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The Clinical Significance of the L. E. Clot Test

The Clinical Significance of the L. E. Clot Test Abstract It is generally agreed that the demonstration of L. E. cells in the bone marrow or blood is a highly specific test for systemic lupus erythematosus. Aside from its value in diagnosis, the test is proving useful to the clinician in broadening his understanding of many hitherto puzzling features of the natural history of the disease, its often protracted and variable course, as well as its protean symptomatology. One of the most satisfactory laboratory procedures for the demonstration of L. E. cells is by means of the two-hour clot technique on peripheral blood. This so-called L. E. clot test has been in use in the laboratories of the Mayo Clinic since the fall of 1951 as a screening procedure in cases in which the clinician had some reason to suspect the presence of lupus erythematosus. In order to evaluate the L. E. clot test more References 1. References 6 to 9. 2. Hargraves, M. M.; Richmond, H., and Morton, R.: Presentation of Two Bone Marrow Elements: The "Tart" Cell and the "L. E." Cell , Proc. Staff Meet. Mayo Clin. 23:25-28 ( (Jan. 21) ) 1948. 3. Zimmer, F. E., and Hargraves, M. M.: The Effect of Blood Coagulation on L. E. Cell Formation , Proc. Staff Meet. Mayo Clin. 27:424-430 ( (Oct. 22) ) 1952. 4. Lee, S. L.: A Simple Test for L. E. Cells , Am. J. Clin. Path. 21:492-496 ( (May) ) 1951. 5. Haserick, J. R.; Lewis, L. A., and Bortz, D. W.: Blood Factor in Acute Disseminated Lupus Erythematosus: I. Determination of Gamma Globulin as Specific Plasma Fraction , Am. J. M. Sc. 219:660-663 ( (June) ) 1950.Crossref 6. Magath, T. B., and Winkle, V.: Technic for Demonstrating "L. E." (Lupus Erythematosus) Cells in Blood , Am. J. Clin. Path. 22:586-587 ( (June) ) 1952. 7. Dubois, E. L.: The Effect of the L. E. Cell Test on the Clinical Picture of Systemic Lupus Erythematosus , Ann. Int. Med. 38:1265-1294 ( (June) ) 1953.Crossref 8. Ross, S. W., and Wells, B. B.: Systemic Lupus Erythematosus: A Review of the Literature , Am. J. Clin. Path. 23:139-160 ( (Feb.) ) 1953. 9. Harvey, A. M.; Shulman, L. E.; Tumulty, P. A.; Conley, C. L., and Shoenrich, E. H.: Systemic Lupus Erythematosus: Review of the Literature and Clinical Analysis of 138 Cases , Medicine 33:291-437 ( (Dec.) ) 1954.Crossref 10. Weiss, R. S., and Swift, S.: The Significance of a Positive L. E. Phenomenon , A. M. A. Arch. Dermat. 72:103-112 ( (Aug.) ) 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550040001001
Publisher site
See Article on Publisher Site

Abstract

Abstract It is generally agreed that the demonstration of L. E. cells in the bone marrow or blood is a highly specific test for systemic lupus erythematosus. Aside from its value in diagnosis, the test is proving useful to the clinician in broadening his understanding of many hitherto puzzling features of the natural history of the disease, its often protracted and variable course, as well as its protean symptomatology. One of the most satisfactory laboratory procedures for the demonstration of L. E. cells is by means of the two-hour clot technique on peripheral blood. This so-called L. E. clot test has been in use in the laboratories of the Mayo Clinic since the fall of 1951 as a screening procedure in cases in which the clinician had some reason to suspect the presence of lupus erythematosus. In order to evaluate the L. E. clot test more References 1. References 6 to 9. 2. Hargraves, M. M.; Richmond, H., and Morton, R.: Presentation of Two Bone Marrow Elements: The "Tart" Cell and the "L. E." Cell , Proc. Staff Meet. Mayo Clin. 23:25-28 ( (Jan. 21) ) 1948. 3. Zimmer, F. E., and Hargraves, M. M.: The Effect of Blood Coagulation on L. E. Cell Formation , Proc. Staff Meet. Mayo Clin. 27:424-430 ( (Oct. 22) ) 1952. 4. Lee, S. L.: A Simple Test for L. E. Cells , Am. J. Clin. Path. 21:492-496 ( (May) ) 1951. 5. Haserick, J. R.; Lewis, L. A., and Bortz, D. W.: Blood Factor in Acute Disseminated Lupus Erythematosus: I. Determination of Gamma Globulin as Specific Plasma Fraction , Am. J. M. Sc. 219:660-663 ( (June) ) 1950.Crossref 6. Magath, T. B., and Winkle, V.: Technic for Demonstrating "L. E." (Lupus Erythematosus) Cells in Blood , Am. J. Clin. Path. 22:586-587 ( (June) ) 1952. 7. Dubois, E. L.: The Effect of the L. E. Cell Test on the Clinical Picture of Systemic Lupus Erythematosus , Ann. Int. Med. 38:1265-1294 ( (June) ) 1953.Crossref 8. Ross, S. W., and Wells, B. B.: Systemic Lupus Erythematosus: A Review of the Literature , Am. J. Clin. Path. 23:139-160 ( (Feb.) ) 1953. 9. Harvey, A. M.; Shulman, L. E.; Tumulty, P. A.; Conley, C. L., and Shoenrich, E. H.: Systemic Lupus Erythematosus: Review of the Literature and Clinical Analysis of 138 Cases , Medicine 33:291-437 ( (Dec.) ) 1954.Crossref 10. Weiss, R. S., and Swift, S.: The Significance of a Positive L. E. Phenomenon , A. M. A. Arch. Dermat. 72:103-112 ( (Aug.) ) 1955.Crossref

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1956

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