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Coccidioidal Granulomas of Skin and Conjunctiva Treated with Intravenous Amphotericin B: Report of a Case

Coccidioidal Granulomas of Skin and Conjunctiva Treated with Intravenous Amphotericin B: Report... Abstract In the treatment of deep mycotic infections, amphotericin B has been shown to have a wider spectrum of activity than other antifungal agents now available.1 However, the encouraging results reported in the treatment of other deep mycoses2,3 have not been uniformly obtained in the treatment of disseminated coccidioidomycosis.4 Because of the unusual occurrence of coccidioidal granulomas on the conjunctiva and the striking objective clinical and laboratory results obtained during an eightmonth period of treatment, the following case is reported. Report of Case In December, 1953, this 32-year-old Negro W.A.C. developed a group of nodules in the skin beneath the right breast two months after a trip through the San Joaquin Valley of California. The same month she was admitted to Letterman Army Hospital for surgical excision of the lesions, and a diagnosis of coccidioidomycosis was established histologically and by culture. She was returned to duty and remained References 1. Council on Drugs—New and Nonofficial Drugs—Amphotericin B (Fungizone) , J.A.M.A. 171:651-653 ( (Oct. 10) ) 1959.Crossref 2. Newcomer, V. D.; Sternberg, T. H.; Wright, E. T., and Reisner, R. M.: Current Status of Amphotericin B in the Treatment of Systemic Fungus Infections , J. Chronic Dis. 9:353-374 ( (April) ) 1959.Crossref 3. Littman, M. L.; Horowitz, P. L., and Swadey, J. G.: Coccidioidomycosis and Its Treatment with Amphotericin B , Am. J. Med. 24:568-592 ( (April) ) 1958.Crossref 4. Utz, J. P.; Treger, A.; McCullough, N. B., and Emmons, C. W.: Amphotericin B: Intravenous 5. Use in 21 Patients with Systemic Fungal Diseases , Antibiotics Ann. , pp. 628-634, 1958-1959. 6. Castellot, J. J.; Pitts, F. W., and Mowrey, F. H.: A Case of Coccidioidal Meningitis Arrested by Prolonged Therapy with Intravenous Amphotericin B , Antibiotic Med. 6:480-485 ( (Aug.) ) 1959. 7. Smith, C. E.; Saito, M. T., and Simons, S. A.: Pattern of 39,500 Serologic Tests in Coccidioidomycosis , J.A.M.A. 160:546-552 ( (Feb. 18) ) 1956.Crossref 8. Anderson, B.; Roberts, S. S., Jr.; Gonzalez, C., and Chick, E. W.: Mycotic Ulcerative Keratitis , A.M.A. Arch. Ophth. 62:169-179 ( (Aug.) ) 1959.Crossref 9. Foster, J. B.; Almeda, E.; Littman, M. L., and Wilson, M. E.: Some Intraocular and Conjunctival Effects of Amphotericin B in Man and in the Rabbit , A.M.A. Arch. Ophth. 60:555-564 ( (Oct.) ) 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Coccidioidal Granulomas of Skin and Conjunctiva Treated with Intravenous Amphotericin B: Report of a Case

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1960.01580040123021
Publisher site
See Article on Publisher Site

Abstract

Abstract In the treatment of deep mycotic infections, amphotericin B has been shown to have a wider spectrum of activity than other antifungal agents now available.1 However, the encouraging results reported in the treatment of other deep mycoses2,3 have not been uniformly obtained in the treatment of disseminated coccidioidomycosis.4 Because of the unusual occurrence of coccidioidal granulomas on the conjunctiva and the striking objective clinical and laboratory results obtained during an eightmonth period of treatment, the following case is reported. Report of Case In December, 1953, this 32-year-old Negro W.A.C. developed a group of nodules in the skin beneath the right breast two months after a trip through the San Joaquin Valley of California. The same month she was admitted to Letterman Army Hospital for surgical excision of the lesions, and a diagnosis of coccidioidomycosis was established histologically and by culture. She was returned to duty and remained References 1. Council on Drugs—New and Nonofficial Drugs—Amphotericin B (Fungizone) , J.A.M.A. 171:651-653 ( (Oct. 10) ) 1959.Crossref 2. Newcomer, V. D.; Sternberg, T. H.; Wright, E. T., and Reisner, R. M.: Current Status of Amphotericin B in the Treatment of Systemic Fungus Infections , J. Chronic Dis. 9:353-374 ( (April) ) 1959.Crossref 3. Littman, M. L.; Horowitz, P. L., and Swadey, J. G.: Coccidioidomycosis and Its Treatment with Amphotericin B , Am. J. Med. 24:568-592 ( (April) ) 1958.Crossref 4. Utz, J. P.; Treger, A.; McCullough, N. B., and Emmons, C. W.: Amphotericin B: Intravenous 5. Use in 21 Patients with Systemic Fungal Diseases , Antibiotics Ann. , pp. 628-634, 1958-1959. 6. Castellot, J. J.; Pitts, F. W., and Mowrey, F. H.: A Case of Coccidioidal Meningitis Arrested by Prolonged Therapy with Intravenous Amphotericin B , Antibiotic Med. 6:480-485 ( (Aug.) ) 1959. 7. Smith, C. E.; Saito, M. T., and Simons, S. A.: Pattern of 39,500 Serologic Tests in Coccidioidomycosis , J.A.M.A. 160:546-552 ( (Feb. 18) ) 1956.Crossref 8. Anderson, B.; Roberts, S. S., Jr.; Gonzalez, C., and Chick, E. W.: Mycotic Ulcerative Keratitis , A.M.A. Arch. Ophth. 62:169-179 ( (Aug.) ) 1959.Crossref 9. Foster, J. B.; Almeda, E.; Littman, M. L., and Wilson, M. E.: Some Intraocular and Conjunctival Effects of Amphotericin B in Man and in the Rabbit , A.M.A. Arch. Ophth. 60:555-564 ( (Oct.) ) 1958.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Oct 1, 1960

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