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The Reduction of Gonadal Dose in Dermatologic Radiotherapy

The Reduction of Gonadal Dose in Dermatologic Radiotherapy Abstract There is a need for more definite information regarding the rate of genetic mutations occurring in man and the sensitivity to ionizing radiations. Although genetic mutations may occur spontaneously, there are several factors that are known to increase the rate of mutations. Ultraviolet light and heat are two of these. Recently Ehrenberg et al.1 showed that today's mode of dress for men increases the testicular temperature. They found a difference of at least 3 C between clothed and disrobed states. They also postulated that almost half of the present load of spontaneous mutations might be due to the mode of dress for the past two centuries. Further, the heat factor might imply genetical hazards 100-1,000 times greater than those estimated from various sources of ionizing radiation. Ionizing radiation can produce genetic mutations, and there is no threshold dose for ionizing radiation below which mutations References 1. Ehrenberg, L.; von Ehrenstein, G., and Hedgren, A.: Gonad Temperature and Spontaneous Mutation-Rate in Man , Nature, London 180:1433-1434 ( (Dec. 21) ) 1957.Crossref 2. Glass, B.: The Genetic Basis for the Limitation of Radiation Exposure , Am. J. Roentgenol. 78:955-960 ( (Dec.) ) 1957. 3. Garland, L. H.: Paper, read at 10th Mid-Winter Conference of Los Angeles Radiological Society, March, 1958. 4. Laughlin, J. S., and Pullman, I.: Gonadal Dose Produced by Medical Use of X-Rays: Preliminary Edition , prepared for Genetics Committee, of National Academy of Sciences' Study of the Biological Effects of Atomic Radiation, 1957. 5. The Biological Effects of Atomic Radiation , National Academy of Sciences, 1956, p. 21. 6. Laughlin, J. S., Meurk, M. L., Pullman, I., and Sherman, R. S.: Bone, Skin, and Gonadal Doses in Routine Diagnostic Procedures , Am. J. Roentgenol. 78:961-982 ( (Dec.) ) 1957. 7. Hodges, P. C.: Health Hazards in the Diagnostic Use of X-Ray , J. A. M. A. 166:577-584 ( (Feb. 8) ) 1958.Crossref 8. Witten, V. H.; Sulzberger, M. B., and Stewart, W. D.: Studies on the Quantity of Radiation Reaching the Gonadal Areas During Dermatologic X-Ray Therapy , A. M. A. Arch. Dermat. 76:683-694 ( (Dec.) ) 1957.Crossref 9. Glasser, O.; Quimby, E. H.; Taylor, L. S., and Weatherwax, J. L.: Physical Foundations of Radiology , Ed. 2, New York, Paul B. Hoeber, Inc., 1952, p. 449. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

The Reduction of Gonadal Dose in Dermatologic Radiotherapy

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560160067008
Publisher site
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Abstract

Abstract There is a need for more definite information regarding the rate of genetic mutations occurring in man and the sensitivity to ionizing radiations. Although genetic mutations may occur spontaneously, there are several factors that are known to increase the rate of mutations. Ultraviolet light and heat are two of these. Recently Ehrenberg et al.1 showed that today's mode of dress for men increases the testicular temperature. They found a difference of at least 3 C between clothed and disrobed states. They also postulated that almost half of the present load of spontaneous mutations might be due to the mode of dress for the past two centuries. Further, the heat factor might imply genetical hazards 100-1,000 times greater than those estimated from various sources of ionizing radiation. Ionizing radiation can produce genetic mutations, and there is no threshold dose for ionizing radiation below which mutations References 1. Ehrenberg, L.; von Ehrenstein, G., and Hedgren, A.: Gonad Temperature and Spontaneous Mutation-Rate in Man , Nature, London 180:1433-1434 ( (Dec. 21) ) 1957.Crossref 2. Glass, B.: The Genetic Basis for the Limitation of Radiation Exposure , Am. J. Roentgenol. 78:955-960 ( (Dec.) ) 1957. 3. Garland, L. H.: Paper, read at 10th Mid-Winter Conference of Los Angeles Radiological Society, March, 1958. 4. Laughlin, J. S., and Pullman, I.: Gonadal Dose Produced by Medical Use of X-Rays: Preliminary Edition , prepared for Genetics Committee, of National Academy of Sciences' Study of the Biological Effects of Atomic Radiation, 1957. 5. The Biological Effects of Atomic Radiation , National Academy of Sciences, 1956, p. 21. 6. Laughlin, J. S., Meurk, M. L., Pullman, I., and Sherman, R. S.: Bone, Skin, and Gonadal Doses in Routine Diagnostic Procedures , Am. J. Roentgenol. 78:961-982 ( (Dec.) ) 1957. 7. Hodges, P. C.: Health Hazards in the Diagnostic Use of X-Ray , J. A. M. A. 166:577-584 ( (Feb. 8) ) 1958.Crossref 8. Witten, V. H.; Sulzberger, M. B., and Stewart, W. D.: Studies on the Quantity of Radiation Reaching the Gonadal Areas During Dermatologic X-Ray Therapy , A. M. A. Arch. Dermat. 76:683-694 ( (Dec.) ) 1957.Crossref 9. Glasser, O.; Quimby, E. H.; Taylor, L. S., and Weatherwax, J. L.: Physical Foundations of Radiology , Ed. 2, New York, Paul B. Hoeber, Inc., 1952, p. 449.

Journal

A.M.A. Archives of Dermatology – American Medical Association

Published: Apr 1, 1959

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