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S. Sanders , M. Brodey (1960)
Corticosteroid Treatment of PemphigusArch. Derm., 82
J. Paris (1961)
Pituitary-adrenal suppression after protracted administration of adrenal cortical hormones.Proceedings of the staff meetings. Mayo Clinic, 36
R. Stoughton (1956)
Long-term management of pemphigus vulgaris with corticotropin (ACTH).Journal of the American Medical Association, 160 12
W. F. Lever (1953)
PemphigusMedicine, 32
M. Costello, L. Jaimovich, M. Dannenberg (1959)
[Treatment of pemphigus with corticosteroids].Revista de la Asociacion Medica Argentina, 73
M. Per, A. Mashkilleĭson (1962)
[Remote results of continuous systemic corticosteroid treatment in pemphigus].Dermatologica, 124
R. Irby, E. Toone, B. Wittkamp, H. Wiesinger (1964)
CATARACTS IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH CORTICOSTEROIDS.GP, 29
L. Reznick, W. Lever, C. Frazier (1956)
Treatment of pemphigus with ACTH, cortisone and prednisone; results obtained in twenty-five cases over a period of five years.The New England journal of medicine, 255 7
L. Reznick , W. F. Lever (1956)
Treatment of Pemphigus with ACTH, Cortisone and PrednisoneNew Engl. J. Med., 255
W. Wittels (1960)
Ergebnisse der Kortikosteroidtherapie beim Pemphigus vulgarisDerm. Wschr., 141
H. O. Perry (1961)
Pemphigus FoliaceusArch. Derm., 85
C. Stevenson (1960)
TREATMENT IN BULLOUS DISEASES WITH CORTICOSTEROID DRUGS AND CORTICOTROPHIN.British Journal of Dermatology, 72
W. Linton, G. Craig (1961)
Pemphigus: a comparison of the results of treatment at the Royal Victoria Hospital, Montreal, in the steroid and presteroid eras.Canadian Medical Association journal, 85
R. B. Oglesby , R. L. Black, L. Von Sallmann (1961)
Cataracts in Patients with Rheumatic Diseases Treated with CorticosteroidsArch. Ophthal., 66
Abstract Forty-six patients with pemphigus were placed on treatment with corticosteroids between April, 1950, and October, 1959. Their state was determined as of Oct. 1, 1961. There were 32 patients with pemphigus vulgaris, of whom 21 were living and ambulatory on Oct. 1, 1961. Of the 21 living patients, 5 were free of lesions without treatment; 5 were free of lesions but were still receiving treatment; and 11 had a few lesions and were receiving treatment. Eleven patients had died. At the time of death 5 were free of lesions; 4 had a few lesions; and 2 showed extensive involvement. Of the 11 deaths 3 were attributable and 3 probably attributable to therapy with corticosteroids; while 5 patients had died of unrelated causes. One patient with pemphigus vegetans was free of lesions without treatment. Of the 11 patients with pemphigus foliaceus, 6 were free of lesions and without treatment. Five patients had died, 4 of unrelated causes while free of lesions, and I generalized pemphigus foliaceus while not under our care andnot receiving corticosteroids. Of 2 patients with pemphigus erythematosus one was free of lesions and the other had a few lesions. Neither was receiving any treatment. In pemphigus vulgaris early diagnosis and prompt treatment with high doses of corticosteroids is of great importance. If vigorous and prolonged initial treatment is given, it is more likely that the patient can be carried on small maintenance doses than if the initial treatment is less intensive in amount and duration. After the initial administration of high doses the dosage is reduced in a "logarithmic fashion" to the lowest level adequate for maintenance. During exacerbations large doses of corticosteroids are again required. In contrast to early pemphigus vulgaris, treatment may be withheld in early pemphigus foliaceus so long as the disease remains localized and mild. Side-reactions to the corticosteroids were rather common, especially compression fractures of vertebral bodies, bacterial infections, peptic ulcer, and mental changes. In 2 patients central posterior subcapsular cataracts developed as a result of treatment with large doses of corticosteroids. Concurrent administration of testosterone and estrogens was regarded as effective prophylaxis against vertebral fractures. References 1. One cortisone equivalent is equal to 1 tablet of cortisone (25 mg.); 1 tablet of prednisone (5 mg.); 1 tablet of methyl prednisone (4 mg.); 1 tablet of triamcinolone (4 mg.), and one-half tablet of betamethasone (0.3 mg.). 2. Reznick, L.; Lever, W. F., and Frazier, C. N.: Treatment of Pemphigus with ACTH, Cortisone and Prednisone , New Engl. J. Med. 255:305-315 ( (Aug.) ) 1956.Crossref 3. Sanders, S.; Brodey, M., and Nelson, C. T.: Corticosteroid Treatment of Pemphigus , Arch. Derm. 82:717-724 ( (Nov.) ) 1960.Crossref 4. Stoughton, R. B.: Long-Term Management of Pemphigus Vulgaris with Corticotropin (ACTH) , J.A.M.A. 160:1011-1014 ( (March) ) 1956.Crossref 5. Costello, M. J.; Jaimovitch, L., and Dannenberg, M.: Treatment of Pemphigus with Corticosteroids , J.A.M.A. 165:1249-1255 ( (Nov.) ) 1957.Crossref 6. Stevenson, C. J.: Treatment in Bullous Diseases with Corticosteroid Drugs and Corticotrophin , Brit. J. Derm. 72:11-21 ( (Jan.) ) 1960.Crossref 7. Wittels, W.: Ergebnisse der Kortikosteroidtherapie beim Pemphigus vulgaris , Derm. Wschr. 141:401-410 ( (April) ) 1960. 8. Perry, H. O.: Pemphigus Foliaceus , Arch. Derm. 85:52-69 ( (Jan.) ) 1961.Crossref 9. Linton, W. T. R., and Craig, G. E.: Pemphigus: A Comparison of the Results of Treatment at the Royal Victoria Hospital, Montreal, in the Steroid and Presteroid Eras , Canad. Med. Ass. J. 85:1192-1194 ( (Nov.) ) 1961. 10. Per, M. I., and Mashkilleison, A. L.: Remote Results of Continuous Systemic Corticosteroid Treatment in Pemphigus , Dermatologica 124:99-109, 1962.Crossref 11. Lever, W. F.: Pemphigus , Medicine 32:1-123 ( (Feb.) ) 1953.Crossref 12. Oglesby, R. B.; Black, R. L.; Von Sallmann, L., and Bunim, J. J.: Cataracts in Rheumatoid Arthritis Patients Treated with Corticosteroids , Arch. Ophthal. 66:519-523 ( (Oct.) ) 1961.Crossref 13. Oglesby, R. B.; Black, R. L.; Von Sallmann, L., and Bunim, J. J.: Cataracts in Patients with Rheumatic Diseases Treated with Corticosteroids , Arch. Ophthal. 66:625-630 ( (Nov.) ) 1961.Crossref 14. Paris, J.: Pituitary-Adrenal Suppression after Protracted Administration of Adrenal Cortical Hormones , Proc. Mayo Clin. 36:305-317 ( (June) ) 1961.
Archives of Dermatology – American Medical Association
Published: Jan 1, 1963
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