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Nonthrombocytopenic Purpura Due to Carbromal Ingestion

Nonthrombocytopenic Purpura Due to Carbromal Ingestion Abstract Three cases of a pruritic, nonthrombocytopenic, purpuric eruption due to carbromal, a mild hypnotic, are presented. The eruption was characterized by a petechial, purpuric, slightly scaling, generalized condition whose onset occurred on the extremities. On cessation of the drug, the eruption slowly subsided and pruritus disappeared. Laboratory studies, including bleeding time, clotting time, prothrombin time, and platelet counts, were normal. The basophil degranulation test was strongly positive in one patient a week after cessation of the drug but only weakly positive after another interval of five weeks. The mechanism of the reaction is thought to be of an antigen antibody type at or near the vascular endothelium with the drug acting as a haptene combining with a body protein to form the antigen. References 1. Carbromal 4 grains, plus pentobarbital sodium 11/2 grains. 2. Buck, H. W., and Mitchell, J. C.: Canad Med Ass J 88:1116, 1963. 3. Goodman, L. S., and Gilman, A.: Pharmacological Basis of Therapeutics , ed 2, New York: The Macmillan Company, 1955, p 124. 4. Daughters, K.: Personal communication to the author. 5. Hill, B. H.: New Zeal Med J 56:570, 1957. 6. MacGregor, A. C.: Practitioner 184:15, 1960. 7. Marcussen, P. V.: Acta Dermatovener 38:398, 1958. 8. Loeb, H.: Arch Derm Syph (Berlin) 131:128, 1921.Crossref 9. Borrie, P.: Brit Med J 1:645, 1955.Crossref 10. Peterkin, G. A. G.: Arch Derm Syph 58:249, 1948.Crossref 11. Ackroyd, J. F.: Clin Sci 7:249, 1949. 12. Ackroyd, J. F.: Amer J Med 14:605, 1953.Crossref 13. Sneddon, R.: Brit J Derm 66:262, 1954.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Nonthrombocytopenic Purpura Due to Carbromal Ingestion

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1964.01590260038006
Publisher site
See Article on Publisher Site

Abstract

Abstract Three cases of a pruritic, nonthrombocytopenic, purpuric eruption due to carbromal, a mild hypnotic, are presented. The eruption was characterized by a petechial, purpuric, slightly scaling, generalized condition whose onset occurred on the extremities. On cessation of the drug, the eruption slowly subsided and pruritus disappeared. Laboratory studies, including bleeding time, clotting time, prothrombin time, and platelet counts, were normal. The basophil degranulation test was strongly positive in one patient a week after cessation of the drug but only weakly positive after another interval of five weeks. The mechanism of the reaction is thought to be of an antigen antibody type at or near the vascular endothelium with the drug acting as a haptene combining with a body protein to form the antigen. References 1. Carbromal 4 grains, plus pentobarbital sodium 11/2 grains. 2. Buck, H. W., and Mitchell, J. C.: Canad Med Ass J 88:1116, 1963. 3. Goodman, L. S., and Gilman, A.: Pharmacological Basis of Therapeutics , ed 2, New York: The Macmillan Company, 1955, p 124. 4. Daughters, K.: Personal communication to the author. 5. Hill, B. H.: New Zeal Med J 56:570, 1957. 6. MacGregor, A. C.: Practitioner 184:15, 1960. 7. Marcussen, P. V.: Acta Dermatovener 38:398, 1958. 8. Loeb, H.: Arch Derm Syph (Berlin) 131:128, 1921.Crossref 9. Borrie, P.: Brit Med J 1:645, 1955.Crossref 10. Peterkin, G. A. G.: Arch Derm Syph 58:249, 1948.Crossref 11. Ackroyd, J. F.: Clin Sci 7:249, 1949. 12. Ackroyd, J. F.: Amer J Med 14:605, 1953.Crossref 13. Sneddon, R.: Brit J Derm 66:262, 1954.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Feb 1, 1964

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