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HISTOPATHOLOGIC CORRELATION OF LESIONS OF PAPULAR URTICARIA AND POSITIVE SKIN TEST REACTIONS TO INSECT ANTIGENS

HISTOPATHOLOGIC CORRELATION OF LESIONS OF PAPULAR URTICARIA AND POSITIVE SKIN TEST REACTIONS TO... Abstract A SUBSTANTIAL body of evidence indicates that many cases of papular urticaria are related to insect bite sensitivity.* This opinion is based, in part, on the fact that the patients with papular urticaria give positive delayed (tuberculin type) skin test reactions to the intradermal injection of insect antigen. (Figs. 1, 2, and 3). In an effort to determine the validity of this etiologic concept, we have examined a number of lesions of papular urticaria histologically and have compared these findings with those of positive urticarial and delayed tuberculin-type skin reactions to insect antigen, and with ordinary insect bites. These studies have shown a striking similarity of such lesions. METHOD OF STUDY Patients with papular urticaria were given intracutaneous injections of mosquito (Culex pipiens) flea, (Ctenocephalides felis), and bedbug (Cimex lectularius) antigens. These antigens were prepared after the method of Cherney and co-workers14; 0.1 cc. of 1: 5,000 References 1. References 1 to 13. 2. References 1 and 2. 3. Shaffer, B.; Spencer, M. C., and Blank, H.: Papular Urticaria; Its Response to Treatment with DDT and the Role of Insect Bites in Its Etiology , J. Invest. Dermat. 2:293, 1948.Crossref 4. Blank, H.; Shaffer, B.; Spencer, M. C., and March, W. C.: Papular Urticaria; Study of the Role of Insect in Its Etiology and the Use of DDT in Its Treatment , Pediatrics 5:408, 1950. 5. Shaffer, B.; Jacobson, C., and Beerman, H.: Papular Urticaria, Its Relationship to Insect Allergy , Ann. Allergy 10:411, 1952. 6. Chipman, E. D.: Urticaria, with Special Reference to the Cause in Papular Forms of Children , California Med. 8:207, 1910. 7. Dietrich, A.: Hautreaktionen nach Ungezieferbissen , Monatsschr. Kinderh. 75:70, 1938. 8. Dietrich, A.: Hautreaktionen nach Ungezieferstichen unter dem Bild eines Lichen urticatus , Arch. Dermat. u. Syph. 182:668, 1942.Crossref 9. Hamburger, F.: Lichen urticatus durch Ungeziefer: Reply to Pfaundler , München. med. Wchnschr. 89:652, 1942. 10. Lunsford, C. J.: Flea Problem in California , Arch. Dermat. & Syph. 60:1184, 1949. 11. Goldman, L.: Lichen Urticatus Syndrome as a Manifestation of Sensitivity to Bites from Various Species of Anthropods , Arch. Dermat. & Syph. , 58:74, 1948. 12. Bowen, R.: Insects and Allergic Problems , South. M. J. 44:838, 1951. 13. Fuchs, H.: Urticaria papulosa durch Stiche von Scleroderma domestica , Dermatologica 105:213, 1952. 14. Harant, H., and Huttel, W.: Un insecte vulnérant peu connu , Bull. Soc. path. exot. 43:449, 1950. 15. Rook, A., and Frain-Bell, W.: Papular Urticaria , Arch. Dis. Childhood 28:304, 1953. 16. Cherney, L. S.; Wheeler, C. M., and Reed, A. C.: Flea Antigen in Prevention of Flea Bites , Am. J. Trop. Med. 19:327, 1939. 17. Goldman, L.; Rockwell, E., and Richfield, D. F.: III. Histopathological Studies on Cutaneous Reactions to Bites of Various Arthropods , Am. J. Trop. Med. 1:514, 1952. 18. Ash, J. E., and Spitz, S.: Pathology of Tropical Diseases , Philadelphia, W. B. Saunders Company, 1945, p. 325. 19. Allen, A. C.: Persistent "Insect Bites" (Dermal Eosinophilic Granulomas) Simulating Lymphoblastomas, Histiocytes, and Squamous Cell Carcinoma , Am. J. Path. 24:367, 1948. 20. Winer, L. H., and Strakosch, E. A.: Tick Bites—Dermacentor variabilis (Say) , J. Invest. Dermat. 4:249, 1941. 21. Sulzberger, M. B., and Baer, R. L.: Editorial Comment, in Year Book of Dermatology and Syphilology , Chicago, Year Book Publishers, Inc., 1949, p. 44. 22. Bateman, T.: A Practical Synopsis of Cutaneous Diseases : Second American Edition, Philadelphia, James Crissy, 1824. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

HISTOPATHOLOGIC CORRELATION OF LESIONS OF PAPULAR URTICARIA AND POSITIVE SKIN TEST REACTIONS TO INSECT ANTIGENS

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1954.01540220039005
Publisher site
See Article on Publisher Site

Abstract

Abstract A SUBSTANTIAL body of evidence indicates that many cases of papular urticaria are related to insect bite sensitivity.* This opinion is based, in part, on the fact that the patients with papular urticaria give positive delayed (tuberculin type) skin test reactions to the intradermal injection of insect antigen. (Figs. 1, 2, and 3). In an effort to determine the validity of this etiologic concept, we have examined a number of lesions of papular urticaria histologically and have compared these findings with those of positive urticarial and delayed tuberculin-type skin reactions to insect antigen, and with ordinary insect bites. These studies have shown a striking similarity of such lesions. METHOD OF STUDY Patients with papular urticaria were given intracutaneous injections of mosquito (Culex pipiens) flea, (Ctenocephalides felis), and bedbug (Cimex lectularius) antigens. These antigens were prepared after the method of Cherney and co-workers14; 0.1 cc. of 1: 5,000 References 1. References 1 to 13. 2. References 1 and 2. 3. Shaffer, B.; Spencer, M. C., and Blank, H.: Papular Urticaria; Its Response to Treatment with DDT and the Role of Insect Bites in Its Etiology , J. Invest. Dermat. 2:293, 1948.Crossref 4. Blank, H.; Shaffer, B.; Spencer, M. C., and March, W. C.: Papular Urticaria; Study of the Role of Insect in Its Etiology and the Use of DDT in Its Treatment , Pediatrics 5:408, 1950. 5. Shaffer, B.; Jacobson, C., and Beerman, H.: Papular Urticaria, Its Relationship to Insect Allergy , Ann. Allergy 10:411, 1952. 6. Chipman, E. D.: Urticaria, with Special Reference to the Cause in Papular Forms of Children , California Med. 8:207, 1910. 7. Dietrich, A.: Hautreaktionen nach Ungezieferbissen , Monatsschr. Kinderh. 75:70, 1938. 8. Dietrich, A.: Hautreaktionen nach Ungezieferstichen unter dem Bild eines Lichen urticatus , Arch. Dermat. u. Syph. 182:668, 1942.Crossref 9. Hamburger, F.: Lichen urticatus durch Ungeziefer: Reply to Pfaundler , München. med. Wchnschr. 89:652, 1942. 10. Lunsford, C. J.: Flea Problem in California , Arch. Dermat. & Syph. 60:1184, 1949. 11. Goldman, L.: Lichen Urticatus Syndrome as a Manifestation of Sensitivity to Bites from Various Species of Anthropods , Arch. Dermat. & Syph. , 58:74, 1948. 12. Bowen, R.: Insects and Allergic Problems , South. M. J. 44:838, 1951. 13. Fuchs, H.: Urticaria papulosa durch Stiche von Scleroderma domestica , Dermatologica 105:213, 1952. 14. Harant, H., and Huttel, W.: Un insecte vulnérant peu connu , Bull. Soc. path. exot. 43:449, 1950. 15. Rook, A., and Frain-Bell, W.: Papular Urticaria , Arch. Dis. Childhood 28:304, 1953. 16. Cherney, L. S.; Wheeler, C. M., and Reed, A. C.: Flea Antigen in Prevention of Flea Bites , Am. J. Trop. Med. 19:327, 1939. 17. Goldman, L.; Rockwell, E., and Richfield, D. F.: III. Histopathological Studies on Cutaneous Reactions to Bites of Various Arthropods , Am. J. Trop. Med. 1:514, 1952. 18. Ash, J. E., and Spitz, S.: Pathology of Tropical Diseases , Philadelphia, W. B. Saunders Company, 1945, p. 325. 19. Allen, A. C.: Persistent "Insect Bites" (Dermal Eosinophilic Granulomas) Simulating Lymphoblastomas, Histiocytes, and Squamous Cell Carcinoma , Am. J. Path. 24:367, 1948. 20. Winer, L. H., and Strakosch, E. A.: Tick Bites—Dermacentor variabilis (Say) , J. Invest. Dermat. 4:249, 1941. 21. Sulzberger, M. B., and Baer, R. L.: Editorial Comment, in Year Book of Dermatology and Syphilology , Chicago, Year Book Publishers, Inc., 1949, p. 44. 22. Bateman, T.: A Practical Synopsis of Cutaneous Diseases : Second American Edition, Philadelphia, James Crissy, 1824.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Oct 1, 1954

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