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Potentiation of Hyperpigmentation From X-Radiation: Effects of Demethylchlortetracycline Therapy

Potentiation of Hyperpigmentation From X-Radiation: Effects of Demethylchlortetracycline Therapy Abstract It is well known that hyperpigmentation may develop in darker-skinned races after even small doses of x-radiation. The skin of lightly pigmented Negroes may become nearly black after a few weekly doses of 75 roentgens (r) of superficial x-ray therapy. This effect occurs without visible inflammatory change. During the past few years, attention has been called to photosensitivity, or more properly, phototoxic cutaneous reactions in patients exposed to sunlight during demethylchlortetracycline administration.1,2 The effect has been shown to be a quantitative one,3 ie, developing mainly when a minimum of 600 mg of this drug was given daily. It was further shown by Schorr and Monash4 to be potentiated by both ultraviolet rays of wavelength between 2,800 Angstroms (A) and 3,200 A, and by rays with longer wavelength than 3,150 A which pass through common window glass. Report of Case Recently, I observed the development of moderately severe References 1. Falk, M.: Light Sensitivity Due to Demethylchlortetracycline , JAMA 172:1156, 1960.Crossref 2. Soslaw, S.: Demethylchlortetracycline Phototoxicity , New Eng J Med 264:1301, 1961.Crossref 3. Cahn, M.; Levy, E.; and McMillen, J.: Nature and Incidence of Photosensitivity Reactions to Demethylchlortetracycline , Arch Derm 84:485, 1961.Crossref 4. Schorr, W., and Monash, S.: Photo-Irradiation Studies of Two Tetracyclines , Arch Derm 88:440, 1963.Crossref 5. Zelickson, A., and Zeller, H.: New and Unusual Reaction to Chlorpromazine , JAMA 188:144, 1964.Crossref 6. Greiner, A.: Skin Pigmentation and Corneal and Lens Opacities With Prolonged Chlorpromazine Therapy , Canad Med Ass J 90:663, 1964. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Potentiation of Hyperpigmentation From X-Radiation: Effects of Demethylchlortetracycline Therapy

CORMIA, FRANK E.
Archives of Dermatology , Volume 90 (6) – Dec 1, 1964
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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1964.01600060090015
Publisher site
See Article on Publisher Site

Abstract

Abstract It is well known that hyperpigmentation may develop in darker-skinned races after even small doses of x-radiation. The skin of lightly pigmented Negroes may become nearly black after a few weekly doses of 75 roentgens (r) of superficial x-ray therapy. This effect occurs without visible inflammatory change. During the past few years, attention has been called to photosensitivity, or more properly, phototoxic cutaneous reactions in patients exposed to sunlight during demethylchlortetracycline administration.1,2 The effect has been shown to be a quantitative one,3 ie, developing mainly when a minimum of 600 mg of this drug was given daily. It was further shown by Schorr and Monash4 to be potentiated by both ultraviolet rays of wavelength between 2,800 Angstroms (A) and 3,200 A, and by rays with longer wavelength than 3,150 A which pass through common window glass. Report of Case Recently, I observed the development of moderately severe References 1. Falk, M.: Light Sensitivity Due to Demethylchlortetracycline , JAMA 172:1156, 1960.Crossref 2. Soslaw, S.: Demethylchlortetracycline Phototoxicity , New Eng J Med 264:1301, 1961.Crossref 3. Cahn, M.; Levy, E.; and McMillen, J.: Nature and Incidence of Photosensitivity Reactions to Demethylchlortetracycline , Arch Derm 84:485, 1961.Crossref 4. Schorr, W., and Monash, S.: Photo-Irradiation Studies of Two Tetracyclines , Arch Derm 88:440, 1963.Crossref 5. Zelickson, A., and Zeller, H.: New and Unusual Reaction to Chlorpromazine , JAMA 188:144, 1964.Crossref 6. Greiner, A.: Skin Pigmentation and Corneal and Lens Opacities With Prolonged Chlorpromazine Therapy , Canad Med Ass J 90:663, 1964.

Journal

Archives of Dermatology – American Medical Association

Published: Dec 1, 1964

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