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Reactions to Ammonium Persulfate

Reactions to Ammonium Persulfate Abstract A number of patients have been seen with generalized histamine reactions following the use of a hair bleach. Similar urticarial and dermatitic reactions were seen on the hands of hairdressers handling this bleach preparation. The responsible agent was found to be ammonium persulfate. Evidence is given that this compound releases histamine from the skin in susceptible persons. It is a weak histamine liberator. Passive transfer studies were negative. The mechanism of action could be either direct histamine liberation or antibody-mediated. References 1. This investigation was very kindly done for us by Dr. J. L. Mongar of the Pharmacology Department, University College, London. 2. Bonnevie, P.: Aetologie und Pathogenese der Eczemkrankheit , Kopenhagen: Nyt Nordisk Forlag, 1939. 3. Warin, R. P.: The Effect of Aspirin in Chronic Urticaria , Brit J Derm 72:350, 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Reactions to Ammonium Persulfate

Archives of Dermatology , Volume 88 (6) – Dec 1, 1963

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1963.01590240136022
Publisher site
See Article on Publisher Site

Abstract

Abstract A number of patients have been seen with generalized histamine reactions following the use of a hair bleach. Similar urticarial and dermatitic reactions were seen on the hands of hairdressers handling this bleach preparation. The responsible agent was found to be ammonium persulfate. Evidence is given that this compound releases histamine from the skin in susceptible persons. It is a weak histamine liberator. Passive transfer studies were negative. The mechanism of action could be either direct histamine liberation or antibody-mediated. References 1. This investigation was very kindly done for us by Dr. J. L. Mongar of the Pharmacology Department, University College, London. 2. Bonnevie, P.: Aetologie und Pathogenese der Eczemkrankheit , Kopenhagen: Nyt Nordisk Forlag, 1939. 3. Warin, R. P.: The Effect of Aspirin in Chronic Urticaria , Brit J Derm 72:350, 1960.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1963

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