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CLINICAL EVALUATION OF FIVE-TENTHS PER CENT HYDROCORTISONE OINTMENT

CLINICAL EVALUATION OF FIVE-TENTHS PER CENT HYDROCORTISONE OINTMENT Abstract Hydrocortisone has now been established as an effective medication for topical use in many dermatologic conditions.* Most investigators have reported on the value of a 1% concentration of hydrocortisone acetate and have stated that concentrations below 1% were of no value.† It has recently been shown,‡ however, that the free alcohol of hydrocortisone is more effective topically than the hydrocortisone acetate. Accordingly, an ointment containing a concentration of a 0.5% hydrocortisone free alcohol was clinically evaluated and compared with the same ointment in a 1% concentration. Our results showed that a 0.5% hydrocortisone free alcohol ointment is a useful and effective medication topically. METHODS AND MATERIALS Two hundred eighty-two patients were treated with two ointments containing a concentration of 0.5% hydrocortisone free alcohol and 1% hydrocortisone free alcohol. Wherever possible, contralateral areas were treated with each ointment for comparative evaluation. References 1. References 1, 2, and 3. 2. References 2 and 4. 3. References 3 and 5. 4. Sulzberger, M. B., and Witten, V. H.: Hydrocortisone (Compound F) Acetate Ointment in Dermatological Therapy , J. A. M. A. 151:468, ( (Feb. 7) ) 1953. 5. Robinson, H. M., Jr., and Robinson, R. C. V.: Treatment of Dermatoses with Local Application of Hydrocortisone Acetate , J. A. M. A. 155:1213 ( (July 31) ) 1954.Crossref 6. Frank, L.; Stritzler, C., and Kaufman, J.: Hydrocortisone (Compound F) Free Alcohol and Hydrocortisone Acetate for Topical Use , A. M. A. Arch. Dermat. 71:117 ( (Jan.) ) 1955.Crossref 7. Heilson, B.; Kristjansen, A., and Reymann, F.: Hydrocortisone in Therapy of Cutaneous Disease , A. M. A. Arch. Dermat. & Syph. 70:360 ( (Sept.) ) 1954. 8. Sulzberger, M. B.; Witten, V. H., and Smith, C. C.: Hydrocortisone (Compound F) Free Alcohol Ointment, Correspondence , J. A. M. A. 152:1456 ( (Aug. 8) ) 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

CLINICAL EVALUATION OF FIVE-TENTHS PER CENT HYDROCORTISONE OINTMENT

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1955.01540290077020
Publisher site
See Article on Publisher Site

Abstract

Abstract Hydrocortisone has now been established as an effective medication for topical use in many dermatologic conditions.* Most investigators have reported on the value of a 1% concentration of hydrocortisone acetate and have stated that concentrations below 1% were of no value.† It has recently been shown,‡ however, that the free alcohol of hydrocortisone is more effective topically than the hydrocortisone acetate. Accordingly, an ointment containing a concentration of a 0.5% hydrocortisone free alcohol was clinically evaluated and compared with the same ointment in a 1% concentration. Our results showed that a 0.5% hydrocortisone free alcohol ointment is a useful and effective medication topically. METHODS AND MATERIALS Two hundred eighty-two patients were treated with two ointments containing a concentration of 0.5% hydrocortisone free alcohol and 1% hydrocortisone free alcohol. Wherever possible, contralateral areas were treated with each ointment for comparative evaluation. References 1. References 1, 2, and 3. 2. References 2 and 4. 3. References 3 and 5. 4. Sulzberger, M. B., and Witten, V. H.: Hydrocortisone (Compound F) Acetate Ointment in Dermatological Therapy , J. A. M. A. 151:468, ( (Feb. 7) ) 1953. 5. Robinson, H. M., Jr., and Robinson, R. C. V.: Treatment of Dermatoses with Local Application of Hydrocortisone Acetate , J. A. M. A. 155:1213 ( (July 31) ) 1954.Crossref 6. Frank, L.; Stritzler, C., and Kaufman, J.: Hydrocortisone (Compound F) Free Alcohol and Hydrocortisone Acetate for Topical Use , A. M. A. Arch. Dermat. 71:117 ( (Jan.) ) 1955.Crossref 7. Heilson, B.; Kristjansen, A., and Reymann, F.: Hydrocortisone in Therapy of Cutaneous Disease , A. M. A. Arch. Dermat. & Syph. 70:360 ( (Sept.) ) 1954. 8. Sulzberger, M. B.; Witten, V. H., and Smith, C. C.: Hydrocortisone (Compound F) Free Alcohol Ointment, Correspondence , J. A. M. A. 152:1456 ( (Aug. 8) ) 1953.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: May 1, 1955

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