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Intradermal Hyaluronidase Corticosteroid Therapy

Intradermal Hyaluronidase Corticosteroid Therapy Abstract The recent introduction of intralesional steroid injections in the treatment of chronic miscellaneous dermatoses represents a definite advance in dermatologic therapy. Reports of this modality are not numerous, but there is general agreement concerning its efficacy.1,2 The advantages of this procedure are based on the fact that instead of the indirect oral route which requires alimentation and metabolization of the drug, the steroid is deposited in the immediate site of the dermatitis, thus effecting a direct tissue response. Generalized untoward reactions are, therefore, extremely rare, and frequently the therapeutic response is prolonged in contrast to that frequently observed after cessation of oral steroid administration. The method is not applicable to the treatment of extensive dermatoses, since only small areas can be treated at one time. There is little pain associated with the injections, though this can be decreased by the addition of procaine to the mixture and by spraying References 1. Orentreich, N., and March, C.: Intradermal Triamcinolone Acetonide and Diacetate: Healing of Persistent Penile Plaques Due to Distinctive, Exudative, Discoid and Lichenoid Chronic Dermatosis , J. Urol. 85:827-828 ( (May) ) 1961. 2. Gerard. A. G.: Treatment of Psoriasis with Subdermal Infiltration of Triamcinolone Diacetate Suspension , A.M.A. Arch. Derm. 81:535-538 ( (April) ) 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Intradermal Hyaluronidase Corticosteroid Therapy

EDELSTEIN, A. J.
Archives of Dermatology , Volume 85 (6) – Jun 1, 1962
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1962.01590060045008
Publisher site
See Article on Publisher Site

Abstract

Abstract The recent introduction of intralesional steroid injections in the treatment of chronic miscellaneous dermatoses represents a definite advance in dermatologic therapy. Reports of this modality are not numerous, but there is general agreement concerning its efficacy.1,2 The advantages of this procedure are based on the fact that instead of the indirect oral route which requires alimentation and metabolization of the drug, the steroid is deposited in the immediate site of the dermatitis, thus effecting a direct tissue response. Generalized untoward reactions are, therefore, extremely rare, and frequently the therapeutic response is prolonged in contrast to that frequently observed after cessation of oral steroid administration. The method is not applicable to the treatment of extensive dermatoses, since only small areas can be treated at one time. There is little pain associated with the injections, though this can be decreased by the addition of procaine to the mixture and by spraying References 1. Orentreich, N., and March, C.: Intradermal Triamcinolone Acetonide and Diacetate: Healing of Persistent Penile Plaques Due to Distinctive, Exudative, Discoid and Lichenoid Chronic Dermatosis , J. Urol. 85:827-828 ( (May) ) 1961. 2. Gerard. A. G.: Treatment of Psoriasis with Subdermal Infiltration of Triamcinolone Diacetate Suspension , A.M.A. Arch. Derm. 81:535-538 ( (April) ) 1960.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jun 1, 1962

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