Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Dermatological Application of Mepivacaine (Carbocaine): A New Local Anesthetic

Dermatological Application of Mepivacaine (Carbocaine): A New Local Anesthetic Abstract Research for more effective and less toxic local anesthetic agents has, over the years, brought to the physician new and valuable agents. One of the most recently introduced is mepivacaine (Carbocaine).* The purpose of this report is to present our initial clinical experience with this new anesthetic agent in a variety of dermatologic surgical procedures. We thought it of interest to include a brief discussion of some of the commonly employed local anesthetics. Brief History and Description of Local Anesthetics The discovery of cocaine by Nieman in 1860 and its first clinical application by Rotter in 1884 are outstanding landmarks. Equally important is the synthesis of procaine by Einhorn in 1905 and the publication of Regional Anesthesia by Labat in 1922. Following the synthesis of procaine, many other local anesthetic drugs have been developed. Procaine hydrochloride (Novocain) milligram for milligram is still one of the least toxic drugs. Tetracaine hydrochloride References 1. Carbocaine was supplied by the Medical Research Department of Winthrop Laboratories, New York. 2. Coakley, C. S.: Local Anesthesia , Postgrad. Med. 19:360, 1956. 3. Ekenstam, B. AF, and others: Trials with Carbocaine: A New Local Anaesthetic Drug , Brit. J. Anaesth. 28:503 ( (Nov.) ) 1956.Crossref 4. Dhunér, K. G.; Oljelund, O., and Aagesen, G.: Carbocaine-d, 1-N-Methyl-Pipecolic Acid 2, 6-Dimethylanilide: A New Local Anesthetic Agent , Acta chir. scand. 112:350 ( (May 3) ) 1957. 5. Dam, W., and Guldmann, N.: Carbocaine—a New Local Anaesthetic , Acta Anaesth. Scand. 1: 101 ( (Dec.) ) 1957.Crossref 6. Griesser, G.: Erfahrungen mit einem neuen Lokalanaestheticum , Anaesthesist 6:364 ( (Oct.) ) 1957. 7. Griesser, G.: Über ein neues Lokalanaesthetikum, Scandicain , Deut. Med. Wschr. 82:2071 ( (Dec. 6) ) 1957.Crossref 8. Erickson, J. C., III, and Hricke, M. J.: Clinical Evaluation of Mepivacaine, a New Local Anesthetic Agent , Guthrie Clin. Bull. , to be published. 9. Ulfendahl, H. R.: Some Pharmacological and Toxicological Properties of a New Local Anaesthetic, Carbocaine , Acta Anaesth. Scand. 1:81 ( (Dec.) ) 1957.Crossref 10. Luduena, F. P.; Hoppe, J. O.; Coulston, F., and Drobeck, H. P.: The Pharmacology and Toxicology of Mepivacaine, a New Local Anesthetic , Toxicol. & Appl. Pharmacol. 2:295 ( (May) ) 1960. 11. Ekenstam, B. AF; Egner, B., and Pettersson, G.: Local Anaesthetics: I. N-Alkylpyrrolidine and N-Alkyl Piperidine Carboxylic Acid Amides , Acta Chem. Scand. 2:1183, 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Dermatological Application of Mepivacaine (Carbocaine): A New Local Anesthetic

Download PDF
3 pages

Loading next page...
 
/lp/american-medical-association/dermatological-application-of-mepivacaine-carbocaine-a-new-local-TpKJN5dD4o

References (10)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1961.01580140071008
Publisher site
See Article on Publisher Site

Abstract

Abstract Research for more effective and less toxic local anesthetic agents has, over the years, brought to the physician new and valuable agents. One of the most recently introduced is mepivacaine (Carbocaine).* The purpose of this report is to present our initial clinical experience with this new anesthetic agent in a variety of dermatologic surgical procedures. We thought it of interest to include a brief discussion of some of the commonly employed local anesthetics. Brief History and Description of Local Anesthetics The discovery of cocaine by Nieman in 1860 and its first clinical application by Rotter in 1884 are outstanding landmarks. Equally important is the synthesis of procaine by Einhorn in 1905 and the publication of Regional Anesthesia by Labat in 1922. Following the synthesis of procaine, many other local anesthetic drugs have been developed. Procaine hydrochloride (Novocain) milligram for milligram is still one of the least toxic drugs. Tetracaine hydrochloride References 1. Carbocaine was supplied by the Medical Research Department of Winthrop Laboratories, New York. 2. Coakley, C. S.: Local Anesthesia , Postgrad. Med. 19:360, 1956. 3. Ekenstam, B. AF, and others: Trials with Carbocaine: A New Local Anaesthetic Drug , Brit. J. Anaesth. 28:503 ( (Nov.) ) 1956.Crossref 4. Dhunér, K. G.; Oljelund, O., and Aagesen, G.: Carbocaine-d, 1-N-Methyl-Pipecolic Acid 2, 6-Dimethylanilide: A New Local Anesthetic Agent , Acta chir. scand. 112:350 ( (May 3) ) 1957. 5. Dam, W., and Guldmann, N.: Carbocaine—a New Local Anaesthetic , Acta Anaesth. Scand. 1: 101 ( (Dec.) ) 1957.Crossref 6. Griesser, G.: Erfahrungen mit einem neuen Lokalanaestheticum , Anaesthesist 6:364 ( (Oct.) ) 1957. 7. Griesser, G.: Über ein neues Lokalanaesthetikum, Scandicain , Deut. Med. Wschr. 82:2071 ( (Dec. 6) ) 1957.Crossref 8. Erickson, J. C., III, and Hricke, M. J.: Clinical Evaluation of Mepivacaine, a New Local Anesthetic Agent , Guthrie Clin. Bull. , to be published. 9. Ulfendahl, H. R.: Some Pharmacological and Toxicological Properties of a New Local Anaesthetic, Carbocaine , Acta Anaesth. Scand. 1:81 ( (Dec.) ) 1957.Crossref 10. Luduena, F. P.; Hoppe, J. O.; Coulston, F., and Drobeck, H. P.: The Pharmacology and Toxicology of Mepivacaine, a New Local Anesthetic , Toxicol. & Appl. Pharmacol. 2:295 ( (May) ) 1960. 11. Ekenstam, B. AF; Egner, B., and Pettersson, G.: Local Anaesthetics: I. N-Alkylpyrrolidine and N-Alkyl Piperidine Carboxylic Acid Amides , Acta Chem. Scand. 2:1183, 1957.

Journal

Archives of Dermatology – American Medical Association

Published: Aug 1, 1961

There are no references for this article.