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Exfoliative Dermatitis Associated with Hypogammaglobulinemia

Exfoliative Dermatitis Associated with Hypogammaglobulinemia Abstract In 1952, Bruton,1 introduced the term ``agammaglobulinemia'' to describe a new syndrome in an 8-year-old boy, who from the age of 3½ years had had multiple attacks of respiratory and blood-stream infections, often with the same micro-organism. This patient was found to be unable to develop circulating antibodies to a series of injected antigens, and electrophoretic analysis of his plasma disclosed an almost complete absence of γ-globulin. Since that time more than 30 comparable cases have been observed in children here and abroad. Inasmuch as these patients were all boys, the defect has been considered to be genetically determined as a sex-linked recessive. These children characteristically suffer from an early age with recurrent severe infections due to the common pyogenic bacteria. Such infections include pyoderma, purulent conjunctivitis, otitis media, purulent sinusitis, pneumonia, meningitis, and purulent arthritis. Administration of appropriate antibiotics often controls these infections, References 1. References 4 to 7. 2. Bruton, O. C.: Agammaglobulinemia , Pediatrics 9:722, 1952. 3. Craig, J. M.; Gitlin, D., and Jewett, T. C.: Response of Lymph Nodes of Normal Children and Congenitally Agammaglobulinemic Children to Antigenic Stimulation , A. M. A. Am. J. Dis. Child. 88:626, 1954. 4. Zinneman, H. H.; Hall, W. H., and Heller, B. I.: Acquired Agammaglobulinemia , J.A.M.A. 156:1390, 1954.Crossref 5. Janeway, C. A.; Apt, L., and Gitlin, D.: Agammaglobulinemia , Tr. A. Am. Physicians 66:200, 1953. 6. Keidan, S. E.; McCarthy, K., and Haworth, J. C.: Fatal Generalized Vaccinia with Failure of Antibody Production and Absence of Serum Gamma Globulin , Arch. Dis. Childhood 28:110, 1953.Crossref 7. Chappell, A. K.: Agammaglobulinemia: Report of a Case and Review of the Literature , J. Iowa M. Soc. 45:132, 1955. 8. Marcussen, P. V.: Hypogammaglobulinemia in Pyoderma Gangrenosum , J. Invest. Dermat. 24:275, 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Exfoliative Dermatitis Associated with Hypogammaglobulinemia

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550100001001
Publisher site
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Abstract

Abstract In 1952, Bruton,1 introduced the term ``agammaglobulinemia'' to describe a new syndrome in an 8-year-old boy, who from the age of 3½ years had had multiple attacks of respiratory and blood-stream infections, often with the same micro-organism. This patient was found to be unable to develop circulating antibodies to a series of injected antigens, and electrophoretic analysis of his plasma disclosed an almost complete absence of γ-globulin. Since that time more than 30 comparable cases have been observed in children here and abroad. Inasmuch as these patients were all boys, the defect has been considered to be genetically determined as a sex-linked recessive. These children characteristically suffer from an early age with recurrent severe infections due to the common pyogenic bacteria. Such infections include pyoderma, purulent conjunctivitis, otitis media, purulent sinusitis, pneumonia, meningitis, and purulent arthritis. Administration of appropriate antibiotics often controls these infections, References 1. References 4 to 7. 2. Bruton, O. C.: Agammaglobulinemia , Pediatrics 9:722, 1952. 3. Craig, J. M.; Gitlin, D., and Jewett, T. C.: Response of Lymph Nodes of Normal Children and Congenitally Agammaglobulinemic Children to Antigenic Stimulation , A. M. A. Am. J. Dis. Child. 88:626, 1954. 4. Zinneman, H. H.; Hall, W. H., and Heller, B. I.: Acquired Agammaglobulinemia , J.A.M.A. 156:1390, 1954.Crossref 5. Janeway, C. A.; Apt, L., and Gitlin, D.: Agammaglobulinemia , Tr. A. Am. Physicians 66:200, 1953. 6. Keidan, S. E.; McCarthy, K., and Haworth, J. C.: Fatal Generalized Vaccinia with Failure of Antibody Production and Absence of Serum Gamma Globulin , Arch. Dis. Childhood 28:110, 1953.Crossref 7. Chappell, A. K.: Agammaglobulinemia: Report of a Case and Review of the Literature , J. Iowa M. Soc. 45:132, 1955. 8. Marcussen, P. V.: Hypogammaglobulinemia in Pyoderma Gangrenosum , J. Invest. Dermat. 24:275, 1955.Crossref

Journal

A.M.A. Archives of Dermatology – American Medical Association

Published: Oct 1, 1956

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