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CHOLESTEROL FRACTIONATION STUDIES OF THE SERUM OF XANTHELASMA PATIENTS

CHOLESTEROL FRACTIONATION STUDIES OF THE SERUM OF XANTHELASMA PATIENTS Abstract THE ASSOCIATION of hypercholesteremia with xanthelasma has been the subject of study by a number of investigators. Although a fair percentage of these cases show definite hyperlipemia and hypercholesteremia, others show values that are well within the accepted normal range. Thus the significance of the concentration of plasma lipids as an etiological factor in the development of these lesions still remains in doubt and additional studies on the subject are needed. In 1948 Forbes and associates1 showed that only a small part of the total cholesterol of lyophilized normal plasma or serum is extracted by cold chloroform, while most of the cholesterol of lyophilized serum from nephrotic patients and hypercholesteremic rabbits was thus extracted. This fraction which is thus extracted has been designated the "readily extractable" cholesterol. These investigators expressed the belief that the readily extractable fraction probably represents cholesterol which is either not bound or, at References 1. Forbes, J. C.; Dillard, G. H. L.; Porter, W. B., and Petterson, O.: Fractionation of Serum Cholesterol , Proc. Soc. Exper. Biol. & Med. 68:240, 1948. 2. Gofman, J. W.; Lindgren, F.; Elliott, H.; Mantz, W.; Hewit, J.; Strisower, B.; Herring, V., and Lyon, T. P.: Role of Lipids and Lipoproteins in Atherosclerosis , Science 111:166, 1950. 3. Gershberg, H., and Forbes, J. C.: Determination of Cholesterol in Whole Blood, Serum or Plasma , J. Lab. & Clin. Med. 27:1439, 1942. 4. Forbes, J. C., and Irving, H.: Determination of Cholesterol in Whole Blood , J. Lab. & Clin. Med. 16:909, 1931. 5. Bloor, W. R.: Determination of Small Amounts of Lipid in Blood Plasma , J. Biol. Chem. 77:53, 1928. 6. King, E. J.: Colorimetric Determination of Phosphorus , Biochem. J. 26: 292, 1932. 7. Forbes, J. C., and Outhouse, E. L.: Micromethod for Determination of Tissue Lipids , J. Lab. & Clin. Med. 25:1157, 1940. 8. Thannhauser, S. J.: Lipidoses , in Christian, H. A.: Oxford Loose-Leaf Medicine , ed. 2, New York, Oxford University Press, 1949, vol. 4, pt. (1) , p. 214 (55). 9. Becker, G. H.; Meyer, J., and Necheles, H.: Fat Absorption and Atherosclerosis , Science 110:529, 1949. 10. Supplied by Dr. David Klein, Wilson Laboratories, in the form of 5 grain (0.30 Gm.) enteric-coated, concentrated pancreatin tablets. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

CHOLESTEROL FRACTIONATION STUDIES OF THE SERUM OF XANTHELASMA PATIENTS

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1950 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1950.01530180070013
Publisher site
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Abstract

Abstract THE ASSOCIATION of hypercholesteremia with xanthelasma has been the subject of study by a number of investigators. Although a fair percentage of these cases show definite hyperlipemia and hypercholesteremia, others show values that are well within the accepted normal range. Thus the significance of the concentration of plasma lipids as an etiological factor in the development of these lesions still remains in doubt and additional studies on the subject are needed. In 1948 Forbes and associates1 showed that only a small part of the total cholesterol of lyophilized normal plasma or serum is extracted by cold chloroform, while most of the cholesterol of lyophilized serum from nephrotic patients and hypercholesteremic rabbits was thus extracted. This fraction which is thus extracted has been designated the "readily extractable" cholesterol. These investigators expressed the belief that the readily extractable fraction probably represents cholesterol which is either not bound or, at References 1. Forbes, J. C.; Dillard, G. H. L.; Porter, W. B., and Petterson, O.: Fractionation of Serum Cholesterol , Proc. Soc. Exper. Biol. & Med. 68:240, 1948. 2. Gofman, J. W.; Lindgren, F.; Elliott, H.; Mantz, W.; Hewit, J.; Strisower, B.; Herring, V., and Lyon, T. P.: Role of Lipids and Lipoproteins in Atherosclerosis , Science 111:166, 1950. 3. Gershberg, H., and Forbes, J. C.: Determination of Cholesterol in Whole Blood, Serum or Plasma , J. Lab. & Clin. Med. 27:1439, 1942. 4. Forbes, J. C., and Irving, H.: Determination of Cholesterol in Whole Blood , J. Lab. & Clin. Med. 16:909, 1931. 5. Bloor, W. R.: Determination of Small Amounts of Lipid in Blood Plasma , J. Biol. Chem. 77:53, 1928. 6. King, E. J.: Colorimetric Determination of Phosphorus , Biochem. J. 26: 292, 1932. 7. Forbes, J. C., and Outhouse, E. L.: Micromethod for Determination of Tissue Lipids , J. Lab. & Clin. Med. 25:1157, 1940. 8. Thannhauser, S. J.: Lipidoses , in Christian, H. A.: Oxford Loose-Leaf Medicine , ed. 2, New York, Oxford University Press, 1949, vol. 4, pt. (1) , p. 214 (55). 9. Becker, G. H.; Meyer, J., and Necheles, H.: Fat Absorption and Atherosclerosis , Science 110:529, 1949. 10. Supplied by Dr. David Klein, Wilson Laboratories, in the form of 5 grain (0.30 Gm.) enteric-coated, concentrated pancreatin tablets.

Journal

A.M.A. Archives of Dermatology & Syphilology – American Medical Association

Published: Nov 1, 1950

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