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Multiple Keratoacanthoma: Report of a Case Following the Administration of Mercurial Diuretics

Multiple Keratoacanthoma: Report of a Case Following the Administration of Mercurial Diuretics Abstract During the past few years an increasing interest in keratoacanthoma has been developing. The apparent rarity of the multiple self-healing epithelioma of Ferguson-Smith type has occasioned several recent case reports.1-4 Ephraim and Kaufman1 reported the 24th case in February, 1958. On the other hand, the so-called "solitary" or localized form of keratoacanthoma is not an unusual disorder. Recently, a patient came under my observation with multiple keratoacanthoma associated with an erythema multiforme type of dermatitis medicamentosa resulting from mercurial diuretics. A thorough search of the literature has revealed no previous cases of keratoacanthoma associated with either dermatitis medicamentosa or erythema multiforme. Report of Case On Oct. 7, 1957, a 78-year-old Caucasian woman of Anglo-Saxon descent was first observed in the Dermatology clinic of the Los Angeles County General Hospital because of an extensive eruption and was admitted to the hospital for treatment. Past History.— For the preceding two years she had been treated for congestive heart failure; previously, she had been in good health. Medication consisted of digitalis, meralluride sodium (Mercuhydrin, a parenteral mercurial diuretic), References 1. Ephraim, A. J., and Kaufman, J. J.: Multiple Keratoacanthoma: Report of an Extensive Case and Its Response to Therapy , A.M.A. Arch. Dermat. 77:191-194 ( (Feb.) ) 1958.Crossref 2. Epstein, N. N.; Biskind, G. R., and Pollock, R. S.: Multiple Primary Self-Healing Squamous-Cell "Epitheliomas" of the Skin , A.M.A. Arch. Dermat. 75:210-223 ( (Feb.) ) 1957.Crossref 3. Ereaux, L. P.; Schopflocher, P. L., and Fournier, C. J.: Keratoacanthoma , A.M.A. Arch. Dermat. 71:73-83 ( (Jan.) ) 1955.Crossref 4. Rook, A., and Moffat, J. L.: Multiple Self-Healing Epithelioma of the Ferguson-Smith Type: Report of Case of Unilateral Distribution , A.M.A. Arch. Dermat. 74:525-532 ( (Nov.) ) 1956.Crossref 5. Currie, A. R., and Smith, J. F.: Multiple Primary Spontaneous-Healing Squamous-Cell Carcinomata of the Skin , J. Path. & Bact. 64:827-839 ( (Oct.) ) 1952. 6. Smith, J. F.: A Case of Multiple Primary Squamous-Celled Carcinomata of the Skin in a Young Man with Spontaneous Healing , Brit. J. Dermat. 46:267-272 ( (June) ) 1934. 7. Poth, D. O.: Tumor-like Keratoses: Report of a Case , Arch. Dermat. & Syph. 39:228-238 ( (Feb.) ) 1939. 8. Bowman, H. E., and Pinkus, H.: Keratoacanthoma (Molluscum Sebaceum) , A.M.A. Arch. Path. 60:19-25 ( (July) ) 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Multiple Keratoacanthoma: Report of a Case Following the Administration of Mercurial Diuretics

A.M.A. Archives of Dermatology , Volume 81 (6) – Jun 1, 1960

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730060030005
Publisher site
See Article on Publisher Site

Abstract

Abstract During the past few years an increasing interest in keratoacanthoma has been developing. The apparent rarity of the multiple self-healing epithelioma of Ferguson-Smith type has occasioned several recent case reports.1-4 Ephraim and Kaufman1 reported the 24th case in February, 1958. On the other hand, the so-called "solitary" or localized form of keratoacanthoma is not an unusual disorder. Recently, a patient came under my observation with multiple keratoacanthoma associated with an erythema multiforme type of dermatitis medicamentosa resulting from mercurial diuretics. A thorough search of the literature has revealed no previous cases of keratoacanthoma associated with either dermatitis medicamentosa or erythema multiforme. Report of Case On Oct. 7, 1957, a 78-year-old Caucasian woman of Anglo-Saxon descent was first observed in the Dermatology clinic of the Los Angeles County General Hospital because of an extensive eruption and was admitted to the hospital for treatment. Past History.— For the preceding two years she had been treated for congestive heart failure; previously, she had been in good health. Medication consisted of digitalis, meralluride sodium (Mercuhydrin, a parenteral mercurial diuretic), References 1. Ephraim, A. J., and Kaufman, J. J.: Multiple Keratoacanthoma: Report of an Extensive Case and Its Response to Therapy , A.M.A. Arch. Dermat. 77:191-194 ( (Feb.) ) 1958.Crossref 2. Epstein, N. N.; Biskind, G. R., and Pollock, R. S.: Multiple Primary Self-Healing Squamous-Cell "Epitheliomas" of the Skin , A.M.A. Arch. Dermat. 75:210-223 ( (Feb.) ) 1957.Crossref 3. Ereaux, L. P.; Schopflocher, P. L., and Fournier, C. J.: Keratoacanthoma , A.M.A. Arch. Dermat. 71:73-83 ( (Jan.) ) 1955.Crossref 4. Rook, A., and Moffat, J. L.: Multiple Self-Healing Epithelioma of the Ferguson-Smith Type: Report of Case of Unilateral Distribution , A.M.A. Arch. Dermat. 74:525-532 ( (Nov.) ) 1956.Crossref 5. Currie, A. R., and Smith, J. F.: Multiple Primary Spontaneous-Healing Squamous-Cell Carcinomata of the Skin , J. Path. & Bact. 64:827-839 ( (Oct.) ) 1952. 6. Smith, J. F.: A Case of Multiple Primary Squamous-Celled Carcinomata of the Skin in a Young Man with Spontaneous Healing , Brit. J. Dermat. 46:267-272 ( (June) ) 1934. 7. Poth, D. O.: Tumor-like Keratoses: Report of a Case , Arch. Dermat. & Syph. 39:228-238 ( (Feb.) ) 1939. 8. Bowman, H. E., and Pinkus, H.: Keratoacanthoma (Molluscum Sebaceum) , A.M.A. Arch. Path. 60:19-25 ( (July) ) 1955.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1960

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