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Response of Psoriatic Lesions to Topical Fluocinolone Acetonide

Response of Psoriatic Lesions to Topical Fluocinolone Acetonide Abstract This study consisted of an additional 6-10 month follow-up of 214 patients (previously reported on)1 with psoriasis treated with fluocinolone acetonide cream and occlusive dressings. All but one of 102 patients with intertriginous involvement with psoriasis responded well to the topical use of fluocinolone acetonide without an occlusive dressing. They remained either free or nearly free of lesions by intermittent treatment. Approximately one-third of the 116 patients with localized psoriasis treated with a moist occlusive dressing plus fluocinolone acetonide cream had no recurrence after cessation of treatment. All patients, but 2 responded to re-treatment and remained at least 80% clear on intermittent applications. In 55 patients with widespread psoriasis who were treated with the corticosteroid cream and occlusive dressings also showed a good initial response. The prolonged effectiveness, however, was not as good as in the other 2 groups of patients. Except for 2 patients with miliaria who developed psoriatic lesions at the site of the miliaria, all complications cleared on temporary interruption of treatment. References 1. Fluocinolone acetonide cream, 0.025% supplied by Dr. Kenneth Dumas, Syntex Laboratories, Inc., New York. 2. Supplied by Messrs. R. Sorenson, L. Whalen, and L. Lehr, Minnesota, Mining and Manufacturing Co., St. Paul. 3. Tye, M. J., and Schiff, B. L.: Treatment of Psoriatic Lesions With Topical Fluocinolone Acetonide and Moist Dressings , J. Invest. Derm. 38: 321-326 ( (June) ) 1962. 4. Scholtz, J. R.: A New Corticoid for Topical Therapy Fluocinolone Acetonide , Calif. Med. 95: 224-226 ( (Oct.) ) 1961. 5. Witten, V. H.: Newer Dermatologic Methods for Using Corticosteroids More Efficaciously , Med. Clin. N. Amer. 45:857-868 ( (July) ) 1961. 6. Scholtz, J. R.: Topical Therapy of Psoriasis with Fluocinolone Acetonide , Arch. Derm. 84:1029 ( (Dec.) ) 1961.Crossref 7. Scher, R. K.: Treatment of Refractory Dermatoses with Fluocinolone Acetonide , Cur. Ther. Res. 3:461 ( (Nov.) ) 1961. 8. Sulzberger, H. B., and Witten, V. H.: Thin Pliable Plastic Films in Topical Dermatologic Therapy , Arch. Derm. 84:1027-1028 ( (Dec.) ) 1961.Crossref 9. Fleischmajer, R.: The Lack of Systemic Hydrocortisone Effects After Massive and Prolonged External Applications , J. Invest. Derm. 36:11-16 ( (Jan.) ) 1961. 10. Goldman, L., and Cohen, W.: Total Body Inunction as Topical Corticosteroid Therapy , Arch. Derm. 85:226-228 ( (Feb.) ) 1962. 11. Shelley, W. B., and Horvath, P. N.: Experimental Miliaria in Man: Production of Sweat Retention Anidrosis and Miliaria Crystallina by Various Kinds of Injury , J. Invest. Derm. 14:9-20, 1950. 12. Peck, S. M.; Michelfelder, T. J., and Palitz, L. L.: Further Studies on the Mechanism of Adhesive Tape Dermatitis , Arch. Derm. 63:289-311, 1951.Crossref 13. Loewenthal, L. J. A.: The Pathogenesis of Miliaria , Arch. Derm. 84:2-17, 1961.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Response of Psoriatic Lesions to Topical Fluocinolone Acetonide

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1963.01590130033007
Publisher site
See Article on Publisher Site

Abstract

Abstract This study consisted of an additional 6-10 month follow-up of 214 patients (previously reported on)1 with psoriasis treated with fluocinolone acetonide cream and occlusive dressings. All but one of 102 patients with intertriginous involvement with psoriasis responded well to the topical use of fluocinolone acetonide without an occlusive dressing. They remained either free or nearly free of lesions by intermittent treatment. Approximately one-third of the 116 patients with localized psoriasis treated with a moist occlusive dressing plus fluocinolone acetonide cream had no recurrence after cessation of treatment. All patients, but 2 responded to re-treatment and remained at least 80% clear on intermittent applications. In 55 patients with widespread psoriasis who were treated with the corticosteroid cream and occlusive dressings also showed a good initial response. The prolonged effectiveness, however, was not as good as in the other 2 groups of patients. Except for 2 patients with miliaria who developed psoriatic lesions at the site of the miliaria, all complications cleared on temporary interruption of treatment. References 1. Fluocinolone acetonide cream, 0.025% supplied by Dr. Kenneth Dumas, Syntex Laboratories, Inc., New York. 2. Supplied by Messrs. R. Sorenson, L. Whalen, and L. Lehr, Minnesota, Mining and Manufacturing Co., St. Paul. 3. Tye, M. J., and Schiff, B. L.: Treatment of Psoriatic Lesions With Topical Fluocinolone Acetonide and Moist Dressings , J. Invest. Derm. 38: 321-326 ( (June) ) 1962. 4. Scholtz, J. R.: A New Corticoid for Topical Therapy Fluocinolone Acetonide , Calif. Med. 95: 224-226 ( (Oct.) ) 1961. 5. Witten, V. H.: Newer Dermatologic Methods for Using Corticosteroids More Efficaciously , Med. Clin. N. Amer. 45:857-868 ( (July) ) 1961. 6. Scholtz, J. R.: Topical Therapy of Psoriasis with Fluocinolone Acetonide , Arch. Derm. 84:1029 ( (Dec.) ) 1961.Crossref 7. Scher, R. K.: Treatment of Refractory Dermatoses with Fluocinolone Acetonide , Cur. Ther. Res. 3:461 ( (Nov.) ) 1961. 8. Sulzberger, H. B., and Witten, V. H.: Thin Pliable Plastic Films in Topical Dermatologic Therapy , Arch. Derm. 84:1027-1028 ( (Dec.) ) 1961.Crossref 9. Fleischmajer, R.: The Lack of Systemic Hydrocortisone Effects After Massive and Prolonged External Applications , J. Invest. Derm. 36:11-16 ( (Jan.) ) 1961. 10. Goldman, L., and Cohen, W.: Total Body Inunction as Topical Corticosteroid Therapy , Arch. Derm. 85:226-228 ( (Feb.) ) 1962. 11. Shelley, W. B., and Horvath, P. N.: Experimental Miliaria in Man: Production of Sweat Retention Anidrosis and Miliaria Crystallina by Various Kinds of Injury , J. Invest. Derm. 14:9-20, 1950. 12. Peck, S. M.; Michelfelder, T. J., and Palitz, L. L.: Further Studies on the Mechanism of Adhesive Tape Dermatitis , Arch. Derm. 63:289-311, 1951.Crossref 13. Loewenthal, L. J. A.: The Pathogenesis of Miliaria , Arch. Derm. 84:2-17, 1961.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jan 1, 1963

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