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Zirconium Granulomas of the Glabrous Skin Following Treatment of Rhus Dermatitis: Report of Two Cases

Zirconium Granulomas of the Glabrous Skin Following Treatment of Rhus Dermatitis: Report of Two... Abstract Since the fall of 1956,1 granulomas of the axillae following the use of a stick type deodorant containing sodium zirconium lactate have been reported in increasing numbers. Their location has been invariably confined to the axillae, and they appear as reddish-brown discrete papules, 1 to 4 mm. in diameter. Shelley and Hurley2 have recently reviewed 64 cases previously reported and added 6 of their own. To date, there has been no evidence of skin reactions following the use of the insoluble hydrous zirconium oxide which has long been used in large quantities for treatment of Rhus dermatitis.3 The following report consists of two additional patients with zirconium granulomas, one of which occurred on the glabrous surfaces of both forearms and neck after repeated applications of hydrous zirconium oxide over an 18-month period. Report of Cases Case 1.—A 50-year-old Caucasian woman was treated References 1. Rubin, L.; Slepyan, A. H.; Weber, L. F., and Neuhauser, I.: Granulomas of the Axillae Caused by Deodorants , J. A. M. A. 162:953 ( (Nov. 3) ) 1956.Crossref 2. Shelley, W. B., and Hurley, H. J.: The Allergic Origin of Zirconium Deodorant Granulomas , Brit. J. Dermat. 70:75 ( (March) ) 1958.Crossref 3. Cronk, G. A.: Zirconium Salts in Prevention and Treatment of Rhus Toxicodendron Dermatitis , A. M. A. Arch. Dermat. & Syph. 66:282 ( (Aug.) ) 1952. 4. Harding, H. E.: Toxicology of Zirconium: Preliminary Report , Brit. J. Indust. Med. 5:75 ( (April) ) 1948. 5. Sheard, C., Jr.; Cormia, F. E.; Atkinson, S. C., and Worthington, E. L.: Granulomatous Reactions to Deodorant Sticks , J. A. M. A. 164:1085 ( (July 6) ) 1957. 6. Caspers, A. P.: Poison Ivy (Rhus Toxicodendron): A Survey of the Poison Ivy Problem in Canada and Some Independent Observations on the Value of Zirconium Products in Prophylaxis and Treatment , Canad. M. A. J. 76:852 ( (May) ) 1957. 7. Blumenthal, W.: Some Properties of Zirconium Compounds Significant to the Cosmetic Technologist , J. Soc. Cosmetic Chemists 4:69 ( (Aug.) ) 1953. 8. Prior, J. T.; Rustad, H., and Cronk, G. H.: Pathological Changes Associated with Deodorant Preparations Containing Sodium Zirconium Lactates: An Experimental Study , J. Invest. Dermat. 29:449 ( (Dec.) ) 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Zirconium Granulomas of the Glabrous Skin Following Treatment of Rhus Dermatitis: Report of Two Cases

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560210015003
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Abstract

Abstract Since the fall of 1956,1 granulomas of the axillae following the use of a stick type deodorant containing sodium zirconium lactate have been reported in increasing numbers. Their location has been invariably confined to the axillae, and they appear as reddish-brown discrete papules, 1 to 4 mm. in diameter. Shelley and Hurley2 have recently reviewed 64 cases previously reported and added 6 of their own. To date, there has been no evidence of skin reactions following the use of the insoluble hydrous zirconium oxide which has long been used in large quantities for treatment of Rhus dermatitis.3 The following report consists of two additional patients with zirconium granulomas, one of which occurred on the glabrous surfaces of both forearms and neck after repeated applications of hydrous zirconium oxide over an 18-month period. Report of Cases Case 1.—A 50-year-old Caucasian woman was treated References 1. Rubin, L.; Slepyan, A. H.; Weber, L. F., and Neuhauser, I.: Granulomas of the Axillae Caused by Deodorants , J. A. M. A. 162:953 ( (Nov. 3) ) 1956.Crossref 2. Shelley, W. B., and Hurley, H. J.: The Allergic Origin of Zirconium Deodorant Granulomas , Brit. J. Dermat. 70:75 ( (March) ) 1958.Crossref 3. Cronk, G. A.: Zirconium Salts in Prevention and Treatment of Rhus Toxicodendron Dermatitis , A. M. A. Arch. Dermat. & Syph. 66:282 ( (Aug.) ) 1952. 4. Harding, H. E.: Toxicology of Zirconium: Preliminary Report , Brit. J. Indust. Med. 5:75 ( (April) ) 1948. 5. Sheard, C., Jr.; Cormia, F. E.; Atkinson, S. C., and Worthington, E. L.: Granulomatous Reactions to Deodorant Sticks , J. A. M. A. 164:1085 ( (July 6) ) 1957. 6. Caspers, A. P.: Poison Ivy (Rhus Toxicodendron): A Survey of the Poison Ivy Problem in Canada and Some Independent Observations on the Value of Zirconium Products in Prophylaxis and Treatment , Canad. M. A. J. 76:852 ( (May) ) 1957. 7. Blumenthal, W.: Some Properties of Zirconium Compounds Significant to the Cosmetic Technologist , J. Soc. Cosmetic Chemists 4:69 ( (Aug.) ) 1953. 8. Prior, J. T.; Rustad, H., and Cronk, G. H.: Pathological Changes Associated with Deodorant Preparations Containing Sodium Zirconium Lactates: An Experimental Study , J. Invest. Dermat. 29:449 ( (Dec.) ) 1957.

Journal

A.M.A. Archives of Dermatology – American Medical Association

Published: Sep 1, 1959

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