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Fungous Infections of the Skin Treated with Pyrrobutamine Compounds

Fungous Infections of the Skin Treated with Pyrrobutamine Compounds Abstract The in vitro fungistatic activity of certain antihistamine drugs has been previously recorded. Apparently there is considerable variation among different members of this group of agents in this regard. Some are altogether incapable of inhibiting fungi, whereas others possess this characteristic in varying degree. Carson and Campbell1 demonstrated the in vitro fungistatic activity against several species of pathogenic fungi (Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton ferrugineum, Microsporum gypseum, Microsporum canis and Epidermophyton floccosum) of diphenylpyraline, antazoline (Antistine), and tripelennamine (Pyribenzamine). Concentrations as low as 0.1 mg/ml. were capable of restricting the growth of some of the organisms, but higher levels of more than 1 mg/ml. were required for complete suppression of certain fungi. Carson and Campbell found that the fungistatic effect of the drugs tested could be reduced or abolished in media adjusted to pH 5 and that for tripelennamine there was an References 1. The drugs were incorporated into dextrosesabouraud's agar (Difco) making final concentrations varying from 10 to 1000 μg. per milliliter of medium. 2. Supplied by M. H. Mothersill, M.D., The Lilly Research Laboratories, Indianapolis, Ind. 3. Carson, L. E., and Campbell, C. C.: The Inhibitory Effect of Three Antihistaminic Compounds on the Growth of Fungi Pathogenic for Man , Science 111:689-691, 1950.Crossref 4. Mothersill, M. H.: Mills, J.; Lee, H.; Anderson, R., and Harris, P.: Chemical and Pharmacological Characteristics of the Antihistaminic Compound, Pyrrobutamine , Ann. Allergy 11:754-757, 1953. 5. Fahlberg W. J.: In Vitro Studies of the Fungistatic Effect of Antihistaminic Drugs , J. Invest. Dermat. 20:171-176, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Fungous Infections of the Skin Treated with Pyrrobutamine Compounds

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1957.01550240101022
Publisher site
See Article on Publisher Site

Abstract

Abstract The in vitro fungistatic activity of certain antihistamine drugs has been previously recorded. Apparently there is considerable variation among different members of this group of agents in this regard. Some are altogether incapable of inhibiting fungi, whereas others possess this characteristic in varying degree. Carson and Campbell1 demonstrated the in vitro fungistatic activity against several species of pathogenic fungi (Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton ferrugineum, Microsporum gypseum, Microsporum canis and Epidermophyton floccosum) of diphenylpyraline, antazoline (Antistine), and tripelennamine (Pyribenzamine). Concentrations as low as 0.1 mg/ml. were capable of restricting the growth of some of the organisms, but higher levels of more than 1 mg/ml. were required for complete suppression of certain fungi. Carson and Campbell found that the fungistatic effect of the drugs tested could be reduced or abolished in media adjusted to pH 5 and that for tripelennamine there was an References 1. The drugs were incorporated into dextrosesabouraud's agar (Difco) making final concentrations varying from 10 to 1000 μg. per milliliter of medium. 2. Supplied by M. H. Mothersill, M.D., The Lilly Research Laboratories, Indianapolis, Ind. 3. Carson, L. E., and Campbell, C. C.: The Inhibitory Effect of Three Antihistaminic Compounds on the Growth of Fungi Pathogenic for Man , Science 111:689-691, 1950.Crossref 4. Mothersill, M. H.: Mills, J.; Lee, H.; Anderson, R., and Harris, P.: Chemical and Pharmacological Characteristics of the Antihistaminic Compound, Pyrrobutamine , Ann. Allergy 11:754-757, 1953. 5. Fahlberg W. J.: In Vitro Studies of the Fungistatic Effect of Antihistaminic Drugs , J. Invest. Dermat. 20:171-176, 1953.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1957

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