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Treatment of Granuloma Inguinale with Triacetyloleandomycin: Report of a Case

Treatment of Granuloma Inguinale with Triacetyloleandomycin: Report of a Case Abstract Granuloma inguinale (granuloma venereum, donovanosis), a disease of the skin and subcutaneous tissues, usually of the genital region, and seen mainly among the darkskinned races, is still endemic in some parts of the world including southern United States. The etiology, epidemiology, diagnosis, differential diagnosis, and clinical course have been well reviewed by Greenblatt and associates1 and Thambiah.2 Penicillin has proved ineffective, and nonspecific treatment has been generally disappointing and punctuated by relapses. Until the advent of streptomycin, dissemination to other parts of the body, with prolonged disability and even death, resulted directly or indirectly from secondary spread of the lesions from the primary focus. Medina and Alarcón3 reported a fatal case in a white woman of granuloma inguinale with large granulomatous ulcerations on the external genitals, and invasion of vaginal mucosa and uterine cervix. Despite antibiotic treatment, ulcerous lesions on the left leg and an intestinal fistula References 1. Available as Evramycin from Wyeth Laboratorios, Caracas, Venezuela; and as Cyclamycin from Wyeth Laboratories, Philadelphia. 2. Greenblatt, R. B., et al.: Lymphogranuloma Venereum and Granuloma Inguinale , Med. Clin. N. Amer. 43:1493-1506, 1959. 3. Thambiah, A. S.: Venereal Granuloma , Trans. St. John's Derm. Soc. 42:44-48, 1959. 4. Medina, R., and Alarcón, C. J.: Granuloma venéreo diseminado , Dermatología Venezolana 1: 192-196, 1958. 5. Cherny, W. B., et al.: Disseminated Granuloma Inguinale and Its Relationship to Granuloma of the Cervix and Pregnancy , Amer. J. Obstet. Gynec. 74:597-605, 1957. 6. Marmell, M., and Santora, E.: Donovanosis —Granuloma Inguinale Amer. J. Syph. 34:83-90, 1950. 7. Lubowe, I. I.: Granuloma Inguinale (?), Involving the Perineum , A.M.A. Arch Derm. Syph. 66:752-754, 1952.Crossref 8. Marmell, M., and Prigot, A.: Oleandomycin in the Treatment of Donovanosis , Antibiot. Med. 3:263-267, 1956. 9. Celmer, W. D.; Els, H., and Murai, K.: Oleandomycin Derivatives: Preparation and Characterization , in Antibiotics Annual, 1957-1958 , New York, Medical Encyclopedia, Inc., 1958, p. 476. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Treatment of Granuloma Inguinale with Triacetyloleandomycin: Report of a Case

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1961.01580140074009
Publisher site
See Article on Publisher Site

Abstract

Abstract Granuloma inguinale (granuloma venereum, donovanosis), a disease of the skin and subcutaneous tissues, usually of the genital region, and seen mainly among the darkskinned races, is still endemic in some parts of the world including southern United States. The etiology, epidemiology, diagnosis, differential diagnosis, and clinical course have been well reviewed by Greenblatt and associates1 and Thambiah.2 Penicillin has proved ineffective, and nonspecific treatment has been generally disappointing and punctuated by relapses. Until the advent of streptomycin, dissemination to other parts of the body, with prolonged disability and even death, resulted directly or indirectly from secondary spread of the lesions from the primary focus. Medina and Alarcón3 reported a fatal case in a white woman of granuloma inguinale with large granulomatous ulcerations on the external genitals, and invasion of vaginal mucosa and uterine cervix. Despite antibiotic treatment, ulcerous lesions on the left leg and an intestinal fistula References 1. Available as Evramycin from Wyeth Laboratorios, Caracas, Venezuela; and as Cyclamycin from Wyeth Laboratories, Philadelphia. 2. Greenblatt, R. B., et al.: Lymphogranuloma Venereum and Granuloma Inguinale , Med. Clin. N. Amer. 43:1493-1506, 1959. 3. Thambiah, A. S.: Venereal Granuloma , Trans. St. John's Derm. Soc. 42:44-48, 1959. 4. Medina, R., and Alarcón, C. J.: Granuloma venéreo diseminado , Dermatología Venezolana 1: 192-196, 1958. 5. Cherny, W. B., et al.: Disseminated Granuloma Inguinale and Its Relationship to Granuloma of the Cervix and Pregnancy , Amer. J. Obstet. Gynec. 74:597-605, 1957. 6. Marmell, M., and Santora, E.: Donovanosis —Granuloma Inguinale Amer. J. Syph. 34:83-90, 1950. 7. Lubowe, I. I.: Granuloma Inguinale (?), Involving the Perineum , A.M.A. Arch Derm. Syph. 66:752-754, 1952.Crossref 8. Marmell, M., and Prigot, A.: Oleandomycin in the Treatment of Donovanosis , Antibiot. Med. 3:263-267, 1956. 9. Celmer, W. D.; Els, H., and Murai, K.: Oleandomycin Derivatives: Preparation and Characterization , in Antibiotics Annual, 1957-1958 , New York, Medical Encyclopedia, Inc., 1958, p. 476.

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1961

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