarcinomas of Children , Arch Derm 82:325-335 ( (Sept) ) 1960.Crossref 60. Everson, T. C., and Cole, W. H.: Spontaneous Regression of Malignant Disease , JAMA 169:1758-1759, ( (April 11) ) 1959.Crossref 61. Allen, E. P.: Malignant Melanoma, Spontaneous Regression After Pregnancy , Brit Med J 2:1067 ( (Oct 29) ) 1955.Crossref 62. Nungester; Beierwaltes; and Knorpp, in personal communication to Vial, A. B. 63. Callahan, W.: The Effect of Some Antibodies on Human Melanoblastoma , Cancer 10:999-1031 ( (Sept) -Oct) 1957.Crossref 64. Johnson, J. C.: Melanoma , J Cut Dis 23:49-71 ( (Feb) ) 1905. 65. Cavell, B.: Transplacental Metastasis of Malignant Melanoma , Acta Paediat 146:37-40, 1963.Crossref 66. Burdick, K. H., and Hawk, W. A.: Vitiligo in Case of Vaccinia Virus-Treated Melanoma , Cancer 17:708-712 ( (June) ) 1964Crossref 67. McGuinnes, B. W.: Melanocyte-stimulating Hormone: Clinical and Laboratory Study , Ann NY Acad Sci 100:640-657 ( (Feb 15) ) 1963.Crossref
Archives of Dermatology – American Medical Association
Published: Jul 1, 1965
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